Determination of para-Chloroaniline and Reactive Oxygen Species in Chlorhexidine and Chlorhexidine Associated with Calcium Hydroxide

Barbin, Luiz Eduardo; Saquy, Paulo César; Guedes, Débora Fernandes Costa; Sousa‐Neto, Manoel Damião; Estrela, Carlos; Pécora, Jesus Djalma

doi:10.1016/j.joen.2008.08.032

Cited by 52 publications

(60 citation statements)

References 27 publications

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“…21 However, studies suggest that chlorhexidine in high concentrations, as that used in this study, poses a potential systemic risk by producing reactive oxygen species (ROS), causing oxidative damage to deoxyribonucleic acid (DNA), and the release of para-chloroaniline, a cytotoxic agent with carcinogenic potential in humans. 22,23 Although Nebacetin ® ointment and Maxitrol ® ointment are not used in dental treatment, they have already established antimicrobial power in their respective uses. Maxitrol ® ophthalmic ointment has a composition similar to that of Rifocort ® , insofar as it is composed of associations of corticosteroids (Dexamethasone) and antibiotics (Neomycin Sulfate and Polymyxin B Sulfate), and is used in ocular inflammatory conditions from bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of different filling pastes for deciduous tooth treatment

et al. 2014

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Guedes-Pinto paste is the filling material most employed in Brazil for endodontic treatment of deciduous teeth; however, the Rifocort ® ointment has been removed. Thus, the aim of this study was to investigate the antimicrobial potential of filling pastes, by proposing three new pharmacological associations to replace Rifocort ® ointment with drugs of already established antimicrobial power: Nebacetin ® ointment, 2% Chlorhexidine Gluconate gel, and Maxitrol ® ointment. A paste composed of Iodoform, Rifocort ® ointment and Camphorated Paramonochlorophenol (CPC) was employed as the gold standard (G1). The other associations were: Iodoform, Nebacetin ® ointment and CPC (G2); Iodoform, 2% Chlorhexidine Digluconate gel and CPC (G3); Iodoform, Maxitrol ® ointment and CPC (G4). The associations were tested for Staphylococcus aureus (S. aureus), Streptococcus mutans (S. mutans), Streptococcus oralis (S. oralis), Enterococcus faecalis (E. faecalis), Escherichia coli (E. coli), and Bacillus subtilis (B. subtilis),using the methods of dilution on solid medium -orifice agar -and broth dilution. The results were tested using statistical analysis ANOVA and Kruskal-Wallis. They showed that all the pastes had a bacteriostatic effect on all the microorganisms, without any statistically significant difference, compared with G1. S. aureus was statistically significant (multiple comparison test of Tukey), insofar as G2 and G3 presented the worst and the best performance, respectively. All associations were bactericidal for E. coli, S. aureus, S. mutans and S. oralis. Only G3 and G4 were bactericidal for E. faecalis, whereas no product was bactericidal for B. subtilis. Thus, the tested pastes have antimicrobial potential and have proved acceptable for endodontic treatment of primary teeth.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of different filling pastes for deciduous tooth treatment

et al. 2014

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“…4 The use of intracanal medication containing calcium hydroxide in its composition increases the chances of scarring. 9 In addition to maintaining high pH, it has antimicrobial activity and inhibitory action of inflammatory root resorption.…”

Section: Introductionmentioning

confidence: 99%

External root resorption: diagnosis and treatment. clinical case report

Santos¹,

Mateo-Castillo²,

Nishiyama³

et al. 2018

JDHODT

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Root resorptions are pathologies usually diagnosed by X-Ray rotine evaluation. They can be classified as internal, when root canal is involved and external, when periodontal ligament is involved. External root resorptions are processes in which the loss of cementoblasts occurs causing the mineralized surfaces to be susceptible to the action of clastic cells. The treatment of root resorption is basically root and / or periodontal endodontic treatment, depending on the location and extent of the reabsorption. When it attacks the cervical region, radical endodontic treatment can usually be associated with surgical complementation. The present study aims to analyze the efficacy obtained with the treatment of external cervical radicular resorption of an individual attended at the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC / USP), in which periodontal treatment and clinical and radiographic followup were performed. This study presents a more conservative alternative treatment of external root resorption, with preservation of the pulp vitality of the dental element accompanied by the apparent stabilization of the resorptive process without the need for radical endodontic treatment.

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“…O hidróxido de cálcio é mundialmente considerado a medicação intracanal de escolha da endodontia. Sua ação depende basicamente da elevação do pH e o tempo torna-se primordial para que todo o meio do sistema de canais se torne básico o suficiente para promover ou manter a desinfecção alcançada durante as fases anteriores (Haapasalo et al, 2000;Almyroudi et al, 2002;Erdemir et al, 2004;Ballal et al, 2007;Krithikadatta et al, 2007;Manzur et al, 2007;Neelakantan et al, 2007;Wang et al, 2007;Barbin et al, 2008).…”

Section: Discussionunclassified

“…A CLX quando aquecida a 37 o C, temperatura corporal, ou a 45 o C, temperatura atingida quando se utiliza a irrigação ultrassônica passiva, sofre degradação apresentando como principal subproduto a PCA (Barbin et al, 2008;.…”

Section: Nacional De Toxicologia Da Agência De Proteção Ambiental (Epunclassified

“…Nessa técnica a amostra pode ser aquecida a Nesses trabalhos, a solução de CLX é autoclavada a 121 o C antes de reagir com o NaOCl, o que bastaria para a degradação da CLX em PCA. Como a PCA é uma molécula bastante estável, sugere-se que ela não seria degradada pelo NaOCl durante o preparo da amostra NaOCl/CLX, sendo observada no resultado da análise química (Basrani et al, 2007;Barbin et al, 2008;Basrani et al, 2010;Sodhi et al, 2011).…”

Section: Nacional De Toxicologia Da Agência De Proteção Ambiental (Epunclassified

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Análise química do precipitado formado na reação entre hipoclorito de sódio e digluconato de clorexidina

Brum¹

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Determination of para-Chloroaniline and Reactive Oxygen Species in Chlorhexidine and Chlorhexidine Associated with Calcium Hydroxide

Cited by 52 publications

References 27 publications

Antimicrobial activity of different filling pastes for deciduous tooth treatment

Antimicrobial activity of different filling pastes for deciduous tooth treatment

External root resorption: diagnosis and treatment. clinical case report

Análise química do precipitado formado na reação entre hipoclorito de sódio e digluconato de clorexidina

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