Determination of parabens in human milk and other food samples by capillary electrophoresis after dispersive liquid–liquid microextraction with back-extraction

Alshana, Usama; Ertaş, Nusret; Göǧer, Nilgün Günden

doi:10.1016/j.foodchem.2015.02.074

Cited by 76 publications

(27 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, these additives can be obtained from nature or manufactured by the chemical industry. The main food additives analyzed by CE in the period covered by this review (2013–2015) were sweeteners , preservatives , and colorants .…”

Section: Food Additivesmentioning

confidence: 99%

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

et al. 2015

View full text Add to dashboard Cite

This review work presents and discusses the main applications of capillary electromigration methods in food analysis and Foodomics. Papers that were published during the period February 2013-February 2015 are included following the previous review by Garcia-Cañas et al. (Electrophoresis, 2014, 35, 147-169). Analysis by CE of a large variety of food-related molecules with different chemical properties, including amino acids, hazardous amines, peptides, proteins, phenols, polyphenols, lipids, carbohydrates, DNAs, vitamins, toxins, contaminants, pesticides, residues, food additives, as well as small organic and inorganic compounds. This work includes recent results on food quality and safety, nutritional value, storage, bioactivity, as well as applications of CE for monitoring food processing. The use, among other CE developments, of microchips, CE-MS, and chiral CE in food analysis and Foodomics is also discussed.

show abstract

Section: Food Additivesmentioning

confidence: 99%

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The salt concentration seems to decrease the solubility of acetonitrile in water phase impairing the cloudy state. 30 Furthermore, the residual sodium might provide ion suppression decreasing the analytical signal in MS/MS. 17 Thus, no addition of NaCl was selected.…”

Section: Resultsmentioning

confidence: 99%

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Grecco¹,

Souza²,

Acquaro³

et al. 2018

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

A reliable method was developed and validated based on dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to determine simultaneously methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB) in breast milk samples. A central composite design 2 4 with four independent variables and five levels of variance was used to optimize the DLLME conditions. The DLLME/UHPLC-MS/MS method was linear from 5 (lower limit of quantification, LLOQ) to 100 ng mL -1 (upper limit of quantification, ULOQ). The inter-assay and intra-assay precision values presented coefficients of variation (CVs) lower than 15%, and the relative standard error of the inter-and intra-assay accuracy values was lower than 10.4%. The DLLME/UHPLC-MS/MS method was successfully applied to determine parabens in human milk samples obtained from sixteen volunteer lactating mothers.

show abstract

“…[1][2][3] When parabens are present in high concentrations in the dermis, they may accumulate in the human body tissues in a similar way to other lipophilic compounds, which are bioaccumulative, or they may induce allergic dermatitis in sensitive individuals. 3,4 Although the use of parabens is regulated, traces concentrations of unhydrolyzed parabens have been determined in different biological samples, including plasma, 5 breast milk, [6][7][8][9] ovarian tissues, 10 urine, 4,7,[11][12][13][14] and serum 4,7,13,15 by chromatographic or electrophoresis techniques. Biological samples may not be introduced in their nature state in chromatographic systems, due to their endogenous compounds, mainly the proteins that can: (i) suppress the ionization of analytes, during the ionization process (liquid chromatography-mass spectrometry (LC-MS) analysis); (ii) co-elute with analytes, during the chromatographic separation; or (iii) adsorb irreversibly in analytical column.…”

Section: Introductionmentioning

confidence: 99%

“…Biological samples may not be introduced in their nature state in chromatographic systems, due to their endogenous compounds, mainly the proteins that can: (i) suppress the ionization of analytes, during the ionization process (liquid chromatography-mass spectrometry (LC-MS) analysis); (ii) co-elute with analytes, during the chromatographic separation; or (iii) adsorb irreversibly in analytical column. Therefore, several sample preparation techniques, including protein precipitation, 16 solid phase extraction (SPE), 4,5,11,13 stir-membrane solid-liquid-liquid microextraction (SM-SLLME), 9 dispersive liquid-liquid microextraction (DLLME), 8,15 and microextraction by packed sorbent (MEPS), 12 have been used in combination with chromatographic or electrophoresis techniques to determine parabens in biological samples.…”

Section: Introductionmentioning

confidence: 99%

Development of Molecularly Imprinted Polymers for Solid Phase Extraction of Parabens in Plasma Samples and Analysis by UHPLC-MS/MS

Roldão

Melo

Miranda

et al. 2016

Journal of the Brazilian Chemical Society

View full text Add to dashboard Cite

Two molecularly imprinted polymers (MIPs) were synthesized, by sol-gel and radical polymerization procedures. These MIPs were evaluated as selective stationary phases for miniaturized solid phase extraction (MISPE) to determine parabens in plasma samples by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Selective cavities of the MIPs, based on molecular recognition (hydrogen bonds), were revealed after removal of the template (benzylparaben). Both MIPs were characterized by scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR). MIP prepared by radical process presented higher selective binding capacity for the target parabens than MIP prepared by sol-gel. Several variables that influence MISPE performance, including sample pH, sorbent washing, elution solvent, and elution solvent volume were also evaluated. According to the analytical validation parameters, the MISPE/UHPLC-MS/MS method is suitable for the analysis of parabens in plasma samples. The effectiveness of this method was demonstrated through the analyses of the umbilical plasma samples from postpartum women.

show abstract

Determination of parabens in human milk and other food samples by capillary electrophoresis after dispersive liquid–liquid microextraction with back-extraction

Cited by 76 publications

References 27 publications

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Development of Molecularly Imprinted Polymers for Solid Phase Extraction of Parabens in Plasma Samples and Analysis by UHPLC-MS/MS

Contact Info

Product

Resources

About