Determination of salicylic acid in human serum with capillary zone electrophoresis

Goto, Yoko; Makino, Kazutaka; Kataoka, Yasufumi; Shuto, Hideki; Oishi, Ryozo

doi:10.1016/s0378-4347(97)00569-0

Cited by 19 publications

(10 citation statements)

References 15 publications

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“…Therefore, the CZE analysis without the use of any surfactants has recently been developed as the more simple and rapid analysis of NSAID [15,16,24,[35][36][37][38][39][40][41][42][43]. The CZE analyses for antiinflammatory agents in human specimens, including serum and urine, and pharmaceuticals are summarized in Table 3.…”

Section: General Considerationsmentioning

confidence: 99%

“…The CZE analyses for antiinflammatory agents in human specimens, including serum and urine, and pharmaceuticals are summarized in Table 3. We have already developed a simple CZE assay for ibuprofen, acetaminophen, indomethacin, salicylic acid, and some salicylate metabolites such as gentisic acid and salicyluric acid in human serum after precipitation of serum proteins with acetonitrile [15,16]. The detection limit of each drug is in a few mg/mL range.…”

Section: General Considerationsmentioning

confidence: 99%

“…We have reported a sensitive assay for serum salicylic acid and other metabolites of aspirin by using capillary zone electrophoresis (CZE) coupled with a diode-array ultraviolet (UV) detector [15]. We have also applied the CZE method for the rapid and simultaneous determination of several anti-inflammatory agents, including ibuprofen, acetaminophen and indomethacin, or salicylic acid in human serum [16].…”

Section: Introductionmentioning

confidence: 99%

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Determination of nonsteroidal anti‐inflammatory drugs in human specimens by capillary zone electrophoresis and micellar electrokinetic chromatography

et al. 2004

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Therapeutic drug monitoring of anti-inflammatory drugs is necessary for the identification of the agents that cause toxic events and for the decision on the treatment for intoxication. Recently, capillary electrophoresis (CE) has been developed for the simple and rapid analyses of a variety of chemical agents. Micellar electrokinetic chromatography (MEKC) can separate acidic, neutral and basic anti-inflammatory drugs in serum. Furthermore, serum samples are directly applied to the CE system without any pretreatments, and some anti-inflammatory drugs can be separated from serum albumin in the MEKC analysis. On the other hand, capillary zone electrophoresis (CZE) enables us to determine a few microg/mL levels of acidic anti-inflammatory drugs with simple running buffer and stacking technique. A rapid and simultaneous determination of several analgesic anti-inflammatory agents, including ibuprofen, acetaminophen, indomethacin, and salicylic acid in human serum has been developed by using CZE. Therefore, the CZE and MEKC analysis may become a potentially useful alternative to high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA) for therapeutic drug monitoring, particularly in serum of patients suffering from intoxication by overdosage of nonsteroidal anti-inflammatory agents.

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Section: General Considerationsmentioning

confidence: 99%

Section: General Considerationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of nonsteroidal anti‐inflammatory drugs in human specimens by capillary zone electrophoresis and micellar electrokinetic chromatography

et al. 2004

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“…These include high-performance liquid chromatography (HPLC) coupled with chemiluminescence (CL) detection (7), cyclic voltammetry and differential pulse voltammetry (DPV) (8), capillary zone electrophoresis (CZE) with diode array detection (DAD) (9). However, in many cases, the disadvantages of these methods are limited analytical applications due to fewer CL reactions, interference from excess use of some derivatization reagents, undetectable compounds due to the incompatibility of the mobile phase with CL reactions (e.g.…”

Section: Introductionmentioning

confidence: 99%

Application of a lanthanide composite nanoparticle‐sensitized luminescence method for the determination of salicylic acid in pharmaceutical formulations and human plasma

2008

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Terbium-acetylacetone (Tb-acac) composite nanoparticles were synthesized using the ultrasonic method. The nanoparticles are water-soluble, stable and have extremely narrow emission bands and high internal quantum efficiencies. -4 mol/LSA was 1.75%. The method was applied to the determination of SA in pharmaceutical formulations and human plasma. We believe that the proposed approach has great potential for clinical purposes.

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“…Recommended therapeutic levels in plasma range from 150 to 300 mg.L -1 . However, symptoms of intoxication may appear at 300 mg.L -1 level, and severe sequelae of intoxication including tetany and acidosis may occur at levels more than 500 mg.L -1 (5). The degradation of salicylic acid and the genetic basis of the metabolism have been investigated for decades with various bacteria.…”

Section: Introductionmentioning

confidence: 99%

Salicylic acid degradation from aqueous solutions using Pseudomonas fluorescens HK44: parameters studies and application tools

Silva¹,

Valdman²,

Valdman³

et al. 2007

Braz. J. Microbiol.

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The optimal conditions for salicylic acid biodegradation by Pseudomonas fluorescens HK44 were determined in this study with the intention to create a microbial sensor. Kinetic experiments permitted a definition of 60 and 30min the time needed to achieve the maximum degradation of salicylic acid presented in a medium with and without yeast extract, respectively. The degradation in medium without yeast extract and the quantification by spectrophotometry 230 nm were selected to be used in further tests. The use of preactivated cells or on the exponential growth phase showed better salicylic acid degradation percentages when compared to nonactivated cells or on the stationary growth state. Finally, the best cellular concentration used on the salicylic acid degradation was 0,1 g.L -1. Strain HK44 shows to be capable of degrade salicylic acid presented in simple aqueous systems, making this strain a promising tool for the application on a luminescent microbial sensor.

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Determination of salicylic acid in human serum with capillary zone electrophoresis

Cited by 19 publications

References 15 publications

Determination of nonsteroidal anti‐inflammatory drugs in human specimens by capillary zone electrophoresis and micellar electrokinetic chromatography

Determination of nonsteroidal anti‐inflammatory drugs in human specimens by capillary zone electrophoresis and micellar electrokinetic chromatography

Application of a lanthanide composite nanoparticle‐sensitized luminescence method for the determination of salicylic acid in pharmaceutical formulations and human plasma

Salicylic acid degradation from aqueous solutions using Pseudomonas fluorescens HK44: parameters studies and application tools

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