Determination of serum 25-hydroxyvitamin D levels in patients with alopecia areata and their comparison with levels in healthy controls: A cross-sectional study

Lizarondo, Felix Paolo J.; Gervasio, Mia Katrina R.; Chamberlin, Charmaine Vanessa S.; Gnilo, Charissa Mia S.; Silva, Claudine Y.

doi:10.1016/j.jdin.2021.07.008

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…In a cross-section study by Lizarondo et al 34% of patients with AA had vitD deficiency (25(OH)-D levels < 20ng/mL). In this study with 29 patients, the 25(OH)D levels were classified: Deficiency; <20ng/mL; Insufficiency: 21-29ng/mL; Sufficiency: 30-100ng/mL 30 . In a study by Lee et al 1255 AA subjects had mean 25(OH)D levels 8.5ng/mL lower than controls.…”

Section: Vitamin D Statusmentioning

confidence: 99%

Alemtuzumab-Induced Secondary Autoimmune Skin Disorders as Side Effects of Multiple Sclerosis Therapy: Problem That Can Be Influenced or Fate? A Narrative Overview of The Literature A Neuroprotective Role of Vitamin D?

Goischke¹

2022

MRAJ

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At present, no cure for multiple sclerosis can be made possible with the pharmaceuticals available, nor can a gradual progression of multiple sclerosis be prevented. In the management of multiple sclerosis, it is therefore necessary to determine existing autoimmune diseases through anamnesis before starting alemtuzumab therapy with disease modifying therapy. With previously existing autoimmune diseases or as prophylaxis, comorbidities can be influenced by vitamin D supplementation. Secured pathophysiological and immunological mechanisms of vitamin D on autoimmunological processes support the daily, individually high-dose oral vitamin D intake. This add-on therapy should positively influence the quality of life of persons with multiple sclerosis in the long term. So that the patients do not reject the highly efficient multiple sclerosis therapy for fear of side effects, this therapy offer is a way of avoiding side effects of alemtuzumab administration, such as alopecia, vitiligo, and thyroid diseases, and of decisively influencing the course of MS. This increases the compliance of the persons with multiple sclerosis in therapy. The pathophysiological mechanisms of alopecia and vitiligo are shown. The immunological mechanisms of vitamin D and its influence on autoimmune diseases are described. The previous use of vitamin D in the therapy of these skin diseases is presented and oral supplementation is put up for discussion. The additional neuroprotective effect is evident. Preventing infection with oral vitamin D supplements, particularly in coronavirus disease 2019, may prevent or mitigate multiple sclerosis exacerbations.

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Section: Vitamin D Statusmentioning

confidence: 99%

Alemtuzumab-Induced Secondary Autoimmune Skin Disorders as Side Effects of Multiple Sclerosis Therapy: Problem That Can Be Influenced or Fate? A Narrative Overview of The Literature A Neuroprotective Role of Vitamin D?

Goischke¹

2022

MRAJ

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“…Forest plot showing vitamin D in non-scarring alopecia.In contrast, Tran et al15 reported that patients with alopecia such as AA, FPHL or AGA did not show reduced serum 25(OH)D levels in comparison with healthy controls. A study found no significant differences in mean serum 25(OH)D levels or incidence of vitamin D deficiency between healthy controls and patients with alopecia areata (AA) 25. Many variables can affect the level of 25(OH)D in human serum, including country of residence, age, sex, exposure to sunlight, season, and sample size.…”

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confidence: 99%

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Chen,

Dong,

Wang

et al. 2023

J of Cosmetic Dermatology

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IntroductionNon‐scarring alopecia mainly includes androgenetic alopecia (AGA), female pattern hair loss (FPHL), alopecia areata (AA), telogen effluvium (TE), anagen effluvium (AE) and so on. Many studies had investigated the serum 25‐hydroxyvitamin D level and vitamin D deficiency of patients with these diseases, but opinions varied, and no conclusion was reached.MethodsRelevant articles were retrieved through PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and other databases. Serum 25‐hydroxyvitamin D [25(OH) D] levels and vitamin D deficiency were used as our primary outcome. The odds ratio (OR) and the standardized mean difference (SMD) with 95% confidence interval were both examined for vitamin D deficiency and levels.ResultsOur meta‐analysis had included a total of 3374 non‐scarring alopecia patients and 7296 healthy controls from 23 studies through the inclusion criteria and exclusion criteria. We found non‐scarring alopecia had decreased serum 25(OH)D level (WMD −7.29; 95% CI −9.21, −5.38) and increased vitamin D deficiency incidence (OR 3.11 95% CI 2.29, 4.22), compared with healthy controls. This meta‐analysis chose to conduct random‐effect model and subgroup analysis, because of the high heterogeneity (serum 25(OH)D level: I2 = 95%, vitamin D deficiency: I2 = 0%).ConclusionPatients with non‐scarring alopecia (including AA, FPHL, AGA and TE) have insufficient serum level of 25(OH)D and increased incidence of vitamin D deficiency. Vitamin D supplementation and monitoring for vitamin D deficiency may be helpful in treating non‐scarring alopecia.

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Trichoscopy pattern and evaluation of serum vitamin D status in alopecia areata

Alsenaid¹,

Alhetheli²,

AbdElneam³

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Determination of serum 25-hydroxyvitamin D levels in patients with alopecia areata and their comparison with levels in healthy controls: A cross-sectional study

Cited by 3 publications

References 44 publications

Alemtuzumab-Induced Secondary Autoimmune Skin Disorders as Side Effects of Multiple Sclerosis Therapy: Problem That Can Be Influenced or Fate? A Narrative Overview of The Literature A Neuroprotective Role of Vitamin D?

Alemtuzumab-Induced Secondary Autoimmune Skin Disorders as Side Effects of Multiple Sclerosis Therapy: Problem That Can Be Influenced or Fate? A Narrative Overview of The Literature A Neuroprotective Role of Vitamin D?

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Trichoscopy pattern and evaluation of serum vitamin D status in alopecia areata

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