Determination of sulfonamides in milk and egg samples by HPLC with mesoporous polymelamine‐formaldehyde as magnetic solid‐phase extraction adsorbent

Abstract

In this work, magnetic mesoporous polymelamine-formaldehyde composites were synthesized via a facile Schiff base reaction. The magnetic mesoporous polymelamine-formaldehyde composites combined both the properties of mesoporous polymelamine-formaldehyde and the magnetism of NH 2 -SiO 2 @Fe 3 O 4 nanoparticles, possessing high specific surface area (150.66 m 2 g -1 ) and good magnetism (24.50 emu g -1 ). The magnetic mesoporous polymelamineformaldehyde composites were employed as magnetic adsorbent for the extraction of sulfonamides. Under optimal conditions, good linearities with correlation coefficients higher than 0.9984 were obtained between peak area and sulfonamides concentration (2-200 μg L -1 ) with limits of detection in the range of 0.33-0.58 μg L -1 . The established method was successfully applied for the determination of sulfonamides in egg and milk samples. The adsorption mechanisms demonstrated that the adsorption of magnetic mesoporous polymelamine-formaldehyde composites toward sulfonamides was a multilayer process, and adsorption kinetics followed the pseudo-second-order model.

Trends of Novel Functional Nanomaterials for Analysis of Sulfonamide Residues in Food Products

“…The method has a wide linear range (up to 250 μg L −1 ), confirming the affinity of zinc for SAs, and can be used to determine SAs with concentrations higher or lower than the MRL [23]. Magnetic mesoporous polymelamine formaldehyde composites, which exhibited the combined properties of NH 2 -SiO 2 @Fe 3 O 4 and magnetic properties of nanoparticles, were successfully applied to determine SAs in eggs and milk samples [24]. Magnetic dispersion SPE combined with ion pair DLLME (MDSPEi-DLLME) was employed to detect SAs in animal food with detection limits of 0.01 to 5 μg kg −1 and linear range of 0.1-400 μg kg −1 [25].…”

Detecção Simultânea por HPLC/UV de Sulfonamidas em Leite Utilizando Extração por Sorção em Fase de Tecido

“…According to a literature review, numerous studies analyzing sulfonamides in milk by HPLC (Armentano et al, 2018;Duan et al, 2020;Feng et al, 2019;Karageorgou et al, 2016;Kechagia et al, 2017;Li et al, 2015;Liao et al, 2021;Maggira et al, 2019;Manzanares et al, 2014;Nebot et al, 2013;Qi et al, 2018;Tolika et al, 2011;Wang et al, 2016;Wu et al, 2007;Zhang et al, 2019) utilize various compositions and distinct proportions of ACN, MeOH, and an acidic solution or buffer, including acetic or formic acid, as the mobile phase.…”

Rapid and Sensitive Detection of Sulfamethizole Using a Reusable Molecularly Imprinted Electrochemical Sensor

“…At present, various analytical methods have been reported for detecting SAs, including high-performance liquid chromatography (HPLC) [ 4 ], ultra-high-performance liquid chromatography–mass spectrometry (UPLC–MS) [ 5 ], liquid chromatography–mass spectrometry (LC–MS) [ 6 ], capillary electrophoresis [ 7 ], immunoassays [ 8 ], surface-enhanced Raman spectroscopy (SERS) [ 9 ], and using electrochemical sensors [ 10 , 11 ]. Among them, electrochemical methods offer the benefits of elevated sensitivity, accuracy, convenient operation, cheap instrumentation, facile integration, and portability [ 12 ].…”