Transient increased exudation after photodynamic therapy of intraocular tumors

Abstract

To report transient increased exudation after photodynamic therapy (PDT) of three different intraocular tumors (retinal hemangioblastoma, retinal astrocytoma, amelanotic choroidal melanoma). PDT with verteporfin (6 mg/m2 body surface area) was delivered at a dose of 50 J/cm2 and intensity of 600 mW/cm2 over 83 s. All patients experienced decreased vision within a few days following PDT. Optical coherence tomography showed development of subfoveal fluid in all cases and noncystoid intraretinal edema in the eye with juxtapapillary retinal hemangioblastoma. There was complete absorption of retinal/subretinal fluid with improvement of visual acuity to 20/20 in all cases between 3 weeks to 4 months after PDT.

Clinical use of photodynamic therapy in ocular tumors

“…140 In 25 of 27 reported cases, there was tumor regression and resolution of exudates (93% response) and stabilization or improvement of visual acuity occurred in 16 cases (59% success). As for complications, there was a transient increase in subretinal fluid in seven cases (26%), 50,118,140,154,166,171,193 intravitreal hemorrhage in three eyes (7%), 16,140,186 fibrosis and macular pucker in two cases (5%) 2 and exudative retinal detachment in one case. 215 The average follow-up time of the 25 cases for which information is available was 14.2 months.…”

“…Barbazetto et al, 24 Campbell et al, 42 CanalFontcuberta et al, 43 Donaldson et al, 57 Mashayekhi et al, 118 Rundle et al, 153 Soucek et al, 185 Eskelin et al, 62 Mashayekhi et al, 118 Mennel et al, 120 …”

“…Aaberg et al, 2 Atebara et al, 14 Baba et al, 16 Caminal et al, 41 Cheung et al, 50 Golshevsky et al, 70 Mashayekhi et al, 118 Mennel et al, 121 Papastefanou et al, 140 Sachdeva et al, 154 Saito et al, 157 Schmidt-Erfurth et al, 166 Selver et al, 171 Stattin et al, 186 Suh et al, 191 Szabo et al, 193 Wong et al, 215 Ziemssen et al 226 …”

Photodynamic therapy-induced acute exudative maculopathy in a case of choroidal haemangioma

“…PDT is based on the interaction of light with a photosensitiser leading to release of reactive oxygen species and resultant oxidative damage to the target tissue 3. PDT has been used for the management of various intraocular tumours like circumscribed and diffuse choroidal haemangiomas, choroidal melanomas, retinal haemangioblastomas, retinal vasoproliferative tumours and retinal astrocytomas 1 2…”

“…Photodynamic therapy (PDT) is used in treating various retinal conditions like choroidal neovascular membranes (CNVMs), polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathies. It is also used for treatment of intraocular tumours like circumscribed and diffuse choroidal haemangiomas, choroidal melanomas and retinal vasoproliferative tumours 1 2…”