Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

“…Anti-solvent methods have been used extensively in the synthesis of sub-micron and micron size particles of insoluble drug moieties [6,7]. The formation, stabilization and sedimentation of these particles depend upon the discreet steps of nucleation, condensation and coagulation into larger particles [8][9][10].…”

Simultaneous synthesis, stabilization, and self‐assembly of microscale drug particles in polymer films

“…Antisolvent methods have been used in the synthesis of submicrometer and micrometer size particles of insoluble drug moieties 18, 19. Nucleation and condensation tend to be competing factors as both consume solute molecules, whereas the coagulation step involves aggregation 20–22.…”

Aerosol based detectors for the investigation of phospholipid hydrolysis in a pharmaceutical suspension formulation

“…Hence, a quadratic relationship was fitted with R 2 values ranging from 0.98 to 0.99 (data not shown). An alternate approach to solve the problems of laborious standards preparation and data processing that are typically associated with the quadratic calibration plots is the use of log-log plots [24,25]. Calibration curves were constructed by plotting logarithm of analyte concentrations against the logarithm of peak areas.…”