Determination of pioglitazone, its metabolite and alogliptin in human plasma by a novel LC-MS/MS method; application to a pharmacokinetic study

Determination of pioglitazone hydrochloride by flow injection chemiluminescence tris(2,2′‐bipyridyl)ruthenium(II)–silver(III) complex system

“…The calibration plot between PG-HCl concentration (in mg L À1 ) taken as abscissa and CL intensity peak height (in millivolts) taken as ordinate was linear over the range 0.001-5. FI-Spec 0.5-10 0.26 NR <1.09 [10] FI-Spec 0.5-15 0.14 0.46 <1.1 [11] Spec-FL 0.005-1.3 0.00161 0.00487 0.60 [12] Spec-FL 0.02-0.06 0.0102 0.0309 NR [13] Voltammetry 0.0039-39.29 0.00317 0.00963 <2.0 [14] Voltammetry HPLC-UV 0.25-10 0.08 0.25 2.7 [19] HPLC-UV 3-15 0.047 0.1427 <2.0 [23] LC-MS/MS 0.01-0.05 0.001 NR 18.8 [24] LC-MS/MS 0.01-3 0.01 NR 2.1-3.8 [25] HPTLC 60-600 ng band À1 8.51 ng band À1 25.77 ng band À1 0.51 [26] RP-TLC 40-240 6.0 20 0.66-1.09 [27] FI-CL 0.05-3.0 0.01 0.05 <2.0 [44] FI-CL 0.001-5.0 2.2 Â 10 À4 6.7 Â 10 À4 1.0-3.3 This method Spec, spectrophotometry: NR, not reported; FI-Spec, flow injection-spectrophotometry; Spec-FL, spectrofluorometry; CE, capillary electrophoresis; MEKC, miceller electro-kinetic chromatography; HPLC-UV, high-performance liquid chromatography-ultraviolet; LC-MS/MS, liquid chromatography-tandem mass spectrometry; HPTLC, high-performance thin layer chromatography; RP-TLC, reversed phase-thin layer chromatography; FI-CL, flow injectionchemiluminescence; LOD, limit of detection; LOQ, limit of quantification; RSD, relative standard deviation.…”

“…Table 2 summarizes calibration data of previously published procedures [8,[10][11][12][13][14][15][16][17][18][19][23][24][25][26][27]44] for the quantification of PG-HCl in medicinal samples and compares them with the present FI approach. The results were comparable to or even better than most results obtained from the reported methods.…”

“…[2,3] Although, PG remains excellent in the treatment of DM-2, its use has certain disadvantages: weight gain, obesity, fluid retention, anemia, peripheral edema, congestive heart failure, cholestatic hepatitis and an increase in fracture risk. [4][5][6] Numerous instrumental techniques have been described to quantify PG-HCl in medicinal and biological samples including batch and/or flow injection (FI) based ultraviolet-visible (UV-vis) spectrophotometry, [7][8][9][10][11] spectrofluorometry, [12,13] voltammetry, [14,15] potentiometry, [16,17] capillary electrophoresis (CE), [18] micellar electrokinetic chromatography (MEKC), [19] high-performance liquid chromatography with ultraviolet detectors (HPLC-UV), [19][20][21][22][23] liquid chromatography-tandem mass spectrometry (LC-MS/MS), [24,25] highperformance thin-layer chromatography (HPTLC), [26] reversed phase-TLC [27] and surface enhanced Raman scattering (SERS) spectrometry. [28] A few of these instrumental methods have good sensitivity and precision, but they require time consuming procedures, large volumes of solvents, complex instrumentation, multiple sample preparation steps and longer analysis times.…”

Development of Capillary Zone Electrophoresis Method for the Simultaneous Separation and Quantification of Metformin and Pioglitazone in Dosage Forms; and Comparison with HPLC Method

“…The literature reveals that various separation methods were used for the individual determination of MET [ 14 ] and with other diabetic drugs [ 15 , 16 , 17 ]. In addition, several chromatographic methods were reported for the determination of PIO, either alone [ 18 , 19 ] or with its main metabolites [ 20 , 21 ], besides in combination with other drugs [ 22 , 23 , 24 ].…”

Densitometric simultaneous assessment of teneligliptin hydrobromide and pioglitazone hydrochloride in combined tablet

“…A review of the existing literature focusing on the quantitative analysis of TGT and PGZ indicated that efforts have been directed toward devising analytical methods for these individual drugs, as well as in combination with other medications. These efforts have resulted in developing various methods including UV spectroscopy [3,[12][13][14][15], HPLC [2,3,7,[16][17][18][19][20][21][22][23], high-performance thin-layer chromatography (HPTLC) [15,[24][25][26][27][28][29], and LC-MS [23,[30][31][32][33][34][35][36]. Among the various methods that have been reported, the work by Gheewala et al in 2017 provided a comprehensive account of simultaneously determining TGT and PGZ within a synthetic mixture using both UV spectroscopy and HPLC.…”