Determination of Required HLB of Capryol 90

Rao, Monica R. P.; Aghav, Shital S.; Sukre, Girish; Kumar, Manmeet

doi:10.1080/01932691.2013.777824

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…The self-emulsification efficacy of Capryol 90 with various surfactant/co-surfactant combinations, such as Tween-20/PEG-400, Cremophor EL/Labrasol, Cremophor EL/Tween-80, and Cremophor RH40/PEG 400, has been reported [16][17][18]. The tested surfactants, Cremophor EL (HLB = 12-14) and RH40 (HLB = 14-16), were easily emulsified with the selected oil phase; these observations were consistent with those of a previous study by Rao et al [19] in which the required HLB of Capryol 90 was found to be 15. In addition, a previous study showed that Cremophor EL could enhance the bioavailability of drugs by modulating the efflux transportation of P-glycoprotein (P-gp) in isolated rat intestinal membranes [20].…”

Section: Discussionsupporting

confidence: 90%

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

et al. 2020

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Both quercetin and resveratrol are promising plant-derived compounds with various well-described biological activities; however, they are categorized as having low aqueous solubility and labile natural compounds. The purpose of the present study was to propose a drug delivery system to enhance the oral bioavailability of combined quercetin and resveratrol. The suitable self-microemulsifying formulation containing quercetin together with resveratrol comprised 100 mg Capryol 90, 700 mg Cremophor EL, 200 mg Labrasol, 20 mg quercetin, and 20 mg resveratrol, which gave a particle size of 16.91 ± 0.08 nm and was stable under both intermediate and accelerated storage conditions for 12 months. The percentages of release for quercetin and resveratrol in the self-microemulsifying formulation were 75.88 ± 1.44 and 86.32 ± 2.32%, respectively, at 30 min. In rats, an in vivo pharmacokinetics study revealed that the area under the curve of the self-microemulsifying formulation containing quercetin and resveratrol increased approximately ninefold for quercetin and threefold for resveratrol compared with the unformulated compounds. Moreover, the self-microemulsifying formulation containing quercetin and resveratrol slightly enhanced the in vitro antioxidant and cytotoxic effects on AGS, Caco-2, and HT-29 cells. These findings demonstrate that the self-microemulsifying formulation containing quercetin and resveratrol could successfully enhance the oral bioavailability of the combination of quercetin and resveratrol without interfering with their biological activities. These results provide valuable information for more in-depth research into the utilization of combined quercetin and resveratrol.

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Section: Discussionsupporting

confidence: 90%

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

et al. 2020

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“…LAE can form mixed micelles with Tween 20 (Asker et al, 2011), and the tail of LAE has a closer similarity to the laurate moiety of Tween 20 than the oleate of Tween 80 (McClements, 2004). The better surface activity synergy between LAE and Tween 80 than that of Tween 20 can possibly result from the lower hydrophilic-lipophilic balance (HLB) of Tween 80 (HLB = 15) than Tween 20 (HLB = 16.7) when CBO is emulsified and after heating and quenching (Lv et al, 2014;Rao et al, 2014). Both Ostwald ripening and coalescence can contribute to sedimentation of droplets observed for the emulsions prepared with Tween 20, due to growth of droplets during storage which was not measured due to instability of emulsions.…”

Section: Nanoemulsion Propertiesmentioning

confidence: 99%

Physical and antimicrobial properties of cinnamon bark oil co-nanoemulsified by lauric arginate and Tween 80

Hilbig

Davidson

et al. 2016

International Journal of Food Microbiology

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Lauric arginate (LAE) is a water-soluble cationic surfactant which has antimicrobial activity against a broad spectrum of foodborne pathogens. Some spice essential oils are effective lipophilic antimicrobials. Combining both antimicrobials may reduce their usage levels and possible negative sensory impacts when applied in complex food matrices. The objective of this study was to combine a nonionic surfactant (Tween 80) with LAE to form stable nanoemulsions with cinnamon bark essential oil (CBO) and to characterize the antimicrobial activity of these nanoemulsions. CBO was homogenized at 1% w/w in the aqueous phase with 3% w/w Tween 80 and 0.05-0.375% w/w LAE, followed by heating at 90°C for 30min to obtain final emulsions. With 0.125% and higher LAE, transparent emulsions with ~100nm in hydrodynamic diameter were observed to be stable during 30-day storage at 21°C. Antimicrobial activities of the nanoemulsion prepared with Tween 80 and 0.375% w/w LAE were studied. The respective minimum inhibitory concentrations (MICs) of the nanoemulsion in tryptic soy broth (TSB) were 12, 7, and 8ppm LAE for Salmonella enteritidis, Escherichia coli O157:H7, and Listeria monocytogenes, while those of free LAE were 11, 6, and 6ppm, respectively. MICs of CBO were 400ppm for the tested bacteria and Tween 80 at 6% w/w did not show inhibitory effect. Growth kinetics of the bacteria in TSB treated with the nanoemulsion or individual components at concentrations corresponding to the MICs of free LAE showed that binding among the LAE and Tween 80 and CBO components resulted in the antibacterial activity of nanoemulsion being lower than same concentrations of free LAE and CBO. Conversely, little difference was observed for the individual antimicrobials and the nanoemulsion in 2% reduced fat milk, and 750ppm LAE and 2000ppm CBO were observed to be the dominant antimicrobial against Gram-positive and Gram-negative bacteria, respectively. The growth of L. monocytogenes in 2% reduced fat milk at 4°C was not observed when treated by the nanoemulsion corresponding to 187.5ppm LAE and 500ppm CBO. Therefore, stable and transparent nanoemulsions of EOs can be prepared with the combination of LAE and Tween 80 without compromising antimicrobial activities.

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“…During the development of L-SNEDDS, psuedoternary diagram data revealed that wider phase regions in system I > system II > system III indicated a better self-emulsification ability [37], this was attributed to the required hydrophilic lipophilic balance (RHLB) value; when the RHLB of the oil is similar or matches the corrected HLB for surfactant/cosurfactant blend, a stable emulsion with lowest interfacial tension is obtained [38]. RHLB values for Capryol 90 and Capmul MCM are 15 and 12.84, respectively [39].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a combination of a high HLB value surfactant Cremophor El (HLB = 14) with a high HLB value cosurfactant Propylene glycol (HLB = 11.5) was also successful, but with relatively with lower emulsification region at lower oil concentration ranges (10-40%). As a result of component synergism, a larger area of emulsification was obtained by using Cremophor EL/Transcutol as the surfactant blend when compared to the area resulting from systems that use Cremophor EL/PG as surfactant blends [38,39]. However, Cremophor EL (HLB = 14) was able to promote self-emulsification to yield emulsions with fine droplets that were expected be rapidly emptied from the stomach upon dispersion [42].…”

Section: Discussionmentioning

confidence: 99%

Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet

et al. 2022

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Pioglitazone Hydrochloride (PGZ) suffers from poor aqueous solubility. The aim of this research was to design orally disintegrating tablets with self-nanoemulsifying properties (T-SNEDDS) to improve the Pioglitazone solubility and dissolution rate. Three liquid self-nanoemulsifying systems (L-SNEDDS) were formulated and evaluated for transmittance percentage, emulsification time, particle size, Poly dispersity index (PDI), percentage of content, solubility and stability. The optimum L-SNEDDS formula was converted to a solidified self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorption on Syloid (SYL). Powder characterization tests, such as flowability tests, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM), were performed for the selected S-SNEDDS formulation. Orally disintegrating tablets (ODT) were formulated by blending S-SNEDDS with tableting excipients. The ODT tablet batch composed of Prosolv was selected for tablet quality control tests, such as hardness, friability, disintegration time, content uniformity, weight variation, in vitro release, in vivo studies and accelerated stability studies. ODT tablets showed accepted mechanical properties and rapid disintegration time (<30 s). No drug degradation was observed at 3 months into the accelerated stability study. The optimized L-SNEDDS, S-SNEDDS and ODT (T-SNEDDS), showed significant enhancement of PGZ in vitro dissolution profiles compared to the pure drug (p > 0.05). In vivo pharmacokinetic and pharmacodynamic evaluation of ODTs showed better behavior compared to the raw drug suspension and the commercial tablet (p > 0.05). Orally disintegrating tablets revealed a promising potential to improve Pioglitazone poor aqueous solubility, dissolution profile and bioavailability.

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Determination of Required HLB of Capryol 90

Cited by 13 publications

References 17 publications

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

Physical and antimicrobial properties of cinnamon bark oil co-nanoemulsified by lauric arginate and Tween 80

Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet

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