Determination of salivary levels of mucin and amylase in chronic periodontitis patients

Sánchez, G.; Miozza, Valeria; Delgado, Alejandra; Busch, Lucila

doi:10.1111/j.1600-0765.2010.01332.x

Cited by 63 publications

(94 citation statements)

References 20 publications

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“…Our study is in accordance with other studies which showed an increase in amylase levels in patients with gingivitis and periodontitis [5,13,16,17].…”

Section: Collection Of Salivasupporting

confidence: 93%

“…Salivary amylase is a calcium containing metalloenzyme that catalyses the hydrolysis of α [1,4] glycosidic bonding between glucose residues of polysaccharides such as starch, glycogen and dextrins [5,11]. In addition to its digestive action, α-amylase is also In the present study, an evaluation of mucins in unstimulated saliva was performed in healthy, gingivitis and chronic periodontitis subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Mucin estimation was performed using Alcian Blue method [5,8,9]. Briefly, saliva samples were taken in test tubes and diluted with distilled water.…”

Section: Collection Of Salivamentioning

confidence: 99%

“…One of the components of saliva are the salivary mucins which play a major role in modulation of oral flora, lubrication and tissue coating of oral hard and soft tissues [5]. Recent studies indicate that salivary mucin exhibits bactericidal activity against Aggregatibacter actinomycetemcomitans which is among the major pathogens responsible for periodontitis [6].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies indicate that salivary mucin exhibits bactericidal activity against Aggregatibacter actinomycetemcomitans which is among the major pathogens responsible for periodontitis [6]. Salivary amylase also exhibits inhibitory activity against various microorganisms [5]. Also, patients with periodontal disease have differences in the protein composition of whole saliva [2].…”

Section: Introductionmentioning

confidence: 99%

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Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients

Kejriwal

Bhandary

Thomas

et al. 2014

JCDR

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Background: Periodontal diseases are a group of inflammatory conditions resulting from interaction between a pathogenic bacterial biofilm and susceptible host's inflammatory response eventually leading to the destruction of periodontal structures and subsequent tooth loss. Hence, investigation of salivary proteins in individuals with periodontal diseases may be useful to enhance the knowledge of their roles in these diseases. Materials and Methods:This case-control study was conducted at A.B. Shetty Memorial Institute of Dental Sciences, Mangalore. The study comprised of 90 patients of age between 25-60 years who were clinically examined and divided into three groups of 30 each: namely clinically healthy, gingivitis and chronic periodontitis. These were classified according to the values of gingival index score, clinical attachment loss and probing pocket depth. Unstimulated saliva was collected and salivary mucin, amylase and total protein levels were determined. Statistical analysis:Results obtained were tabulated and statistically analyzed using ANOVA test and Karl pearson's correlation test. Results:The results of the study showed an increased concentration of salivary mucin, amylase and total protein in gingivitis patients and increased levels of amylase and total protein in saliva of chronic periodontitis patients compared to healthy individuals which were statistically significant. A decrease in mucin concentration was observed in the periodontitis group compared to gingivitis group. A positive correlation was present between salivary mucin, amylase and total protein levels in the three groups.Conclusion: Salivary mucin, amylase and total protein may serve as an important biochemical parameter of inflammation of the periodontium. Also, it can be hypothesized that various enzyme inhibitors might be useful as a part of host modulation therapy in the treatment of periodontal diseases.

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“…Our study is in accordance with other studies which showed an increase in amylase levels in patients with gingivitis and periodontitis [5,13,16,17].…”

Section: Collection Of Salivasupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…Mucin estimation was performed using Alcian Blue method [5,8,9]. Briefly, saliva samples were taken in test tubes and diluted with distilled water.…”

Section: Collection Of Salivamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients

Kejriwal

Bhandary

Thomas

et al. 2014

JCDR

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Effect of Chewing on the Expression of Salivary Protein Composition: A Systematic Review

Al‐Manei

Almotairy

Bostancı

et al. 2020

Proteomics Clinical Apps

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Salivary proteins have an imperative role in the maintenance of oral health and repairing mechanisms of injured tissues. However, there is paucity of information reported in the literature about the influence of chewing activities on the secretion or expression of salivary proteins. The purpose of this systematic review is to evaluate the effect of chewing on the expression of salivary proteins composition in healthy individuals. A thorough systematic search shows 14 eligible studies for the review. The results of the systematic review show the effect of chewing on total protein concentration, alpha-amylase ( -amylase), peroxidase, lysozyme, immunoglobulin A (IgA), and mucin. Six papers concluded that chewing has a little or no effect on total protein concentration, -amylase, peroxidase, lysozyme, and IgA activities. Five papers reported a negative (decreasing) effect of chewing on the function of total protein, -amylase, IgA, and mucin. Only two papers showed an increase in total protein and IgA function upon chewing stimulation. The results of this systematic review indicate that more standardized evidence-based research is required for better assessment of chewing effects on salivary proteins. Within the limitations of this review, the existing evidence suggests that chewing in healthy people has minimum effect on the expression and activities of salivary proteins.

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Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride

et al. 2022

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Determination of salivary levels of mucin and amylase in chronic periodontitis patients

Abstract: Periodontitis induces an increase in the output of proteins, including mucin and amylase, thereby enhancing the protective potential of saliva, but this is accompanied by a decrease in flow rate.

Cited by 63 publications

References 20 publications

Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients

Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients

Effect of Chewing on the Expression of Salivary Protein Composition: A Systematic Review

Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride

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