GLC Determination of Phenylephrine Hydrochloride in Human Plasma

Dombrowski, Lawrence J.; Comi, Patrick M.; Pratt, Edward L.

doi:10.1002/jps.2600621104

Cited by 18 publications

(3 citation statements)

References 16 publications

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“…Also, it is a decongestant, working by constricting blood vessels in the body. So far, there are several methods for determining PE in plasma, urine or tablet, such as gas chromatography (GC), 8 HPLC, 9 and GC-mass spectrometry (MS). 10 Most of these methods require a pretreatment of the separation steps and elaborate instruments.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

et al. 2009

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Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and cross-linking varied. When the ratio was 4:40, the surface morphology between the imprinted electrode (M-electrode) and the control electrode (N-electrode) became unambiguously different. This artificial receptor exhibited high selectivity for the template compared to closely related analogue. The response of the sensor varied in different concentration range might due to the heterogeneity of the MIPs membrane. This sensor was also used to determine phenylephrine in tablet samples.

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Section: Introductionmentioning

confidence: 99%

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

et al. 2009

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“…The various HPLC methods to measure PE in raw material and in dosage forms are not sensitive enough to determine low concentrations in biologic fluids. Gas chromatographic techniques have successfully monitored concentrations in biologic fluids, but they are often tedious to 47 Radiolabeled PE has been used to study PE p h a r m a c o k i n e t i~s~~ and rnetab01ism.~~ Some success has been attained with HPLC and solid phase extraction using either f l~o r o m e f r i c~~ or e l e c t r~c h e m i c a l~~ detection. An earlier study described a fluorometric method for determining PE in serum52 (Table 3).…”

Section: Pementioning

confidence: 99%

Pharmacokinetics of Oral Decongestants

1993

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Only three drugs are commonly used as oral decongestants—phenylpropanolamine (PPA), pseudoephedrine (PDE), and phenylephrine (PE). They are all chiral drugs that exist as stereoisomers. It is possible that each enantiomer can reflect significant enantioselective differences with regard to both pharmacokinetic and pharmacodynamic effects. Both PPA and PDE are readily and completely absorbed, whereas PE, with a bioavailability of only approximately 38%, is subject to gut wall metabolism and is thought to be absorbed erratically. Peak concentrations are reached between 0.5 and 2 hours after administration. All three drugs are extensively distributed into extravascular sites (apparent volume of distribution between 2.6 and 5.0 L/kg). No protein‐binding data in humans are available. Whereas PPA and PDE are not substantially metabolized, PE undergoes extensive biotransformation in the gut wall and the liver. Elimination of PPA and PDE is predominately renal, with urinary excretion being pH dependent. Half‐lives are relatively short, approximately 2.5 hours for PE, 4 hours for PPA, and 6 hours for PDE. Elimination of PPA and PDE may be rapid in children, and the agents should be used with caution in patients with renal impairment. In addition, PPA increases caffeine plasma levels and decreases theophylline clearance. Reduced metabolism of PE occurs with concurrent administration of monoamine oxidase inhibitors. No direct relationship between nasal decongestant effect and plasma concentration has been established.

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“…The requirement of rigorous control of PE concentration in pharmaceutical industry and also biological samples had led to the development of a variety of determination methods such as liquid and gas chromatography [4][5][6][7], spectrophotometry [8,9], spectrofluorimetry [10,11] and electrochemistry [12][13][14]. However, most of these methods are either time-consuming or require expensive and sophisticated instruments, well controlled experimental conditions and some sample pretreatments.…”

Section: Introductionmentioning

confidence: 99%

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

Soleymanpour

Abdifar

Bani³

2011

Electroanalysis

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The construction and performance characteristics of a coated graphite phenylephrine-selective electrode based on incorporation of the ion-association complex of phenylephrine-tetraphenylborate in plasticized PVC matrix was studied. The electrode exhibited a Nernstian slope of 59.0 mV/decade to phenylephrine over a wide concentration range from 3.0 10 À6 to 5.6 10 À2 M with a low detection limit of 1.5 10 À6 M. The proposed electrode manifested advantages of fast response, long life time and, most important, good selectivities for phenylephrine relative to a wide variety of common foreign inorganic cations, anions and also organic species. The electrode was successfully applied to determine phenylephrine in adult cold tablets, phenylephrine eye-drops and also blood serum samples. The inclusion complex formation between a-and b-cyclodextrine and phenylephrine was studied potentiometrically by the proposed electrode.

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GLC Determination of Phenylephrine Hydrochloride in Human Plasma

Cited by 18 publications

References 16 publications

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

Pharmacokinetics of Oral Decongestants

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

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