Determination of selected cardiovascular active compounds in environmental aquatic samples – Methods and results, a review of global publications from the last 10 years

Stankiewicz, Albert; Giebułtowicz, Joanna; Stankiewicz, Urszula; Wroczyński, Piotr; Nałęcz‐Jawecki, Grzegorz

doi:10.1016/j.chemosphere.2015.07.056

Cited by 28 publications

(11 citation statements)

References 91 publications

(184 reference statements)

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“…Recent studies of ECs around the world [15,[65][66][67][68][69][70] have reported concentration values in the EWW in the same order as those found in this paper for the Vall de Uxó WWTP (Table SI-3, Supplementary material). The main differences between the EC values for the Vall de Uxó and those from previous works might be due to different consumption patterns of the citizens and the characteristics of the processes applied in the different WWTPs.…”

Section: Assessment Of the Occurrence Spatial Distribution And Concsupporting

confidence: 81%

Identification of Aquifer Recharge Sources as the Origin of Emerging Contaminants in Intensive Agricultural Areas. La Plana de Castellón, Spain

Renau‐Pruñonosa

García-Menéndez

Ibáñez

et al. 2020

Water

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In urban, industrial, and agricultural areas, a vast array of contaminants may be found because they are introduced into the aquifers by different recharge sources. The emerging contaminants (ECs) correspond to unregulated contaminants, which may be candidates for future regulation depending on the results of research into their potential effects on health and on monitoring data regarding their occurrence. ECs frequently found in wastewater, such as acetaminophen, carbamazepine, primidone, and sulfamethoxazole, may be good indicators of the introduction of the reclaimed water to the aquifers. The resistance of the ECs to removal in wastewater treatment plants (WWTPs) causes them to be appropriate sewage markers. Plana de Castellón (Spain) is a coastal area that has been characterized by intensive citrus agriculture since the 1970s. Traditionally, in the southern sector of Plana de Castellón, 100% of irrigation water comes from groundwater. In recent years, local farmers have been using a mixture of groundwater and reclaimed water from wastewater treatment plants (WWTPs) to irrigate the citrus. The aims of the present study were: (i) to assess the occurrences, spatial distributions, and concentrations of selected ECs, including 32 antibiotics, 8 UV filters, and 2 nonsteroidal anti-inflammatory drugs, in groundwater in a common agricultural context; (ii) to identify the recharge (pollution) sources acting as the origin of the ECs, and (iii) to suggest ECs as indicators of reclaimed water arrival in detrital heterogeneous aquifers. The obtained data provided relevant information for the management of water resources and elucidated the fate and behavior of emerging contaminants in similar contexts.

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Section: Assessment Of the Occurrence Spatial Distribution And Concsupporting

confidence: 81%

Identification of Aquifer Recharge Sources as the Origin of Emerging Contaminants in Intensive Agricultural Areas. La Plana de Castellón, Spain

Renau‐Pruñonosa

García-Menéndez

Ibáñez

et al. 2020

Water

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“…Hydrochlorothiazide was detected at levels up to 600 ng L −1 in surface waters and 3 μg L −1 in effluent waters by Batt et al (Batt et al, 2016). This is probably due in part to high prescription amounts for hydrochlorothiazide, but also due to its reduced metabolism (for instance, excretion rate as unchanged form is in the range of 80-99%) (Stankiewicz et al, 2015). Both, salbutamol and hydrochlorothiazide, were also previously detected in fish samples at very low concentrations (<20 ng g −1 , dry weight) (Huerta et al, 2013;Moreno-González et al, 2016;Valdés et al, 2016).…”

Section: Analysis Of Pharmaceuticals In Fishmentioning

confidence: 99%

Presence of pharmaceuticals in fish collected from urban rivers in the U.S. EPA 2008–2009 National Rivers and Streams Assessment

Huerta

Rodríguez-Mozaz

Lazorchak

et al. 2018

Science of The Total Environment

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Fish are good indicators of aquatic environment pollution because of their capability to uptake pollutants contained in water. Therefore, accumulation of pharmaceutical compounds in freshwater and marine fish and other aquatic organisms has been studied extensively in the last decade. In this context, the present study investigates the occurrence of pharmaceutical compounds in wild fish from 25 polluted river sites in the USA, downstream from wastewater treatment plants (WWTPs). Sample sites constitute a subset of urban rivers investigated in the U.S. EPA's 2008-2009 National Rivers and Streams Assessment. Thirteen pharmaceuticals (out of the twenty compounds analyzed) were quantified in fish fillets at concentrations commonly below 10ngg, in accordance with the findings from previous studies in the USA and Europe. The psychoactive drugs venlafaxine, carbamazepine and its metabolite 2-hydroxy carbamazepine were the most prevalent compounds (58%, 27% and 42%, respectively). This group of drugs is highly prescribed and rather resistant to degradation during conventional treatment in WWTPs as well as in natural aquatic environments. Salbutamol, a drug used to treat asthma, and the diuretic hydrochlorothiazide were also frequently detected (in >20% of the samples). Occurrence of six pharmaceutical families due to chronic exposure at environmental concentrations in water was detected in eight fish species.

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“…Sartans are mostly excreted as parent compounds, with percentages of metabolization below 25% (Bayer et al, 2014). Consequently, they are present in urban sewage water at concentrations in the ng per mL -1 range (Bodík et al, 2016;Oosterhuis et al, 2013;Stankiewicz et al, 2015). Their mass balances in conventional sewage treatment plants (STPs), equipped with primary and activated sludge units, showed variable, yet incomplete removal efficiencies.…”

Section: Introductionmentioning

confidence: 99%

Free chlorine reactions of angiotensin II receptor antagonists: Kinetics study, transformation products elucidation and in-silico ecotoxicity assessment

Carpinteiro

Castro

Rodrı́guez

et al. 2019

Science of The Total Environment

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Angiotensin II receptor antagonists (ARA II) are widely employed in the treatment of hypertension-related diseases. Because of their partial metabolization and limited biodegradability, these drugs have become ubiquitous pollutants in the aquatic environment, including surface water. This research evaluated the reactivity of the ARA II drugs: irbesartan (IRB), losartan (LOS) telmisartan (TEL) and valsartan (VAL) with free chlorine. Responses of parent compounds and their transformation products (TPs) were followed by liquid chromatography (LC) with quadrupole (Q) time-of-flight (TOF) mass spectrometry. Degradation experiments were carried out using ultrapure and river water samples, adjusted at different pHs and, in some cases, adding a small amount (ng mL level) of bromide salts. Whilst TEL and VAL remained stable in presence of relatively high concentrations of free chlorine (10 mg L), IRB and LOS were removed according to a pseudo-first order kinetics model. Considering an initial chlorine concentration of 10 mg L, their half-lives varied between 6 and 734 min, depending mostly on the water pH. IRB reacted with free chlorine through hydroxylation processes, with and without molecular cleavage and re-arrangements in the imidazolone ring. Its TPs showed a lower in-silico predicted toxicity than the parent drug. In case of LOS, two major competitive degradation routes were identified. They involved replacement of the methanol group attached to the imidazole cycle by chlorine or bromine, and the cleavage of this cycle with removal of the chlorinated carbon and the nitrogen in alpha position. The TPs generated following the first route are predicted to be more toxic than LOS.

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Determination of selected cardiovascular active compounds in environmental aquatic samples – Methods and results, a review of global publications from the last 10 years

Cited by 28 publications

References 91 publications

Identification of Aquifer Recharge Sources as the Origin of Emerging Contaminants in Intensive Agricultural Areas. La Plana de Castellón, Spain

Identification of Aquifer Recharge Sources as the Origin of Emerging Contaminants in Intensive Agricultural Areas. La Plana de Castellón, Spain

Presence of pharmaceuticals in fish collected from urban rivers in the U.S. EPA 2008–2009 National Rivers and Streams Assessment

Free chlorine reactions of angiotensin II receptor antagonists: Kinetics study, transformation products elucidation and in-silico ecotoxicity assessment

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