Determination of Serum/Plasma Concentrations of Psychotropic Drugs in Therapeutic Drug Monitoring

Miroshnichenko, I. I.; Баймеева, Н. В.; Платова, А. И.

doi:10.37489/2587-7836-2021-1-3-13

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…For example, TDM results may be false positive in vegetarians, patients with eating disorders, pregnant women with gestosis of the first trimester of pregnancy, or representatives of certain ethnic groups with a habitually low intake of animal proteins. In such cases, the level of the free fraction of VPA in plasma is explained by the fact that the clearance of VPA is low (6-20 mL/h/kg) due to its high binding to proteins (87-95%) [4,12].…”

Section: Effect Of Variable Alleles Of Genes Encoding Cytochrome P450...mentioning

confidence: 99%

Ethnic Aspects of Valproic Acid P-Oxidation

Shnayder,

Grechkina,

Trefilova

et al. 2024

Biomedicines

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The safety of the use of psychotropic drugs, widely used in neurological and psychiatric practice, is an urgent problem in personalized medicine. This narrative review demonstrated the variability in allelic frequencies of low-functioning and non-functional single nucleotide variants in genes encoding key isoenzymes of valproic acid β-oxidation in the liver across different ethnic/racial groups. The sensitivity and specificity of pharmacogenetic testing panels for predicting the rate of metabolism of valproic acid by P-oxidation can be increased by prioritizing the inclusion of the most common risk allele characteristic of a particular population (country).

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Section: Effect Of Variable Alleles Of Genes Encoding Cytochrome P450...mentioning

confidence: 99%

Ethnic Aspects of Valproic Acid P-Oxidation

Shnayder,

Grechkina,

Trefilova

et al. 2024

Biomedicines

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Monitoring of the Antipsychotic Therapy Effectiveness

Miroshnichenko

2023

Psychiatry

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Background: there is seminal medicine direction in the diagnosis and therapy of mental disorders, namely personalized medicine. Its concept embodies an individual approach to treatment based on the genotype and phenotype of the patient. Objective: the presented paper deal with the main modern approaches to the individualization of psychopharmacotherapy: genotyping, determination of the level of biomarkers and therapeutic drug monitoring (TDM). Methods: databases of medical and biological publications (MEDLINE, PubMed); clinical observations. Results: examples of genetic tests that allow optimizing the therapy of mental illness are presented. The concept of biomarkers as diagnostic and therapeutic indicators in personalized medicine is considered. Other promising areas of scientific research are briefly described: metabolism, transporters, neurotransmitters (mediators), epigenetics. Population modeling of antibiotic pharmacokinetics also deserves attention. Specific examples of TDM content of antipsychotics are given. Conclusion: the reviewed research directions focused on the introduction of the principles of personalized and translational medicine into routine psychiatric practice.

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Determination of Serum/Plasma Concentrations of Psychotropic Drugs in Therapeutic Drug Monitoring

Cited by 2 publications

References 15 publications

Ethnic Aspects of Valproic Acid P-Oxidation

Ethnic Aspects of Valproic Acid P-Oxidation

Monitoring of the Antipsychotic Therapy Effectiveness

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