Determination of Serum C-Reactive Protein (CRP) in Healthy Beagle Dogs of Various Ages and Pregnant Beagle Dogs

Kuribayashi, Takashi; Shimada, Tokihiro; Matsumoto, Mariko; Kawato, Katsuhito; Honjyo, Toshio; Fukuyama, Masafumi; Yamämoto, Yasushi; Yamamoto, Seigo

doi:10.1538/expanim.52.387

Cited by 61 publications

(63 citation statements)

References 14 publications

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“…The concentrations of CRP in control dogs, which ranged from 0.6 to 8.8 mg/ml, are in general agreement with many studies 11,19,27,29 but disagree with others 24 that reported lower ranges for this protein in healthy dogs. Figure 2 shows the variability chart for CRP and triglycerides in both groups, where the points, range bars (which include maximum, median, and minimum quantiles), and cell means can be observed.…”

supporting

confidence: 81%

Association of canine obesity with reduced serum levels of C-reactive protein

et al. 2008

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Abstract. The prevalence of obesity is increasing in dogs as well as in humans. C-reactive protein (CRP) is an important tool for the detection of inflammation and/or early tissue damage and is linked to obesity in humans. The objective of the present study was to determine if serum CRP levels are altered in obese dogs. Fifteen lean (control group) and 16 overweight (obese group) dogs were examined. Blood samples were collected under fasted conditions for serum determination of CRP, glucose, insulin, cholesterol, triglyceride, and fructosamine. Results indicated that obese dogs were insulin resistant because serum insulin and insulin/ glucose ratios were higher than in lean dogs (P # 0.05). Serum CRP concentrations were lower in obese dogs than in controls (P # 0.001). C-reactive protein was negatively correlated with insulin/glucose ratio (R 5 20.42) and cholesterol (R 5 20.39; P # 0.05). Furthermore, levels of cholesterol, triglycerides, and fructosamine were increased in the obese group compared with the control group. Based on these results, it can be postulated that CRP production is inhibited by obesity and insulin resistance in dogs.

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supporting

confidence: 81%

Association of canine obesity with reduced serum levels of C-reactive protein

et al. 2008

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“…1 Serum CRP concentrations are not influenced by age and sex. 2 Serum CRP has shown potential as a prognosticator for survival in some neoplastic conditions such as lymphoma, ovarian cancer, thymic cell carcinoma, pancreatic cancer, and colorectal cancer. 3 Serum CRP concentration is a novel parameter to monitor response to therapy in various inflammatory conditions and to monitor response to treatment and relapse status in dogs with lymphoma.…”

mentioning

confidence: 99%

Serum C‐Reactive Protein Concentration in Benign and Malignant Canine Spirocercosis

Mukorera¹,

Dvir²,

Merwe³

et al. 2011

Veterinary Internal Medicne

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Background: Spirocerca lupi is a nematode of canids that forms a nodule in the esophagus that can undergo neoplastic transformation. C-reactive protein (CRP) is a major acute phase protein in the dog that has been used for treatment, monitoring, and prognostication in inflammatory and neoplastic disease.Hypothesis/Objectives: The objectives of this study were to determine if serum CRP concentration (1) is increased in canine spirocercosis, (2) can be used to determine neoplastic transformation, and (3) can be used to monitor response to treatment in benign spirocercosis.Animals: Forty-two dogs naturally infected with S. lupi and 21 control dogs. Methods: A retrospective study was performed. The infected cases were divided into benign (n 5 28) or malignant (n 5 14) spirocercosis. CRP was performed on all of the spirocercosis and control cases at presentation. Statistical analysis was done by the one-way analysis of variance and Student's t-test.Results: The mean CRP concentration in the benign cases was 60.4 AE 48.0 mg/L and that of the malignant cases was 76.5 AE 44.8 mg/L; both values were significantly higher (P o .001) than those of the control group where the mean was 13.4 AE 17.9 mg/ L. The mean CRP concentration for the convalescent sera in the benign group was lower than the pretreatment concentrations (P 5 .01).Conclusion and Clinical Importance: CRP cannot be used to differentiate between benign and malignant spirocercosis. There is a decrease in CRP concentration in dogs with benign spirocercosis once treatment has commenced. Serial CRP measurement can be used to monitor response to treatment in benign spirocercosis.

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“…The inflammatory response at implantation was followed by an increase in serum C-reactive protein in the dog (Concannon et al, 1996). Although measurement of acute phase proteins has been suggested as a method of pregnancy diagnosis since pregnancy specific increase in circulating concentrations was observed (Eckersall et al, 1993) yet a reliable test is not available notwithstanding further research in this area (Kuribayashi et al, 2003;Ulutas et al, 2009).…”

Section: Acute Phase Proteinsmentioning

confidence: 99%

Trophoblast of domestic and companion nimals: basic and applied clinical perspectives

Peter¹,

Beg²,

Ahmad³

et al. 2017

Anim Reprod

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The trophoblast is the single most important functional structure of the placenta that mediates the attachment of the blastocyst to the endometrium. Trophoblast has the capability to proliferate in concert with the uterine epithelium to form the only site for nutrient and metabolic exchange between the fetus and dam throughout pregnancy. Trophoblast is made up of a remarkable versatile epithelium showing great capacity for invasion, cell fusion, hormone production, specific nutrient absorption, selective transport, active metabolism, and has the ability to resist maternal immunological attack. These functions are attributed to its inherent ability to synthesize many developmental factors or molecular regulators. While there is an abundance of publications available on the structural, functional, and clinical relevance of the placenta in various mammalian species, a comprehensive review on the comparative aspects of the trophoblast of domestic and companion animals is lacking. Besides, a timely description on the clinical perspective on the functional aspects of the trophoblast in relation to pregnancy diagnosis, placental insufficiency, pregnancy loss, and structural abnormalities of domestic and companion animals is necessary. A brief description on the basic chronology of events in each animal is followed by the applied clinical perspectives of trophoblast. Both the above aspects of trophoblasts of domestic and companion animals including the terminologies are summarized in tables to facilitate discussion.

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Determination of Serum C-Reactive Protein (CRP) in Healthy Beagle Dogs of Various Ages and Pregnant Beagle Dogs

Cited by 61 publications

References 14 publications

Association of canine obesity with reduced serum levels of C-reactive protein

Association of canine obesity with reduced serum levels of C-reactive protein

Serum C‐Reactive Protein Concentration in Benign and Malignant Canine Spirocercosis

Trophoblast of domestic and companion nimals: basic and applied clinical perspectives

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