Determination of Rizatriptan in Its Tablet Dosage Forms by Uv Spectrophotometric and Spectrofluorimetric Methods

Altınöz, Sacide; Uçar, Gülberk; Yıldız, Emrecan

doi:10.1081/al-120016538

Cited by 12 publications

(3 citation statements)

References 7 publications

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“…The proposed methods were successfully applied to the determination of RTB in two representative tablets Rizora-10 and Rizora-5. The results obtained are showed in Table 5 and were compared with those obtained by the reference method [17] by means of Student's t-and F-tests at 95% confidence level. The reference method consisted of the measurement of the absorbance of the tablet extract in water at 225 nm.…”

Section: Applications To Analysis Of Pharmaceutical Formulationsmentioning

confidence: 99%

“…Development of a rapid, sensitive, and selective method for the determination of RTB is essential for the analysis of drug in bulk, in drug delivery system and for release dissolution studies. A few methods are found in the literature for the determination of RTB in pharmaceuticals and include UV-spectrophotometry [14][15][16][17][18], spectrofluorimetry [17], HPLC when present alone [19,20] or in combination with other antimigraine drugs [21]. A microemulsion electrokinetic chromatography (MEEKC) has also been reported for the determination of RTB and its degradation products [5].…”

Section: Introductionmentioning

confidence: 99%

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Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate

Prashanth

Basavaiah

2012

ISRN Analytical Chemistry

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Rizatriptan is a new selective 5-HT 1B/1D agonist which is used in the treatment of migraine headaches. Two simple, rapid, accurate, and economical spectrophotometric methods are described for the determination of rizatriptan benzoate (RTB) in its pure form and pharmaceutical preparations. These methods are based on the charge-transfer complexation reaction between rizatriptan benzoate as n-electron donor and p-chloranilic acid (p-CA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π-acceptor to form highly colored chromogens. The chromogens formed by the reaction between RTB and p-CA peaked at 530 nm (method A) and that formed by the reaction between RTB and DDQ peaked at 590 nm (method B). Under the optimum conditions Beer's law is obeyed in the concentration range of 14-245 μg mL −1 for method A and 4-70 μg mL −1 for method B. The coefficient of correlation was found to be 0.9999 for both methods. The molar absorptivity, Sandell sensitivity, limits of detection, and quantification are also reported. The stoichiometric relationship determined by Job's continuous method was found to be 1 : 1 (drug : reagent) for both methods. Both methods were applied to determination of RTB in the pharmaceutical formulations. Results of the analysis were validated statistically.

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Section: Applications To Analysis Of Pharmaceutical Formulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate

Prashanth

Basavaiah

2012

ISRN Analytical Chemistry

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“…Literature revealed that, there is no reported UV method for its estimation till now. Hence present research work was aimed at development of accurate, precise UV-spectrophotometric method 3,4 for estimation of ivabradine hydrochloride.…”

Section: Introductionmentioning

confidence: 99%

Absorption Maxima and Uv-Spectrophotometric Method for Estimation of Ivabradine Hydrochloride

Jyothi¹,

Navya²

2018

Int. Res. J. Pharm.

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Ivabradine hydrochloride is a new drug approved recently by United State's Food and drug administration for treatment of chronic stable angina pectoris in coronary artery disease. As there is no reported simple UV spectrophotometric method for estimation of ivabradine hydrochloride, the aim of the present work was to develop simple, accurate and precise UV spectrophotometric method for estimation of ivabradine hydrochloride by absorption maxima method. pH 6.8 phosphate buffer was used as a solvent for ivabradine hydrochloride as it is freely soluble. 10 µg/ml solution of of ivabradine hydrochloride was used as working standard solution. The solution was scanned in the wavelength range of 200-400 nm against the reagent blank to obtain the absorption maxima using UV-visible Spectrophotometer. Clear peak absorbance appeared at 286 nm was considered as absorption maxima, λmax.. Calibration curve was constructed at 286 nm for dilutions containing 10, 20, 30, 40 and 50 μg/ml of ivabradine hydrochloride. The curve was obtained with 'r' value of 0.9984 indicating positive correlation between concentrations of Ivabradine hydrochloride and the corresponding absorbance values. The method obeys Beer's law in the range of 10-60 µg/ml. Low values of standard deviation (0.11) and standard error (0.034) indicated precision and accuracy of the method respectively.

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Sensitive and selective spectrophotometric assay of rizatriptan benzoate in pharmaceuticals using three sulphonphthalein dyes

Prashanth

Basavaiah

Vinay

2016

Arabian Journal of Chemistry

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Determination of Rizatriptan in Its Tablet Dosage Forms by Uv Spectrophotometric and Spectrofluorimetric Methods

Cited by 12 publications

References 7 publications

Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate

Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate

Absorption Maxima and Uv-Spectrophotometric Method for Estimation of Ivabradine Hydrochloride

Sensitive and selective spectrophotometric assay of rizatriptan benzoate in pharmaceuticals using three sulphonphthalein dyes

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