Determination of plasma theophylline by straight-phase high-performance liquid chromatography: Elimination of interfering caffeine metabolites

Aerde, Ph. Van; Moerman, E; Severen, R. Van; Braeckman, P

doi:10.1016/s0378-4347(00)84148-1

Cited by 29 publications

(1 citation statement)

References 30 publications

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“…After the pre-treatment and extraction steps, a wide range of analytical techniques have been used for the analysis and quantification of the main methylxanthines including capillary gas chromatography (GC) [81], gas chromatography-mass spectrometry (GC-MS) [82,83], spectrophotometry [77,84,85,86], Fourier transform-Raman spectrometry [87], spectrofluorimetry [88,89], Fourier transform-infrared spectrophotometry [90], capillary electrophoresis (CE) [91,92,93] and micellar electrokinetic electrophoresis (MEKC) [94,95,96], voltammetry [97,98], radioimmunoassay (RIA) [99,100], thin-layer chromatography (TLC) [68,101,102] ion-exchange chromatography [103] and even solid-phase ultraviolet sensing [104]. Supercritical fluid extraction, specifically using supercritical carbon dioxide and ethanol, has been proved to be an effective method for methylxanthine analysis from a number of different samples/sources (guaraná seeds, maté leaves, and cocoa beans) [73].…”

Section: Extraction Identification and Quantificationmentioning

confidence: 99%

Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks

et al. 2016

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Abstract:Methylxanthines are a group of phytochemicals derived from the purine base xanthine and obtained from plant secondary metabolism. They are unobtrusively included in daily diet in common products as coffee, tea, energetic drinks, or chocolate. Caffeine is by far the most studied methylxanthine either in animal or epidemiologic studies. Theophylline and theobromine are other relevant methylxanthines also commonly available in the aforementioned sources. There are many disseminated myths about methylxanthines but there is increased scientific knowledge to discuss all the controversy and promise shown by these intriguing phytochemicals. In fact, many beneficial physiologic outcomes have been suggested for methylxanthines in areas as important and diverse as neurodegenerative and respiratory diseases, diabetes or cancer. However, there have always been toxicity concerns with methylxanthine (over)consumption and pharmacologic applications. Herein, we explore the structure-bioactivity relationships to bring light those enumerated effects. The potential shown by methylxanthines in such a wide range of conditions should substantiate many other scientific endeavors that may highlight their adequacy as adjuvant therapy agents and may contribute to the advent of functional foods. Newly designed targeted molecules based on methylxanthine structure may originate more specific and effective outcomes.

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Section: Extraction Identification and Quantificationmentioning

confidence: 99%

Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks

et al. 2016

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Determination of purine alkaloids and trigonelline in instant coffee and other beverages using high performance liquid chromatography

1983

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A simple, rapid high performance liquid chromatography method is reported for the simultaneous analysis of trigonelline and caffeine (1,3,7-trimethylxanthine) in coffee, and theobromine (3,7-dimethylxanthine) and caffeine in samples of cocoa, drinking chocolate, tea and cola. Chromatography was carried out on Spherisorb-ODS columns with gradient elution. The eluate was monitored at 272 nm with an ultraviolet spectrophotometer and quantification was achieved with external standards. Results for different brands of instant coffees, one decaffeinated coffee, and for samples of cocoa, drinking chocolate, tea and cola are reported.

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A method for the determination of theophylline in serum by isotope dilution mass spectrometry

Susanto

Humfeld

Niederau

et al. 1992

Fresenius J Anal Chem

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Determination of plasma theophylline by straight-phase high-performance liquid chromatography: Elimination of interfering caffeine metabolites

Cited by 29 publications

References 30 publications

Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks

Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks

Determination of purine alkaloids and trigonelline in instant coffee and other beverages using high performance liquid chromatography

A method for the determination of theophylline in serum by isotope dilution mass spectrometry

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