Determination of phenolic compounds, antioxidant and anticancer activity of
            <i>Chrozophora tinctoria</i>
            accessions collected from different regions of Iran

Golkar, Pooran; Taghizadeh, Marzieh; Jalali, Seyed Amir Hossein

doi:10.1111/jfbc.13036

Cited by 12 publications

(14 citation statements)

References 48 publications

(97 reference statements)

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“…There are many reports of the effects of phenolic compounds on cancer cell lines [ 52 , 53 , 54 ]. Unfortunately, the present study did not show any changes in the cancer cell metabolism after the exposure to the experimental concentrations of extracts from the control and elicited lovage ( Figures S1–S15 ).…”

Section: Discussionmentioning

confidence: 99%

In vitro Antioxidant, Anti-inflammatory, Anti-metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [Levisticum officinale Koch] Elicited with Jasmonic Acid and Yeast Extract

et al. 2020

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Lovage seedlings were elicited with jasmonic acid (JA) and yeast extract (YE) to induce the synthesis of biologically active compounds. A simulated digestion process was carried out to determine the potential bioavailability of phenolic acids. Buffer extracts were prepared for comparison. The ability to neutralize ABTS radicals was higher in all samples after the in vitro digestion, compared to that in the buffer extracts. However, the elicitation resulted in a significant increase only in the value of the reduction power of the potentially bioavailable fraction of phenolic acids. The effect of the elicitation on the activity of the potentially bioavailable fraction of phenolic acids towards the enzymes involved in the pathogenesis of the metabolic syndrome, i.e., ACE, lipase, amylase, and glucosidase, was analyzed as well. The in vitro digestion caused a significant increase in the ability to inhibit the activity of these enzymes; moreover, the inhibitory activity against alpha-amylase was revealed only after the digestion process. The potential anti-inflammatory effect of the analyzed extracts was defined as the ability to inhibit key pro-inflammatory enzymes, i.e., lipoxygenase and cyclooxygenase 2. The buffer extracts from the YE-elicited lovage inhibited the LOX and COX-2 activity more effectively than the extracts from the control plants. A significant increase in the anti-inflammatory and antimicrobial properties was noted after the simulated digestion.

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Section: Discussionmentioning

confidence: 99%

In vitro Antioxidant, Anti-inflammatory, Anti-metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [Levisticum officinale Koch] Elicited with Jasmonic Acid and Yeast Extract

et al. 2020

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“…Total flavonol (TFL) content was estimated as described in Golkar et al (2019) and absorbance was measured at 445 nm using the standard curve of quercetin for calibration. Finally, total flavonol content was reported as quercetin equivalent (QE) in mg per fresh leaf weight (mg QEg −1 FW).…”

Section: Total Flavonoid (Tfd) and Total Flavonol (Tfl) Contentsmentioning

confidence: 99%

“…Safflower (Carthamus tinctorius L.) is an oily crop with a long history of food, industrial, cosmetic, ornamental, and medicinal applications (Golkar and Karimi 2019;Hussain et al 2016). It is cultivated as a main crop in many (semi-) arid regions of the world with extremely low irrigation or agricultural potentials (Golkar and Karimi 2019). The total safflower seed yields in the world and in Iran are reportedly 9033 (hg ha −1 ) and 12,896 (hg ha −1 ), respectively (FAOSTAT 2016).…”

Section: Introductionmentioning

confidence: 99%

Safflower’s (Carthamus tinctorius L.) physio-biochemical mechanisms to improve its drought tolerance

et al. 2021

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Drought is a main stressor affecting plant production worldwide. Safflower (Carthamus tinctorius L.) is known to exploit biochemical strategies to tolerate drought stress. However, the little so far known about these strategies does not guarantee safflower yield stability in future. To fill the gap, changes in the biochemical traits and antioxidant activities of safflower were monitored using 100 genotypes under the two non-stress and drought-stress field conditions in two subsequent years (2017 and 2018). While drought stress was observed to give rise to reversible increases in total phenolics (TPC), total flavonoids (TFD), total flavonols (TFL), total anthocyanin (Ant), proline, malondialdehyde (MDA), and antioxidant activity, it decreased total chlorophyll (ChlT) and total carotenoid (Car) contents in safflower. Under drought stress, the highest values for TPC (21.55 16.07 mg GAEg −1 fresh weight [FW]), Car (0.08 mg g −1 FW), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) activity (98%) were measured in G 16 , averaged over the two study years. Also the highest values for TFD (5.17 mg QEg −1 FW), TFL (1.99 mg QEg −1 FW), Ant (234.1 µmol g −1 FW), ChlT (0.67 mg g −1 FW), and proline (851 μmol g −1 FW) were recorded for G 80 , G 60 , G 23 , G 62 , and G 33 . The least MDA content (2.8 µmol g −1 FW) was denoted to G 91 under drought stress. The results of both principal component and correlation analyses demonstrated the effective role of total flavonoids in safflower drought tolerance. The high genetic variance was seen to result in the high heritability of biochemical traits under drought stress, thereby improving drought tolerance in safflower cultivated in drought prone regions. The significant genetic variations in all the biochemical traits indicated that these traits, especially TPC and TFD, could be used as screening criteria for genotypic selection in arid climates.

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“…The phytochemical products of D. kotschyi cells were identi ed as apigenin, carvacrol, naringin, quercetin, rosmarinic acid, rutin, and thymol. The metabolism and accumulation of these phytochemical compounds can signi cantly be affected by different genetic and environmental factors (Golkar et al 2019a). These metabolites signi cantly changed in cells and culture media of the elicited samples (Tables 1 and 2).…”

Section: Effect Of the Smf And Mnps On The Phytochemical Compoundsmentioning

confidence: 99%

Modification of phytochemical production and antioxidant activity of Dracocephalum kotschyi cells by exposure to static magnetic field and magnetite nanoparticles

Taghizadeh

Nasibi

Kalantari

et al. 2021

Plant Cell Tiss Organ Cult

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Dracocephlum kotschyi Boiss is a genus in Lamiaceae family and a medicinal herb native to Iran. The cell suspension cultures were treated by static magnetic eld (SMF) and Fe 3 O 4 magnetite nanoparticles (MNP) to understand the production yield of secondary metabolites. The treatment procedure was done by cultivating the cells either with 100 ppm MNP, SMFs, or simultaneous exposure to both MNP and SMFs. The SMF at 30 mT was uniformly applied to the cells either for 3 or 4 days with a 3 h per day or a 5 h per day intervals, respectively. The contents of phenolics and phytochemicals were then examined by high performance liquid chromatography and UV-Vis spectrophotometer. These treatments imposed oxidative stress and induced polyphenol oxidase and phenylalanine ammonia lyase, accompanied by enhanced production of phenolics, anthocyanins, avonoids, and lignin. The highest membrane embrittlement and elicitation was found upon simultaneous application of the MNPs and SMFs, followed by the MNP and SMFs. The contents of naringin, rosmarinic acid, quercetin, thymol, carvacrol, apigenin, and rutin increased in the intracellular biomass of all treated cells and extracellular culture media. These ndings propose the potential of these elicitors in simultaneous production and secretion of these phytochemicals into culture media.

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Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

Cited by 12 publications

References 48 publications

In vitro Antioxidant, Anti-inflammatory, Anti-metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [Levisticum officinale Koch] Elicited with Jasmonic Acid and Yeast Extract

In vitro Antioxidant, Anti-inflammatory, Anti-metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [Levisticum officinale Koch] Elicited with Jasmonic Acid and Yeast Extract

Safflower’s (Carthamus tinctorius L.) physio-biochemical mechanisms to improve its drought tolerance

Modification of phytochemical production and antioxidant activity of Dracocephalum kotschyi cells by exposure to static magnetic field and magnetite nanoparticles

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