Determination of Tetramine in Postmortem Specimens by GC-NPD

Abstract

A method for the determination of tetramine in postmortem specimens is reported. Tetramine is an organosulfur rodenticide. Parathion, an organophosphorous insecticide, was adopted as the internal standard. Both were extracted from biological materials by benzene and purified by an aluminum oxide column. The extract was analyzed by a gas chromatograph equipped with a nitrogen-phosphorous detector. The extraction efficiency was greater than 90%, and the limit of detection was 0.05 microgram/g for the liver. The standard curve was linear in the range 0.5-50 micrograms/g for the liver, and the correlation coefficient was equal to 0.9993.

Tetramethylenedisulfotetramine: Old Agent and New Terror

“…The compound has been identified in blood by several methods, including gas chromatography with nitrogen-phosphorous detection, gas chromatography with flame photometric detection, and gas chromatography mass spectrophotometer. 11,22,23 Because of the difficulty of obtaining an analytic standard in the New York City poisoning, as previously described, the laboratory synthesized a tetramethylenedisulfotetramine standard with a purity of at least 95% with the method described in Barrueto et al 3 …”

Profiling of volatile impurities in tetramethylenedisulfotetramine (TETS) for synthetic-route determination

“…In most cases, exposure to TETS was through the ingestion of intentionally contaminated foods. Given this obvious public threat, researchers have developed methods for its analysis in biological and food matrices [8][9][10][11][12][13][14]. These methods have focused on the detection of TETS at trace levels.…”

Determination of tetramethylenedisulfotetramine in human urine with gas chromatograph-flame thermionic detection coupling with direct immersed solid-phase micro-extraction

“…For the analyses of tetramine in human blood, urine, stomach tissue and contaminated feed, a number of methods such as gas chromatography (GC), gas chromatographymass spectrometry (GC/MS), nuclear magnetic resonance (NMR) and capillary electrophoresis-mass spectrum (CE/ MS) have been reported [2][3][4][5][6][7][8][9][10]. Among these methods, GC is one of the most widely used technique for the determination of its residue.…”