Determination of Pantoprazole in Pharmaceutical Formulations and Human Plasma by Square‐Wave Voltammetry

Abstract

A simple, sensitive, and selective square-wave voltammetric method was developed for the determination of pantoprazole. The influence of the nature of the supporting electrolyte solution, pH, modulation amplitude, frequency, and scan increment was examined by square-wave voltammetric method for pantoprazole. The best results were obtained in Britton-Robinson buffer of pH 5.0. The peak currents were measured with hanging mercury drop electrode at 2987 mV vs. Ag/ AgCI. The calibration curve for pantoprazole was found as linear at a concentration range from 0.15 to 25.23 mg mL 21 . The limit of detection and the limit of quantification of pantoprazole were 0.048 mg mL 21 and 0.15 mg mL 21 , respectively. The validation parameters of the proposed method were evaluated. The method was applied to the pharmaceutical formulation and to both spiked plasma and the plasma of patients orally administered pantoprazole. A spectrophotometric method reported in the literature was utilized as a comparison method. There were no significant differences between the results obtained by two methods.

Anodized Edge-plane pyrolytic graphite for electroanalysis of pantoprazole in tablet dosage forms and human urine samples

“…Compared with the hanging mercury drop (HMD) electrode, the anodized EPPG electrode shows lower performance in terms of sensitivity and detection limit but in addition to toxicity related problems, the HMD electrode shows a very narrow range of linear concentration. 26,27 RESEARCH ARTICLE The results in Table 2 also demonstrate that the anodized EPPG has a better response characteristics compared with the other carbon-based electrodes (CP 23 and GC 24,25 ). Compared with the chemically modified electrodes, [28][29][30][31][32] the EPPG electrode exhibited a higher analytical performance especially in terms of detection limit and sensitivity (Table 2).…”

“…So far, direct electro-oxidation of pantoprazole at the carbonbased electrodes has been reported based on carbon paste (CP) 23 and glassy carbon (GC) 24,25 electrodes. Except carbonbased electrodes, hanging mercury drop (HMD) 26,27 and chemi-cally modified electrodes [28][29][30][31][32] have been also used for pantoprazole electroanalysis. At the first part of this paper, electrooxidation of pantoprazole at the CP, GC, edge-plane pyrolytic graphite (EPPG), basal-plane pyrolytic graphite (BPPG), and some nanostructured carbon-based materials such as CNTmodified GC, graphene oxide (GO)-modified GC, and carbon black (CB)-modified GC electrodes are comparatively evaluated .…”

Lower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitus

“…13 An electrochemical analyzer (BAS 100 B/W, Bioanalytical Systems, West Lafayette, IN, USA) was used for all experiments. Silver/silver chloride with saturated potassium chloride was used for the reference electrode, while a platinum wire was used as the auxiliary electrode.…”

“…The optimum parameters were: initial potential, −200 mV; square wave frequency (f), 50 Hz; square wave amplitude (ESW), 35 mV; scan increment (ΔE), 7 mV. 13 …”

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

“…A well defined irreversible oxidation peak current was obtained at 1.00 V. The detection limit was found 6.2 10 -5 M for albendazole. Pharmaceutical dosage forms, plasma [76] Abacavir has an antiretroviral activity against human immunodeficiency virus (HIV) and is oxidizable at the glassy carbon electrode (GCE). Uslu and Ozkan [37] developed SWV and DPV methods for abacavir in pharmaceuticals and biological fluids.…”