Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure

Avcı, Emre; Çakır, Erdinç; Cevher, Şule Çoşkun; Yaman, Halıl; Ağıllı, Mehmet; Bilgi, Cumhur

doi:10.3109/0886022x.2014.890841

Cited by 24 publications

(14 citation statements)

References 40 publications

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“…They showed that serum 8-OHdG was negatively related with estimated GFR and positively was associated with inflammatory markers such as hsCRP, IL-6, TNF, endothelial function marker (VCAM-1) and iron status (ferritin) (14). Avci et al concluded that albumin and hemoglobin had an inverse relation with 8-OHdG which is in agreement with our finding (14,29).…”

Section: Discussionsupporting

confidence: 92%

“…One study has shown the increase in the levels of 8-OHdG (marker of DNA damage) and malondialdehyde (marker of lipid damage) after HD in diabetic nephropathy (DN) and non-DN groups but decrease was observed in the asymmetric dimethylarginine (marker of endothelial damage) levels. This finding needs more attention (29). One study showed that measurement of 8-OHdG in the plasma rather than tissue of diabetic rats is a more useful biomarker of oxidative DNA damage (38).…”

Section: Limitationsmentioning

confidence: 99%

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Association of 8-hydroxy-2’-deoxyguanosine with various demographic and biochemical parameter in a group of hemodialysis patients

Goli

Nasri

2020

J Prev Epidemiol

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Introduction: Hemodialysis (HD) patients have elevated markers of oxidative stress which is contributed to increased mortality. Objectives: The aim of this study was to determine the association of 8-hydroxy-2’-deoxyguanosine (8- OHdG) as a marker of oxidative stress with various demographic and biochemical parameters in HD patients. Patients and Methods: Eighty-five HD patients (58 men and 27 women; mean ± SD of age was 62.8 ± 13.76 years) who were under HD therapy for at least six months and did not have a systemic infection were enrolled in the study. Serum 8-OHDG was measured by ELISA (enzyme-linked immunosorbent assay) method. Additionally levels of vitamin D, magnesium, and intact parathyroid hormone (PTH) were measured with standard kits. Other clinical and biochemical variables were gathered from patients’ files. Results: The result showed no significant correlation between serum levels of 8-OHDG with measured biochemical and demographic parameters. However, in HD patients with diabetes and hypertension (or combined), a significant reverse correlation between serum albumin and 8-OHdG was detected. Conclusion: In the age group under 40 years, we found a positive and significant correlation between albumin and 8-OHdG. This finding requires further investigation to determine relationship between serum 8-OHdG levels and serum albumin types as reduced and oxidized forms.

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Section: Discussionsupporting

confidence: 92%

Section: Limitationsmentioning

confidence: 99%

Association of 8-hydroxy-2’-deoxyguanosine with various demographic and biochemical parameter in a group of hemodialysis patients

Goli

Nasri

2020

J Prev Epidemiol

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“…[22][23][24][25] The current study assessed lipid peroxidation, antioxidant defenses and trace elements in CRF patients compared with healthy controls. Trace elements such as Se, Zn and Cu are required during several steps in the intermediary metabolism of mammalian cells.…”

Section: Discussionmentioning

confidence: 99%

The association of oxidant–antioxidant status in patients with chronic renal failure

Aziz¹,

Majeed²,

Diab

et al. 2015

Renal Failure

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Oxidative stress has been linked to disease progression, including chronic renal failure (CRF). The aim of the present study was to determine malondialdehyde (MDA) as a sign of lipid peroxidation, and to investigate the association between antioxidant activities and three trace elements, in 49 patients with CRF. The erythrocyte and plasma trace elements [selenium (Se), zinc (Zn), and copper (Cu)] and antioxidant defense levels were determined: glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), vitamins E and C. The obtained values were compared with 42 age-and sex-matched healthy controls. There were significantly lower mean values of plasma Se, GPx, vitamins E and C, erythrocyte Se, SOD and CAT levels in the patient group compared to the control group (p50.001). Plasma MDA showed a significant increase in all CRF patients in comparison with controls. No significant difference was found in plasma Cu, Zn, and erythrocyte GPx, Cu and Zn levels between patient and control groups. These findings indicate oxidative stress is present in patients of CRF, and may serve to establish a simple protocol for evaluation of renal function.

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“…Low molecular weight uremic toxins are water-soluble compounds with a molecular weight below 0.5 kDa, and consequently are easily removed by dialysis, and do not exert harmful effects on the body (26,27). The most important uremic toxins classified as purine derivatives are: Products resulted from the degradation of purines (adenosine, inosine, xanthine, guanosine, hypoxanthine, guanine, UA), products of guanosine triphosphate catabolism (neopteri n) and oxidative DNA base damage product (8-hydroxy-deoxy-guanosine) (28)(29)(30). The metabolic pathways of purine catabolism imply several phases (31).…”

Section: Introductionmentioning

confidence: 99%

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P= 0.036, r=-0.384 and P= 0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.

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Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure

Cited by 24 publications

References 40 publications

Association of 8-hydroxy-2’-deoxyguanosine with various demographic and biochemical parameter in a group of hemodialysis patients

Association of 8-hydroxy-2’-deoxyguanosine with various demographic and biochemical parameter in a group of hemodialysis patients

The association of oxidant–antioxidant status in patients with chronic renal failure

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

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