Determination of rate constants of 1O2 consumption by 1O2 acceptors in weakly deactivating solvents

Opriel, Udo; Seikel, K.; Schmidt, Reinhard H.; Brauer, H.‐D.

doi:10.1016/1010-6030(89)87128-x

Cited by 40 publications

(12 citation statements)

References 18 publications

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“…As the oxygen concentration was gradually increased to 1% the toxicity induced by PIT rapidly increased, reaching a maximum at an oxygen content of 4% with no further increases in toxicity above 4% oxygen content. These results suggest that oxygen is an essential component of PITin agreement with previous reports [13,44,46,51]. …”

Section: Resultssupporting

confidence: 93%

“…(Figure 4A,4B) The lipophilic singlet oxygen scavenger offered more efficient protection against PIT than the hydrophilic sodium azide because the latter was excluded from the cell membrane while the former had ready access to the cell membrane. These results suggest that similar to PDT, oxygen may be a required component for inducing cell death with PIT [13,51]. When the ROS scavenger, butylated hydroxyl toluene (BHT)[22] was tested for protective effects in IR-700-Pan mediated PIT, no changes in cytotoxicity in A431 cells was noticed (Figure 4C).…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700–antibody conjugates

Kishimoto

Bernardo

Saito

et al. 2015

Free Radical Biology and Medicine

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Photoimmunotherapy (PIT) using the near infrared-absorbing photosensitizing phthalocyanine dye, IRDye 700DX (IR700) conjugated with a tumor-targeting antibody such as Panitumumab (Pan) has shown efficacy in vitro studies and several pre-clinical models in mice with promise for clinical translation. PIT results in rapid necrotic cell death in vitro and tumor shrinkage in vivo. Photochemical studies with the Pan-IR700 conjugate showed that this agent can support generation of singlet oxygen and also generate reactive oxygen species after exposure to near infra-red (NIR) light. Moreover, in vitro studies using A431 cells, singlet oxygen scavengers abrogated the efficacy of PIT with Pan-IR700, while oxygen depletion to undetectable levels in an exposure chamber almost completely inhibited the cellular cytotoxicity of PIT. Survival of tumor bearing mice was prolonged in PIT treated animals but mice whose tumors were made transiently hypoxic prior to PIT had no benefit from the treatment. The results from this study support a central role for molecular oxygen derived species in cell death caused by PIT.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700–antibody conjugates

Kishimoto

Bernardo

Saito

et al. 2015

Free Radical Biology and Medicine

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“…53-54 Progressive loss in clonogenicity was seen when tumors were left in the host for increasing durations; this corresponded to progression of PDT-induced hypoxia as determined radio-biologically. Hypoxia sufficient to preclude direct tumor cell killing was identified at sub-curative PDT doses.…”

Section: Antivascular Effects Of Pdtmentioning

confidence: 99%

Photodynamic therapy of cancer: An update

Agostinis

Berg

Cengel

et al. 2011

CA: A Cancer Journal for Clinicians

4,223

3,792

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Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative particularly in early-stage tumors. It can prolong survival in inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.

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“…The tumoricidal activity of PDT is caused by direct cell damage and microvascular injury 2–4. PDT has been used for the management of various intraocular tumors including circumscribed5–8 and diffuse choroidal hemangioma,5–9 choroidal melanoma,10–12 retinal hemangioblastoma,13–16 retinal vasoproliferative tumor,1718 and retinal astrocytoma 19–21.…”

Section: Introductionmentioning

confidence: 99%

Transient increased exudation after photodynamic therapy of intraocular tumors

Mashayekhi

Shields

2013

Middle East Afr J Ophthalmol

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To report transient increased exudation after photodynamic therapy (PDT) of three different intraocular tumors (retinal hemangioblastoma, retinal astrocytoma, amelanotic choroidal melanoma). PDT with verteporfin (6 mg/m2 body surface area) was delivered at a dose of 50 J/cm2 and intensity of 600 mW/cm2 over 83 s. All patients experienced decreased vision within a few days following PDT. Optical coherence tomography showed development of subfoveal fluid in all cases and noncystoid intraretinal edema in the eye with juxtapapillary retinal hemangioblastoma. There was complete absorption of retinal/subretinal fluid with improvement of visual acuity to 20/20 in all cases between 3 weeks to 4 months after PDT.

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Determination of rate constants of 1O2 consumption by 1O2 acceptors in weakly deactivating solvents

Cited by 40 publications

References 18 publications

Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700–antibody conjugates

Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700–antibody conjugates

Photodynamic therapy of cancer: An update

Transient increased exudation after photodynamic therapy of intraocular tumors

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