Determination of Phenylephrine Hydrochloride in Combination with Other Drugs

Quantitative Determinations of Phenylephrine and Phenylpropanolamine Hydrochlorides in Combination

“…Methods of analysis for resorcinol monoacetate reported in the literature have included UV absorption (1,2) and photometry after reaction with picric acid (3) or p-dimethylaminobenzaldehyde (4). Paper chromatography and TLC techniques have also been used extensively (5, 6), and methods describing the use of GLC for phenolic compounds have been reported (7,8). None of these methods has been used for the quantitative determination of resorcinol monoacetate in a pharmaceutical matrix.…”

Ultraviolet spectrometry

“…In a study of the detection and determination of phenothiazine drugs in urine it was found that most could be recovered by distillation and recognized by their ultraviolet spectra (373). Among the applications of ultraviolet spectrophotometry to pharmaceutical analysis are a direct determination of niacin in drug mixtures (106), determination of morphine in paregoric using extraction (360) and partition chromatographic (354) separation, determination of strychnine in commercial bait formulations by extraction and calculation from the difference in absorbance at 254 and 287 µ (394), determination of tetracycline hydrochloride in the presence of anhydrotetracycline and epianhydrotetracycline by an absorbance ratio technique (306), determination of salicylamide, acetaminophen, and caffeine in mixtures by direct measurement of absorbances at different pH values (343), determination of droperidol, a tranquilizer, in the presence of fentanyl using extraction (197), determination of mephobarbital and diphenylhydantoin in tablets after chromatographic separation (95), determination of acetaminophen, phenylephrine hydrochloride, codeine phosphate, and pyrilamine maleate in tablets after partial separation by ion exchange chromatography (89), determination of allopurino after separation from alkaline decomposition products by ion exchange chromatography (158), determination of carbinoxamine maleate after separa-tion from other drugs using a carboxymethylcellulose column (279), determination of phenylephrine hydrochloride after separation from other drugs by partition chromatography (314), determination of chlorpheniramine in the presence of other drugs after separation by partition chromatography (318), and analysis of anovulatory formulations for gestogens using separation by extraction (213) and for progestins and estrogens using separation by gel filtration (123). Single tablets of isoxsuprine hydrochloride were assayed using an automatic analyzer system (47).…”