Determination of nitrofurantoin drug in pharmaceutical formulation and biological fluids by square-wave cathodic adsorptive stripping voltammetry

Hammam, Essam

doi:10.1016/s0731-7085(02)00344-8

Cited by 42 publications

(20 citation statements)

References 25 publications

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“…Hamam [103] has described the fully validated, sensitive, and reproducible developed procedure for determination of the nitrofurantoin in bulk form, pharmaceutical formulation, human serum and human urine using, square-wave cathodic adsorptive stripping voltammetry. The cyclic voltammogram of the nitrofurantoin in Britton-Robinson buffers (pH 2 -11) exhibited a single well-defined cathodic peak at the hanging mercury drop electrode, that due to the reduction of its nitro group to the amine stage.…”

Section: Examples Of Swv Analysis In Stripping Modementioning

confidence: 99%

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

Dogan‐Topal¹,

Özkan²,

Uslu

2010

TOCBMJ

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Compared to other voltammetric techniques a square wave voltammetry (SWV), which is presented in this minireview, has a several advantages such as high speed, increased analytical sensitivity and relative insensitivity to the presence of dissolved oxygen. Also it is an electrochemical technique used in analytical applications and fundamental studies of electrode mechanism. This paper delivers both the underlying theory and the practical guidance needed to apply square wave techniques and also provides a wide collection of data for the description of diverse tendencies that characterize several electrochemical reactions analyzed by SWV. This review summarizes some of the recent developments and application of direct and stripping SWV for drug compounds in their dosage forms and biological samples as reported in the period from 1997 till 2010 year.

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Section: Examples Of Swv Analysis In Stripping Modementioning

confidence: 99%

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

Dogan‐Topal¹,

Özkan²,

Uslu

2010

TOCBMJ

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“…Various advanced methods are available for its assay in dosage forms and in biological fluids [7][8][9][10][11][12][13][14][15][16][17][18][19] . These includes stripping voltammetry [7][8][9][10][11][12][13] , high performance liquid chromatography [14][15][16][17] , LC-MS 18,19 , Liquid-Liquid extraction 15,19 and flow injection analysis 20 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:The objective of the present work was to set up microcoulometric technique in the laboratory and estimate microgram level quantity of nitrofurantoin in the pharmaceutical tablets. A simple, sensitive, and reproducible manually operated microcoulometric technique has been successfully used for the estimation of nitrofurantoin in pharmaceutical tablets. A potentostat and coulometric cell was used in the technique. A coulometric cell was consist of mercury pool electrode, spiral silver electrode, and saturated calomel electrode. The accuracy of the current was 1µA and applied potential was 0.001 volt against SCE. Further, the prepared tablet solution of nitrofurantoinin ammonia buffer of pH 9.0 was estimated and statistical analysis of the data were carried out. Polarogram of the nitrofurantoin in ammonia buffer of pH 9.0, shows that six electrons are involved in the reduction of nitrofurantoin. The lowest limit of estimation of nitrofurantoin was 15ug. The reprodusability of estimation i.e. relative root mean square error(RMSE) was less than 2µg. The recovery was 100 ± 5%.

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“…It is used in the treatment of initial or recurrent urinary tract infections caused by susceptible organisms [2]. The drug is active against various gram-negative and some gram-positive bacteria, for instance: Escherichia coli, Enterococcus faecalis, Staphylococcus aureus or agalactiae, Enterobacter and Pseudomonas species [3,4].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Nitrofurantoin at a Mercury Meniscus Modified Silver Solid Amalgam Electrode

2014

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Electrochemical behavior of nitrofurantoin (NF) was studied by direct current voltammetry (DCV), differential pulse voltammetry (DPV), and cyclic voltammetry (CV) using a mercury meniscus modified silver solid amalgam electrode (m‐AgSAE). Voltammetric behavior of NF was studied in cathodic region of potentials in dependence on pH. pH 7.0 was selected as an optimal medium for the determination of NF by both DCV and DPV, with the optimal methanolwater volume ratio of 1 : 9. In order to reduce the negative influence of electrode passivation, the suitable regeneration potentials were found (0 mV and −900 mV). The optimal conditions were found for the determination of NF in concentration ranges from 6×10−6 mol L−1 to 1×10−4 mol L−1 using DCV technique, and from 2×10−7 mol L−1 to 1×10−4 mol L−1 using DPV technique, both in the medium of methanolBritton–Robinson buffer pH 7.0 (1 : 9). The attained limit of quantification (LOQ) of NF was 1.6×10−6 mol L−1 for DCV and 8.1×10−8 mol L−1 for DPV. The practical applicability of the newly developed DPV method was verified by direct determination of NF in model samples of drinking and river water, with LOQs 2.2×10−7 mol L−1 and 2.5×10−7 mol L−1, respectively.

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Determination of nitrofurantoin drug in pharmaceutical formulation and biological fluids by square-wave cathodic adsorptive stripping voltammetry

Cited by 42 publications

References 25 publications

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

Untitled

Voltammetric Determination of Nitrofurantoin at a Mercury Meniscus Modified Silver Solid Amalgam Electrode

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