Determination of Potential Cellular Proliferation in the Odontogenic Epithelia of the Dental Follicle of the Asymptomatic Impacted Third Molars

The Use of Proliferation Markers of the Infamatuar and Developmental Odontogenic Cysts

“…Therefore authors suggested that MCM-2 is a valuable diagnostic tool for cystic transformations. [64][65][66] As a result of the literature review, the need of implementing histopathological, immunohistochemical, and clinical studies examining larger number of cases arises as a common view. These should investigate the proliferative potential of developmental and inflammatory cysts directed to improve the diagnosis and prognosis of lesions through association of findings with the clinical parameters.…”

“…They also observed a greater expression in inflammatory follicles and discussed this elevation is supporting the view that epithelial structures in DF have an increased cell turnover. 64 Another research investigating the levels of markers Ki-67 ve MCM-2, has explained the high expression of MCM-2 by lack of Ki-67 expression during the early G0 and early G1 phases of cell-cycle. 65 Therefore MCM-2 expressions are reported to provide more precise results in cytological diagnosis.…”

Pericoronal radiolucencies with significant pathology: Clinico-histopathologic evaluation

“…[8][9][10] Radiographic studies have reported cyst development in impacted third molars to occur at rates between 1% and 1.6% and epidemiological studies have reported the rates as between 0.0002% and 2.31%. [10][11][12][13] However, radiographic and clinical analysis of dental follicles may not always agree with histopathologic findings, [14][15][16][17][18] and the absence of symptoms does not necessarily imply the absence of pathology. [18] Miller and Bean suggested that disease may be present in minute follicular spaces, whereas areas of enlarged radiolucency may be histologically normal, making biopsy imperative.…”

Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars

“…The use of cell proliferating markers, such as integrins (Godoy et al, 2007), Ki-67 (Cabbar et al, 2008;Edamatsu et al, 2005) and PCNA (Adelsperger et al, 2000), has shown that the squamous metaplasia would be the first visible sign of cystic transformation of the DF and not a normal change due to advanced age. In our study, although we have not found a statistical association between PTCH labeling and the type of epithelial lining, probably due to the low number of PTCH-positive cells, the specimens with squamous metaplasia had higher rates of positivity for PTCH than DF with reduced enamel epithelium.…”