Determination of sulphachloropyrazine-diaveridine residues by high performance liquid chromatography in broiler edible tissues

Li, Yongjun; Shi-jin, BU

doi:10.1292/jvms.14-0605

Cited by 8 publications

(6 citation statements)

References 24 publications

(27 reference statements)

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“…In the case of edible tissues, Łebkowska-Wieruszewska and Kowalski [ 16 ], as weel as Li and Bu [ 17 ], found that sulfachloropyridazine reached high concentrations up to day 4 after ceasing treatment, approximately; afterward, its concentrations quickly declined below the LOD. Furthermore, Łebkowska-Wieruszewska and Kowalski [ 18 ] had previously detected this drug in muscle and liver samples of turkeys, where its concentrations diminished rapidly seven days after ceasing treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, several studies have analyzed the pharmacological behavior of antimicrobials belonging to the family of sulfonamides, on different edible tissues of poultry. For example, Łebkowska-Wieruszewska and Kowalski [ 16 ], as well as Li and Bu [ 17 ], determined sulfachloropyrazine in muscle, liver, skin and fat of broiler chickens, after receiving medicated feed. These authors concluded that this drug reached high concentrations up to day 4 after ceasing treatment, before it quickly declined to levels below the limit of detection for the analytical methodology.…”

Section: Introductionmentioning

confidence: 99%

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Determination of sulfachloropyridazine residue levels in feathers from broiler chickens after oral administration using liquid chromatography coupled to tandem mass spectrometry

et al. 2018

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Several antimicrobials are routinely used by the poultry farming industry on their daily operations, however, researchers have found for some antimicrobials that their residues persist for longer periods in feathers than they do in edible tissues, and at higher concentrations, as well. But this information is not known for other classes of antimicrobials, such as the sulfonamides. Therefore, this work presents an accurate and reliable analytical method for the detection of sulfachloropyridazine (SCP) in feathers and edible tissues from broiler chickens. This method was also validated in-house and then used to study the depletion of sulfachloropyridazine in those matrices. The experimental group comprised 54 broiler chickens, who were raised under controlled conditions and then treated with a commercial formulation of 10% sulfachloropyridazine for 5 days. Samples were analyzed via LC-MS/MS, using 13C6-sulfamethazine (SMZ-13C6) as an internal standard. Aromatic sulfonic acid solid phase extraction (SPE) cartridges were used to clean up the samples. The Limit of Detection (LOD) for this method was set at 10 μg kg-1 on feathers and liver; and at 5 μg kg-1 on muscle. Within the range of 10–100 μg kg-1, the calibration curves for all matrices presented a determination coefficient greater than 0.96. Our results show, with a 95% confidence level, that sulfachloropyridazine persisted in feathers for up to 55 days after ceasing treatment, and its concentrations were higher than in edible tissues. In consequence, to avoid re-entry of antimicrobial residues into the food-chain, we recommend monitoring and inspecting animal diets that contain feather derivatives, such as feathers meals, because they could be sourced from birds that might have been medicated with sulfachloropyridazine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of sulfachloropyridazine residue levels in feathers from broiler chickens after oral administration using liquid chromatography coupled to tandem mass spectrometry

et al. 2018

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“…The slow elimination of DVD in chicken plasma indicates a longer residue in tissues and organs. Li and Bu ( 3 ) confirmed that withdrawal period of DVD in muscle, liver, kidney and skin with fat were 4.77, 4.94, 6.74. and 4.58 d, respectively ( 3 ). Compared with muscle and skin with fat, the kidney has a longer elimination half-life of DVD, followed by the liver.…”

Section: Discussionmentioning

confidence: 87%

“…When combined with sulfonamides or other antimicrobial agents, DVD blocks the metabolism of folic acid in bacteria by two different mechanisms thereby leading to antibacterial synergistic effects that result in a reduction in resistant strain generation ( 2 ). DVD exhibits in vitro antibacterial efficacy against most Gram-negative and Gram-positive bacteria, including Escherichia coli, Clostridium spp., Salmonella spp., Staphylococcus aureus , and Bacillus anthracis ( 3 , 4 ). It is also noteworthy that DVD has remarkable activity against coccidia and other protozoa.…”

Section: Introductionmentioning

confidence: 99%

Metabolite Identification and Pharmacokinetic Behavior of Diaveridine in the Plasma of Pigs and Chickens Based on Radioactive Tracing Coupled With LC/MS-IT-TOF Assay

et al. 2022

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Diaveridine (DVD) is widely used for the prevention and treatment of coccidiosis and leucocytozoonosis infections in food-producing animals. To gain a better understanding of DVD metabolism and pharmacokinetics in healthy Landrace/Doric Cross castrated male pigs and both female and male Cobb 500 broiler chickens, a method involving radioactive tracing coupled with LC/MS-IT-TOF was developed for the identification and quantitation of DVD and its metabolites in pig and chicken plasma, and then was applied to investigate DVD pharmacokinetics. A simple MCX solid phase extraction procedure was adopted for sample preparation. After a single oral administration of 3H-DVD (10 mg/kg BW), three radioactive compounds (D0: DVD; D1: 3′-desmethyl-DVD; and D2: monoglucuronide of 3′-desmethyl-DVD) were identified in pig plasma, while only two radioactive compounds (D0 and D2) were identified in chicken plasma. In both species, the Cmax values for all detected compounds were reached at 2 h after dosing. The Cmax order was D2 (1.38 μg/ml) > D0 (0.49 μg/ml) > D1 (0.24 μg/ml) in pigs and D0 (1.55 μg/ml) > D2 (0.27 μg/ml) in chickens. The longer t1/2 (elimination half-life) of D0 contributed to the slow elimination of DVD-related compounds. The t1/2β of D0 in pigs (66.41 h) was significantly longer than that in chickens (48.30 h), but the t1/2 of total DVD-related metabolites in pigs (42.86 h) was lower than that in chickens (56.11 h). These findings suggested that the metabolism and pharmacokinetics of DVD in pigs and chickens were significantly different, and that this would affect its effectiveness, toxicology, and food safety in these animals.

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“…Our research showed that the DVD-related residues in the kidneys were eliminated more slowly than those in the liver and other tissues/organs. This result was also verified by a residue depletion study of DVD . Therefore, in both swine and chickens, the kidneys should be designated the target tissue for monitoring DVD residue.…”

Section: Discussionmentioning

confidence: 99%

Metabolism and Tissue Elimination of Diaveridine in Swine, Chickens, and Rats Using Radioactive Tracing Coupled with LC–ESI–IT–TOF/MS

Wang

Wen

Pan

et al. 2023

J. Agric. Food Chem.

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Diaveridine (DVD) has widespread use in food animals due to its antibacterial synergistic effects. This study revealed the metabolism, excretion, and tissue elimination of DVD in swine, chickens, and rats following oral gavage of 10 mg/kg b.w. tritium-labeled DVD using radioactive tracing coupled with liquid chromatography–electron spray ionization–ion trap–time-of-flight–mass spectrometry (LC–ESI–IT–TOF/MS). The metabolic pathways involved demethylation, α-hydroxylation, glucuronidation, and sulfonylation and produced four metabolites in swine (M0, DVD; M1, 3’/4′-demethyl-DVD; M2, 3’/4′-demethyl-DVD-O-glucuronide; M4, 2/4-glucuronidated-DVD) and five in chickens (M0∼M2; M3, α-hydroxy-DVD; M4) and rats (M0∼M3; M5, 3’/4′-demethyl-DVD-O-sulfation). M0 was dominant in the excreta of chicken and female and male rats, while M2 was mainly excreted in swine. Among the three species studied, M0 was the most persistent in the kidneys (t 1/2 3.15–3.89 d); therefore, M0 kidney levels are residue monitoring targets. This study enabled a thorough comprehension of the metabolism and pharmacokinetic characteristics of DVD in animals.

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Determination of sulphachloropyrazine-diaveridine residues by high performance liquid chromatography in broiler edible tissues

Cited by 8 publications

References 24 publications

Determination of sulfachloropyridazine residue levels in feathers from broiler chickens after oral administration using liquid chromatography coupled to tandem mass spectrometry

Determination of sulfachloropyridazine residue levels in feathers from broiler chickens after oral administration using liquid chromatography coupled to tandem mass spectrometry

Metabolite Identification and Pharmacokinetic Behavior of Diaveridine in the Plasma of Pigs and Chickens Based on Radioactive Tracing Coupled With LC/MS-IT-TOF Assay

Metabolism and Tissue Elimination of Diaveridine in Swine, Chickens, and Rats Using Radioactive Tracing Coupled with LC–ESI–IT–TOF/MS

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