Anodic Determination of Acetylsalicylic Acid at a Mildly Oxidized Boron-Doped Diamond Electrode in Sodium Sulphate Medium

Cofan, Codruţa; Radovan, Ciprian

doi:10.4061/2011/451830

Cited by 11 publications

(4 citation statements)

References 59 publications

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“…and reference value 79.4, as it can be seen again in entry 9 and entry 17. These results from the current technique considered better results compared to those from voltammetry [21] method regarding accuracy. Conversely, the accuracy and precision of both type of titration method were found very low compared to HPLC method.…”

Section: Resultsmentioning

confidence: 73%

Determination of Acetyl Salicylic Acid in Aspirin tablets

Ali

Salih

Hayder

2019

KJAR

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Drug analysis is an important method for determination of active components of any therapeutic drugs. HPLC, Spectrometry, Direct titration and Back-titration are common effective techniques in drug analysis. They were used in this study in a comparative way for the determination of the correct amount of acetyl salicylic acid in aspirin formulations. The aim of this study is to analysis of aspirin and compares both Direct titration and Back-titration techniques to the standard HPLC technique in order to find alternative, the easy and cheaper procedure to assess the quality of active components of medications aspirin in particular in Sulaimani city. Additionally, Spectrophotometric technique were also used and compared with the standard HPLC method. The samples were collected from different local drug stores in which distribute medications to pharmacies and they were from different companies. The analyses were performed after preparing a solution from each of the samples with a standard solutions for titration procedures. Both direct and back-titration techniques were used to find the concentration of active components in aspirin samples then compared with the data from standard HPLC as a reference value. The study showed that those companies which provide medications to this region were used a standard amount of acetyl salicylic acid in aspirin tablets. The result from Spectrophotometric method showed more accurate than both direct and indirect titration when compared to the reference value from standard HPLC technique due to the high rate of accuracy and precision of this method. However, the result also showed some inconsistent data in terms of the back titration compared to direct titration due to the inaccuracy in back titration. This study concluded with the necessity for quality control to use all these techniques for monitoring all medications which interring this region.

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Section: Resultsmentioning

confidence: 73%

Determination of Acetyl Salicylic Acid in Aspirin tablets

Ali

Salih

Hayder

2019

KJAR

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“…Stability testing of pharmaceutical products represents an important part in the drug development process because it provides evidence on how the quality of a drug substance varies with time, under the influence of a variety of environmental factors, such as temperature, humidity, and light [ 20 ]. Over the decades, many characterization techniques have been used for the detection of ASA, e.g., UV-VIS absorption spectroscopy [ 21 , 22 ], fluorescence [ 21 , 23 ], powder X-ray diffraction (PXRD) [ 24 , 25 ], FTIR spectroscopy [ 26 ], FT-Raman spectroscopy [ 27 ], X-ray photoelectron spectroscopy (XPS) [ 28 ], nuclear magnetic resonance (NMR) spectroscopy [ 29 ], high-performance liquid chromatography (HPLC) [ 30 , 31 ], and cyclic voltammetry (CV) [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Daescu

Iota

Serbschi³

et al. 2021

IJMS

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Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was reported. By exposure of the solution of ASA 0.3 M to UV light, a decrease in the PL band intensity was highlighted. This behavior was revealed for ASA in the presence of phosphate buffer (PB) having the pH equal to 6.4, 7, and 8 or by the interaction with NaOH 0.3 M. A different behavior was reported in the case of ASE. In the presence of PB, an increase in the intensity of the PL band of ASE simultaneously with a change of the ratio between the intensities of the bands at 361–364 and 394–397 nm was highlighted. The differences between PL spectra of ASA and ASE have their origin in the presence of salicylic acid (SAL). The interaction of ASE with NaOH induces a shift of the PL band at 405–407 nm. Arguments for the reaction of ASA with NaOH are shown by Raman scattering and FTIR spectroscopy.

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“…Spectrophotometric methods for amoxicillin [29], cloxacilln [30], ciprofloxacin [31], trimethoprim [32], albendazole [23], chloroquine [33], metronidazole [26] and for metformin [34] has been reported. Electrochemical methods for metronidazole [35], caffeine and theophylline [36], albendazole [37] and acetylsalicylic acid [38]; a kinetic method for amoxicillin [5] and a method using chemiluminescence for norfloxacin [39] are available in literature.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a single HPLC method for the determination of thirteen pharmaceuticals in bulk and tablet dosage form

Tegegne¹,

Chandravanshi²,

Zewge³

et al. 2021

Bull. Chem. Soc. Eth.

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The aim of this study was to develop and validate a high performance liquid chromatography (HPLC) method for the determination of thirteen selected pharmaceutical compounds (metformin, amoxicillin, chloroquine, theophylline, trimethoprim, caffeine, norfloxacin, ciprofloxacin, acetylsalicylic acid, doxycycline hyclate, metronidazole, albendazole and cloxacillin) in bulk and tablet dosage form. Chromatographic separation using a Kromasil C18 column, gradient elution with aqueous formic acid (0.1%), methanol and acetonitrile, a UV absorption wavelength of 250 nm and a mobile phase flow rate of 1 mL/min over a 22 min run time was optimized for complete separation of the selected target compounds. The method was validated and results for: linearity, precision, sensitivity, accuracy, speciﬁcity, suitability and method robustness were obtained and met the ICH guidelines. Calibration curve correlation coefficients ranged from 0.9985-0.9998 and the percentage relative standard deviations for repeated analysis was below 5%, indicating acceptable method precision. The limits of detection (LODs) and quantification (LOQs) ranged from 0.020-0.27 µg/L and 0.080-0.91 µg/L, respectively. The accuracy study yielded recoveries in the ranges 86.0-102% for pure compounds and 90.9-106% for compounds in tablet dosage form. The method is robust for small or deliberate changes to the chromatographic parameters and found to be appropriate for analysis of tablets for the determination of the thirteen pharmaceuticals. KEY WORDS: Pharmaceuticals, Bulk determination, Tablet dosage, High performance liquid chromatography, Method development, ICH guidelines Bull. Chem. Soc. Ethiop. 2021, 35(1), 17-31. DOI: https://dx.doi.org/10.4314/bcse.v35i1.2

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Anodic Determination of Acetylsalicylic Acid at a Mildly Oxidized Boron-Doped Diamond Electrode in Sodium Sulphate Medium

Cited by 11 publications

References 59 publications

Determination of Acetyl Salicylic Acid in Aspirin tablets

Determination of Acetyl Salicylic Acid in Aspirin tablets

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Development and validation of a single HPLC method for the determination of thirteen pharmaceuticals in bulk and tablet dosage form

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