Determination of tetrabromobisphenol A in human serum by liquid chromatography–electrospray ionization tandem mass spectrometry

Hayama, Tadashi; Yoshida, Hideyuki; Onimaru, Suzuko; Yonekura, Sayuri; Kuroki, Hiroaki; Todoroki, Kenichiro; Nohta, Hitoshi; Yamaguchi, Masatoshi

doi:10.1016/j.jchromb.2004.06.013

Cited by 57 publications

(23 citation statements)

References 16 publications

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“…Hayama et al 2004), human adipose tissue ( Johnson-Restrepo et al 2008) and umbilical cord serum (Antignac et al 2008). Evaluation of BFRs in archived human serum samples in Norway showed a temporal increase in concentrations of six PBDE congeners and TBBPA over the period 1977 -1999.…”

Section: (C) Conclusionmentioning

confidence: 99%

Components of plastic: experimental studies in animals and relevance for human health

Talsness

Andrade

Kuriyama

et al. 2009

Phil. Trans. R. Soc. B

527

257

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Components used in plastics, such as phthalates, bisphenol A (BPA), polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A (TBBPA), are detected in humans. In addition to their utility in plastics, an inadvertent characteristic of these chemicals is the ability to alter the endocrine system. Phthalates function as anti-androgens while the main action attributed to BPA is oestrogen-like activity. PBDE and TBBPA have been shown to disrupt thyroid hormone homeostasis while PBDEs also exhibit anti-androgen action. Experimental investigations in animals indicate a wide variety of effects associated with exposure to these compounds, causing concern regarding potential risk to human health. For example, the spectrum of effects following perinatal exposure of male rats to phthalates has remarkable similarities to the testicular dysgenesis syndrome in humans. Concentrations of BPA in the foetal mouse within the range of unconjugated BPA levels observed in human foetal blood have produced effects in animal experiments. Finally, thyroid hormones are essential for normal neurological development and reproductive function. Human body burdens of these chemicals are detected with high prevalence, and concentrations in young children, a group particularly sensitive to exogenous insults, are typically higher, indicating the need to decrease exposure to these compounds.

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Section: (C) Conclusionmentioning

confidence: 99%

Components of plastic: experimental studies in animals and relevance for human health

Talsness

Andrade

Kuriyama

et al. 2009

Phil. Trans. R. Soc. B

527

257

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show abstract

“…Its consumption is expected to grow continuously as electronic products become more popular than ever before and the life cycles of these electronic devices become shorter. Because of its widespread use, high lipophilicity, and environmental persistency, TBBPA has been detected in various environmental matrices, such as sewage sludge (Oberg et al, 2002;Morris et al, 2004), sediments (Luo et al, 2010b), air (Sjodin et al, 2001;Inoue et al, 2006) and human blood (Thomsen et al, 2001;Jakobsson et al, 2002;Hayama et al, 2004). For instance, Morris et al (2004) reported a level of 100 lg kg À1 of TBBPA in sewage sludge from North Sea Estuaries; Luo et al (2010b) found 3.8-255 ng g À1 of the pollutant in freshwater sediments from Dongjiang River; Sjodin et al (2001) Safe disposal and recycling of electrical wastes (e-wastes) and other BFR containing wastes become urgent as the amount of TBBPA-containing e-wastes increases rapidly in recent years.…”

Section: Introductionmentioning

confidence: 99%

Reductive debromination of tetrabromobisphenol A by Pd/Fe bimetallic catalysts

Huang

Peng

et al. 2013

Chemosphere

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“…One of the main limitations of these LLE-based procedures is the long waiting time or centrifugation required for phase separation. Alternatively, an SPE-based method using Abselut Nexus sorbents have been proposed for the determination of TBBPA in serum [21]. After serum or milk denaturation with formic acid and isopropanol, Thomsen et al [22,23] have employed SPE on OASIS HLB cartridges to extract HBCD from human serum or milk.…”

Section: Biological Tissuesmentioning

confidence: 99%

“…Both the derivatization and acidification step can introduce errors and/or losses [4]. In terms of sensitivity, LC-ESI-MS-MS can be competitive with published GC-EI-MS-MS techniques, with LODs in the ppt-range [21]. A GC-HRMS method requiring derivatization with methyl-chloroformate was developed by Berger et al [34].…”

Section: Tbbpamentioning

confidence: 99%

Recent Methodologies for Brominated Flame Retardant Determinations by Means of Liquid Chromatography–Mass Spectrometry

Guerra

Eljarrat

Barceló

2010

Brominated Flame Retardants

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In this chapter, an overview of current analytical methods, including different sample preparation techniques as well as the different instrumental approaches, is presented. The strategy literature search for the preparation of this chapter was based on the recent analytical reviews published on brominated flame retardants (BFRs), with emphasis on hexabromocyclododecane (HBCD) and tetrabromobisphenol-A (TBBPA). Additionally, we have included all new articles published in peer-reviewed scientific journals, conference proceedings, or official reports found on the internet. The analytical procedures based on the use of liquid chromatography, used for the determination of some BFRs such as TBBPA, HBCD, as well as some metabolites and transformation products are presented. Analytical performances of the different approaches (ESI, APCI, and APPI as ionization modes) are reported and compared with those obtained by gas chromatographic techniques. Conclusions and future perspectives are outlined.

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Determination of tetrabromobisphenol A in human serum by liquid chromatography–electrospray ionization tandem mass spectrometry

Cited by 57 publications

References 16 publications

Components of plastic: experimental studies in animals and relevance for human health

Components of plastic: experimental studies in animals and relevance for human health

Reductive debromination of tetrabromobisphenol A by Pd/Fe bimetallic catalysts

Recent Methodologies for Brominated Flame Retardant Determinations by Means of Liquid Chromatography–Mass Spectrometry

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