Absorption Maxima and Uv-Spectrophotometric Method for Estimation of Ivabradine Hydrochloride

Jyothi, J.; Navya, B

doi:10.7897/2230-8407.099205

Cited by 1 publication

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“…The sample was scanned by UV-VIS Spectrophotometer in the range of 200-400 nm, using respective solvent as a blank. The wavelength corresponding to the maximum absorbance (max) was found (Jyothi and Padmaja, 2016).…”

Section: Determination Of λMaxmentioning

confidence: 99%

Nanosponges loaded with 5-Fluorouracil for treatment of skin cancer

Kolte,

Pawar

2023

Asian J Pharm Pharmacol

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Cancer is a major cause of death in universe. Skin is the largest organ of human body, which also acts as a boundary between body and environment. It protects the body from chemical, physical, and microbial injury, loss of water, and other endogenous substances. Skin cancer is fatal public health concern rising in nonstop manner in all over the world. Absorption of drug through the skin is influenced by several factors like molecular size, lipophilicity, and pH of formulation, penetrate concentration, chemical enhancers, skin hydration, skin enzymes, temperature, formulation compositions etc and are discussed briefly.When drugs are applied on the skin surface, penetration into and through the skin can occur via various routes. Drugs penetrate either via the stratum corneum (trans epidermal) or via the appendages (trans appendageal). During penetration through the stratum corneum, two possible routes can be distinguished, (i) Penetration treating through the corneocytes and the lipid lamellae (transcellular route) and (ii) Penetration along the tortuous pathway along the lipid lamellae (intercellular route). Generally, it is accepted that the predominant route of penetration through the stratum corneum is the intercellular route. This is mainly caused by the densely cross-linked cornified envelope coating the keratinocytes. However transcellular transport for small hydrophilic molecules such as water cannot completely be excluded. The appendage route or shunt route includes either the duct of the eccrine sweat glands or the follicular duct. The content of the eccrine sweat glands is mainly hydrophilic, while the content of the follicular duct is lipophilic. This is mainly due to the sebum excreted into the opening of the follicular duct. It is generally accepted that due to its large surface area, passive skin permeation mainly occurs through intact stratum corneum (Prabhakar et al., 2013).Fluorouracil (5-FU) is a type of chemotherapy that exerts its anti-cancer effect by preventing the production of DNA in the cell. Lack of functional DNA prevents the cancer cell from reproducing and making vital proteins, which then results in death of the cell. Topical fluorouracil is used to treat actinic keratosis and superficial basal and squamous cell skin cancers. Topical chemotherapy with 5-FU is associated with the limitations of poor skin permeation, retention at target site, and skin irritation potential. Now a days nanoparticles of antibacterial agent are widely

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Section: Determination Of λMaxmentioning

confidence: 99%