Determination of small carboxylic acids by ion exclusion chromatography with electrospray mass spectrometry

Johnson, Steve K.; Houk, Linda L.; Feng, Jianren; Johnson, Dennis C.; Houk, R. S.

doi:10.1016/s0003-2670(96)00572-7

Cited by 40 publications

(13 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the IEC/ES‐MS method of Houk9 aqueous TFA was used as the mobile phase and pH adjustment of the TFA eluent was performed by post‐column addition of propanol and ammonium hydroxide to convert the carboxylic acids into anions and improve the anion signal for electrospray. Not only is this a complicated system, but the detection limits for each carboxylic acids were not always higher than our results.…”

Section: Resultsmentioning

confidence: 99%

“…Detection limits of 10 ppm were obtained for glycolic, acetic, propionic and butyric acids. In 1997, Houk assessed the separation of a mixture of formic, glyoxylic, oxalic, 2‐hydroxyisobutyric and maleic acids, with detection limits of 2–8 ppm being obtained for ion exclusion chromatography with ESI‐MS 9. On the other hand, a recent study by Helaleh10 focused on the determination of hydrochloric, formic, acetic, propionic, isobutyric, isovaleric, valeric and isocaproic acids by ion exclusion chromatography/atmospheric pressure chemical ionization (APCI) with little sample preparation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Improved liquid chromatography/mass spectrometric analysis of low molecular weight carboxylic acids by ion exclusion separation with electrospray ionization

Gamoh¹,

Saitoh²,

Wada³

2003

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

An improved, simple and sensitive analytical method for low molecular weight organic acids has been developed. A mixture of acetic, propionic, butyric, glycolic, lactic, 2-hydroxybutyric, malonic, succinic, glutaric, tartaric and citric acids was separated on a semi-rigid styrene-divinylbenzene copolymer-based H-type cation-exchange resin (ULTRON PS-80H) based on an ion exclusion chromatographic (IEC) mechanism, with detection using electrospray ionization mass spectrometry (ESI-MS). Formic or acetic acid was used as a mobile phase to separate the carboxylic acids within 15 min. For liquid chromatography/mass spectrometry (LC/MS), the ESI interface was used in both positive and negative ionization mode. ESI produced reasonable signals from positive ions, [M+NH(4)](+), of acetic, propionic and butyric acids and from negative ions, [M-H](-), of glycolic, lactic, 2-hydroxybutyric, malonic, succinic, glutaric, tartaric and citric acids. The effects of ionization parameters, source temperature, capillary voltage and cone voltage, on sensitivity and linearity were examined. Linear plots of peak area versus concentration were obtained over the range 0.1-20 ppm for MS detection. The detection limits of the target carboxylic acids calculated at signal-to-noise (S/N) ratio of 3 ranged from 9 to 59 ppb. The reproducibility of retention times and peak areas were 0.55-1.25 and 0.85-2.45%, respectively.

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Improved liquid chromatography/mass spectrometric analysis of low molecular weight carboxylic acids by ion exclusion separation with electrospray ionization

Gamoh¹,

Saitoh²,

Wada³

2003

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

“…This side-effect is probably one of the main analytical problems of LC-MS related techniques that may have critical consequences for the analytical results (Johnson, Houk, Feng, Johnson, & Houk, 1997;Van Eeckhaut, Lanckmans, Sarre, Smolders, & Michotte, 2009). To evaluate the matrix effect, the response of the organic acid in solution was compared with the response of these compounds in the fruit material.…”

Section: Performance Of the Lc-esi-ms Methodsmentioning

confidence: 99%

Development of a rapid and direct method for the determination of organic acids in peach fruit using LC–ESI-MS

et al. 2016

View full text Add to dashboard Cite

“…Currently, the main classes of organic compounds targeted by single quadrupole IC/MS are low molecular weight organic acids,1–5 carbohydrates,6, 7 and synthetic chelating agents 8–10. Important inorganic analytes are oxyhalogenides, e.g.…”

mentioning

confidence: 99%

CC Bond Cleavage of Zwitterionic Carboranes Promoted by a Half‐Sandwich Iridium(III) Complex

Yao

Lin

et al. 2013

Chemistry A European J

View full text Add to dashboard Cite

show abstract

Determination of small carboxylic acids by ion exclusion chromatography with electrospray mass spectrometry

Cited by 40 publications

References 22 publications

Improved liquid chromatography/mass spectrometric analysis of low molecular weight carboxylic acids by ion exclusion separation with electrospray ionization

Improved liquid chromatography/mass spectrometric analysis of low molecular weight carboxylic acids by ion exclusion separation with electrospray ionization

Development of a rapid and direct method for the determination of organic acids in peach fruit using LC–ESI-MS

CC Bond Cleavage of Zwitterionic Carboranes Promoted by a Half‐Sandwich Iridium(III) Complex

Contact Info

Product

Resources

About