Determination of salicylic acid in pharmaceutical formulations and foods by differential-pulse voltammetry using a glassy carbon electrode

Fung, YS; Luk, Shiu-Fai

doi:10.1039/an9891400943

Cited by 26 publications

(12 citation statements)

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“…Several methods are reported in literature, varying from colorimetry [5], fluorimetry [6] and chromatography [4,[7][8][9] to ion selective electrodes [10,11] and voltammetric methods [12]. Yet, the chromatographic analysis has a low sample throughput, and the other methods require lengthy sample pretreatment.…”

Section: Introductionmentioning

confidence: 99%

Determination of salicylate in beverages and cosmetics by use of an amperometric biosensor

Ehrendorfer

Sontag

Pittner

1996

Fresenius J Anal Chem

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A fast and selective enzymatic method for the determination of salicylate in beverages and cosmetics has been developed. The enzyme salicylate hydroxylase was immobilised covalently onto a glassy carbon working electrode of a wall-jet cell coupled with a flow-injection analysis system. The salicylate is enzymatically converted to catechol, which can be detected amperometrically on the glassy carbon electrode at +0.45 V. The response of the biosensor is linearly proportional to the concentration of salicylate between 725 nmol/l and 700 micromol/l. A high sample throughput (60 h(-1)) is possible, and the biosensor is stable for more than three months. Sample pretreatment for beverages and hair lotions is easy and fast. For creams, an extraction of salicylate is necessary. Relative standard deviations are less than 5.5% and the recoveries are between 95 and 105%.

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Section: Introductionmentioning

confidence: 99%

Determination of salicylate in beverages and cosmetics by use of an amperometric biosensor

Ehrendorfer

Sontag

Pittner

1996

Fresenius J Anal Chem

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“…Many analytical methods for SA determination have been described in literature, such as fluorescence spectrometry [5,6], high performance liquid chromatography [7], potentiometry [8], amperometry [9], voltammetry [10], and enzymatic methods [11,12]. However, most of the above mentioned methods need a series of sample pretreatments and high cost complicated operations or show poor efficiency.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric/amperometric detection of salicylic acid in water on carbon nanotubes-epoxy composite electrodes

Iacob¹,

Manea²,

Schoonman³

et al. 2015

WIT Transactions on the Built Environment

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This study aimed to develop the detection protocol for the quantitative determination of salicylic acid (SA) in water. A carbon nanotubes-epoxy composite (CNTE) electrode was tested for the development of the SA detection protocol. The electrochemical behaviour of SA on a CNTE electrode has been studied using the cyclic voltammetry (CV) technique. Also, the study of pH effect by CV showed that no significant effect was found. Differential-pulsed voltammetry (DPV) and square-wave voltammetry (SWV) techniques were employed for the optimization of the detection protocol. The optimized SWV technique application assumes the step potential of 0.005 V, the modulation amplitude of 0.05 V and the frequency of 50 Hz. In order to use this detection protocol for the in-field detection application, the possibility of using this composite electrode in real surface water without adding the supporting electrolyte has been tested. The same electroanalytical parameters for SA detection in real surface water and tap water were achieved without any interference, which denotes the microelectrode array behaviour of the composite electrode. This behaviour confers a great potential of this composite electrode for in-field direct detection of salicylic acid and also, for the indirect detection of acetylsalicylic acid from surface water.

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“…Several important studies reported the determination of ASA in pharmaceutical formulations based on its hydrolysis to salicylate at controlled temperature conditions, using unmodified or modified graphite [30,46], carbon paste [30] and glassy carbon [32,33,36,37,39,47] electrodes, and different supporting electrolytes, some of them having the inconvenience of methanol [30,33,36], diethylether, or ethanol-diethylether [37] content.…”

Section: Introductionmentioning

confidence: 99%

“…Acting as electroactive substance through salicylic acid, aspirin's main hydrolysis product, ASA has also been electrochemically studied from a mechanistic or analytical perspective, using a range of methods, electrode types, and, supporting electrolytes [12,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. International Journal of Electrochemistry Boron-doped diamond (BDD) is a very important material for electroanalysis, since it exhibits several electrochemically valuable properties such as its very wide electrochemical window in aqueous solutions resulting from the high overpotentials of the oxygen and hydrogen evolution reactions, low and stable voltammetric and amperometric background current, its excellent chemical and electrochemical stability in aggressive conditions, and its good responsiveness to a range of analytes without any conventional pretreatment [49][50][51][52][53][54][55][56][57][58][59].…”

Section: Introductionmentioning

confidence: 99%

Anodic Determination of Acetylsalicylic Acid at a Mildly Oxidized Boron-Doped Diamond Electrode in Sodium Sulphate Medium

Cofan

Radovan

2011

International Journal of Electrochemistry

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Differential pulse voltammetry (DPV) and chronoamperometry (CA) were used to detect and determine acetylsalicylic acid (ASA) at a mildly oxidized boron-doped diamond (BDD) electrode in a neutral sodium sulphate solution as supporting electrolyte. ASA determination in unbuffered medium was achieved using neutralized standard and real samples. Over the concentration range of 0.01 mM-0.1 mM, linear calibration plots of anodic current peaks in DPV and anodic currents in CA experiments versus concentration were obtained with very high correlation coefficients and good sensitivity values. The limits of detection were situated around 1 μM. The association of DPV and CA techniques with standard addition method represented a suitable option for the determination of ASA in real samples such as pharmaceutical formulations.

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Determination of salicylic acid in pharmaceutical formulations and foods by differential-pulse voltammetry using a glassy carbon electrode

Cited by 26 publications

References 0 publications

Determination of salicylate in beverages and cosmetics by use of an amperometric biosensor

Determination of salicylate in beverages and cosmetics by use of an amperometric biosensor

Voltammetric/amperometric detection of salicylic acid in water on carbon nanotubes-epoxy composite electrodes

Anodic Determination of Acetylsalicylic Acid at a Mildly Oxidized Boron-Doped Diamond Electrode in Sodium Sulphate Medium

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