Determination of small carboxylic acids by capillary electrophoresis with electrospray-mass spectrometry

Johnson, Steve K.; Houk, Linda L.; Johnson, Dennis C.; Houk, R. S.

doi:10.1016/s0003-2670(99)00122-1

Cited by 47 publications

(35 citation statements)

References 41 publications

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“…Ion trap Sheath liquid a) FASS, field-amplified sample stacking in the presence of siphoning [326] Basic dendrimers CZE Magnetic sector Sheath liquid [327] Low-molecular-mass compounds CZE Single quadrupole Sheath liquid [328] Small carboxylic acids CZE Single quadrupole Sheath liquid [329] a-and b-chains of hemoglobin of a single intact red blood cell CZE TOF In-column electrode [330] Trace impurities of peptides and alkaloids CZE Triple quadrupole Make-up flow [331] Amino acids CZE Single quadrupole Sheath liquid…”

Section: ] Capillary Isotachophoresis Esi-ms (Citp-esi-ms) A)mentioning

confidence: 99%

Capillary electrophoresis – mass spectrometry: 15 years of developments and applications

Schmitt‐Kopplin¹,

Frommberger²

2003

Electrophoresis

282

232

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Capillary electrophoresis -mass spectrometry: 15 years of developments and applicationsSince its introduction in 1987, capillary electrophoresis-mass spectrometry (CE-MS) has developed to a well accepted multidimensional analytical approach complementary and/or competitive to classical MS-hyphenated separation techniques. The threefold combination of rapid developments of an exceptional separation technique, of selective mass detection possibilities, and of very mild ionization modes first allowed these progresses. This article shows the CE specificities that need to be well controlled/known, compared to classical and more routinely used liquid chromatography in the light of its coupling to MS. The major trends and developments over the last 15 years and most of the reviews and applications found in ISI Web of science and publisher databases are presented in a tabulated way. The reader can thus rapidly find existing CE-MS analysis techniques in his field of research and application (forensics, environment, bioanalytics, pharmaceutics, and metabolites).

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Section: ] Capillary Isotachophoresis Esi-ms (Citp-esi-ms) A)mentioning

confidence: 99%

Capillary electrophoresis – mass spectrometry: 15 years of developments and applications

Schmitt‐Kopplin¹,

Frommberger²

2003

Electrophoresis

282

232

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“…Indirect UV is nonselective for inorganic anions, as is direct and indirect conductivity, although these latter methods do offer some selectivity over nonelectroactive components within a sample. Potentiometric detection in CZE has been reviewed by Wang and Fang [228], and has been applied to the selective determination of certain organic and inorganic anions by Macka et al [229] However, it is the recent emergence of CE-MS [230,231] which presents the analyst with a truly selective detector for CZE, although it has so far only found limited application in the area of inorganic anions [232]. Table 1 shows the large range in LODs quoted for inorganic anions using numerous CZE methods (in CZE, LODs are commonly accepted as representing the concentration of analyte resulting in a peak height equal to three times the standard deviation of the baseline noise).…”

Section: Detectionmentioning

confidence: 99%

Quantitative capillary zone electrophoresis of inorganic anions

Paull

King

2003

Electrophoresis

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Despite the availability of commercial capillary electrophoresis systems for over ten years, where quantitative analysis is required, capillary zone electrophoresis (CZE) has often failed to replace ion chromatography as the method of choice for a large number of analytes, not least inorganic anions. To investigate the reasons for this apparent failing, a review is presented of work that has been carried out to-date involving the quantitative application of CZE to the determination of inorganic anions in industrial and environmental samples. This review summarizes work both investigating and improving the quantitative aspects of the CZE of inorganic anions. A complete survey of how CZE has been applied to the determination of inorganic anions in real samples is given, including what, if any, analytical performance parameters were investigated and quoted, and if quality assurance data and validation methods were briefly considered, thoroughly investigated or simply ignored.

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“…Although a better separation technique with capillary electrophoresis (CE) has been attempted (Terabe et al, 1991), the selectivity with UV or fluorescent spectrometry still has its limitations. Mass spectrometry (MS) has been employed successfully with CE in the analysis of phenolic compounds (Lafont et al, 1999), herbicides (Song & Budde, 1996), drugs and their metabolites (Lu et al, 1996), and carboxylic acids (Johnson et al, 1999) with the advantage of high selectivity and sensitivity. It was not until recently that CE-MS was claimed to be effective in the analysis of underivatized amino acids (Soga & Heiger, 2000).…”

mentioning

confidence: 99%

Analysis of Dabsyl-Cl Derivated Amino Acids by High Performance Liquid Chromatography and Tandem Mass Spectrometry

Chen

Shih

Liou

et al. 2003

FSTR

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Determination of small carboxylic acids by capillary electrophoresis with electrospray-mass spectrometry

Cited by 47 publications

References 41 publications

Capillary electrophoresis – mass spectrometry: 15 years of developments and applications

Capillary electrophoresis – mass spectrometry: 15 years of developments and applications

Quantitative capillary zone electrophoresis of inorganic anions

Analysis of Dabsyl-Cl Derivated Amino Acids by High Performance Liquid Chromatography and Tandem Mass Spectrometry

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