Determination of pravastatin sodium by analytical Spectrophotometry

Antakli, Saad; Nejem, Leon; Kullah, Ahmad

doi:10.5958/0974-360x.2021.00129.3

Cited by 2 publications

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“…Fluvastatin (C 24 H 26 FNO 4 ) is a white crystalline powder that inhibits the enzyme hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, a rate-limiting step in cholesterol biosynthesis that transforms HMG-CoA to mevalonate [45][46][47][48] .…”

Section: Fig 3: Chemical Structure Of Simvastatinmentioning

confidence: 99%

“…It is sold under the brand name Lescol XL. HPLC 45,46 , capillary electrophoresis 47, and spectrophotometry [48][49][50][51] have all been used to create analytical procedures for determining Fluvastatin Table 4.…”

Section: Fig 3: Chemical Structure Of Simvastatinmentioning

confidence: 99%

“…In pill form, it act as prastatin and pravator. HPLC 57,58,59,61 , capillary electrophoresis 54 , LC-UV 55 and Spectrophotometry 56,57,60 were used to create analytical procedures for determining Pravastatin Table 5.…”

Section: Fig 4: Chemical Structure Of Fluvastatinmentioning

confidence: 99%

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2023

IJPSR

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Statins are the first line of defense in the treatment of dyslipidemia and hypercholesterolemia illness. HMG-CoA reductase inhibitors or statins are the most widely prescribed drugs for persons at risk of cardiovascular disease. Cardiovascular disease (CVD) is the leading cause of death and a major cause of morbidity around the world. Statins have the same mechanism of action, but their chemical structures, pharmacokinetic profiles, and lipid-modifying potency differ. Triglycerides, cholesterol, and low-density lipoprotein (LDL) levels in the blood are all known risk factors for vascular disease, but statin drugs help to increase high-density lipoprotein (HDL) levels in our bloodstream. Some of the drugs utilized include rosuvastatin, atorvastatin, simvastatin, and pravastatin. According to clinical data, rosuvastatin is the most effective drug for decreasing low-density lipoprotein cholesterol and triglycerides, followed by atorvastatin, simvastatin and pravastatin. A brief review of the analytical methods developed from 2001-2021 for the estimation of Antilipidemic drugs has been discussed in the present study. This study will help the researchers to develop better methods for this class of drugs.

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Section: Fig 3: Chemical Structure Of Simvastatinmentioning

confidence: 99%

Section: Fig 3: Chemical Structure Of Simvastatinmentioning

confidence: 99%

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2023

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Atorvastatin induced liver injury: A Case Series

Sreenivasan

Vijayan

et al. 2022

RJPT

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Atorvastatin is the most widely used statin for the prevention and treatment of cardiovascular disease. It belongs to the class of drugs called HMG-CoA reductase inhibitors. One of the most significant side effects of statins is liver injury. Liver injury as evidenced by elevation in liver enzymes occurs in some patients treated with atorvastatin 10mg to 80mg. Therefore, Liver function tests (LFTs) need to be assessed before initiating atorvastatin therapy and to be repeated thereafter. Here we discuss three cases of liver enzyme elevations within 24hrs of atorvastatin treatment. Liver enzymes were completely returned to baseline after discontinuing the therapy. The risk factors of atorvastatin induced liver injury are increased age, chronic diseases, and coadministration of drugs metabolised by Cytochrome P450 3A (CYP3A) enzyme.

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Determination of pravastatin sodium by analytical Spectrophotometry

Cited by 2 publications

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Atorvastatin induced liver injury: A Case Series

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