Determination of neonicotinoid insecticides and their metabolites in honey bee and honey by liquid chromatography tandem mass spectrometry

Gbylik-Sikorska, Małgorzata; Śniegocki, Tomasz; Posyniak, Andrzej

doi:10.1016/j.jchromb.2015.03.016

Cited by 84 publications

(45 citation statements)

References 26 publications

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“…Recently, ion chromatography proved as an efficient and rapid alternative technique for separation of polar organic analytes apart from inorganic ions due to ionic nature and strong electrostatic force of attraction between polar/acidic analytes and ion exchange column bed. Besides, polymeric based columns have high stability in a wide pH range (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and are compatible with all solvents [31].…”

Section: Introductionmentioning

confidence: 99%

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

Nadeem

Zhang

et al. 2018

J of Separation Science

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A simple, cost-effective, sensitive, and quick method for the determination of nitenpyram and its metabolite 6-chloronicotinic acid in environmental samples was developed by coupling an ion chromatograph with a fluorescence detector and a post-column photochemical reactor. This developed analytical method involved a rapid sample extraction by modified and miniaturized quick, easy, cheap, effective, rugged, and safe method followed by isocratic ion chromatographic separation of nitenpyram and 6-chloronicotinic acid into an IonPac AS11-HC column protected by IonPac AG11A guard column by running 30 mM NaOH + 10% acetonitrile mobile phase. A homemade post-column photochemical reactor was also integrated with the ion chromatographic system for online transformation of both analytes into their respective highly fluorescent photoproduct in basic media without using an extra pump. The developed method was validated by following SANTE/11945/2015 guidelines on analytical quality control and validation procedures. The method showed a good linear response (r > 0.999), improved limit of detection (0.101-0.132 μg/L), minimum or no matrix effect, excellent recoveries (90.2-100.10%) and relative standard deviations were found to be ≤6.50%.

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Section: Introductionmentioning

confidence: 99%

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

Nadeem

Zhang

et al. 2018

J of Separation Science

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“…Honey samples are easy to obtain from a very broad range of geographical localities, thus enabling a worldwide analysis. Analytical protocols have been developed to analyze neonicotinoid concentrations in honey (23), and several studies have quantified the concentration of neonicotinoids in honey (24)(25)(26). However, the amount of data is limited, quantification thresholds vary among studies, and a global picture of neonicotinoid contamination in honey is lacking.…”

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confidence: 99%

A worldwide survey of neonicotinoids in honey

Mitchell

Mulhauser²,

Mulot

et al. 2017

Science

367

235

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Growing evidence for global pollinator decline is causing concern for biodiversity conservation and ecosystem services maintenance. Neonicotinoid pesticides have been identified or suspected as a key factor responsible for this decline. We assessed the global exposure of pollinators to neonicotinoids by analyzing 198 honey samples from across the world. We found at least one of five tested compounds (acetamiprid, clothianidin, imidacloprid, thiacloprid, and thiamethoxam) in 75% of all samples, 45% of samples contained two or more of these compounds, and 10% contained four or five. Our results confirm the exposure of bees to neonicotinoids in their food throughout the world. The coexistence of neonicotinoids and other pesticides may increase harm to pollinators. However, the concentrations detected are below the maximum residue level authorized for human consumption (average ± standard error for positive samples: 1.8 ± 0.56 nanograms per gram).

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“…To our best knowledge, no rapid method of analysis of up to 132 insecticides belonging to 29 chemical classes in honey samples, using QuEChERS/LC-MS/MS has been described in the literature. Works available in the literature describe methods that make it possible to determine individual groups of insecticides: benzoylurea (Wang et al 2016), neonicotinoids (Gbylik-Sikorska et al 2015;Jovanov et al 2013Jovanov et al , 2014, organochlorines (Zacharis et al 2012), pyrethroids (Li et al 2013), organophosphorus (Naggar et al 2015;Blasco et al 2004), or several groups of insecticides, but never so many. For instance, Paradis et al (2014) reported the simultaneous determination of 22 insecticides of three chemical classes in honey.…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatographic MS/MS Analysis of a Large Group of Insecticides in Honey by Modified QuEChERS

2018

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The analytical tool for analysis of pesticide residues in honey must still be improved. Therefore, a sensitive, selective, rapid, and reliable analytical method for the analysis of pesticide residue belonging to 29 different classes at very low concentration levels was developed. Over 130 insecticides were extracted from the honey matrix using different amounts of sample, concentrations of the extraction solvent, and cleanup sorbents. Acceptable extraction recoveries accounting for matrix effect were obtained using the cleanup sorbent combination chitosan/aluminum oxide/C8 (200/200/200 mg) and 1% FA in ACN. Determinations were made by liquid chromatography-tandem mass spectrometry (LC-MS/MS). For most compounds, the recoveries range from 70 to 120%, with relative standard deviations < 20%. Linear correlation coefficients (r2) were higher than 0.99 at concentration levels of 0.001-0.100 mg kg−1. A positive matrix effect was observed for up to 95% of organophosphates and 43% of pyrethroids and a negative effect for 37% of neonicotinoids. This work showed that the presented method is convenient and reliable for quick monitoring of insecticides in honey samples.

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Determination of neonicotinoid insecticides and their metabolites in honey bee and honey by liquid chromatography tandem mass spectrometry

Cited by 84 publications

References 26 publications

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

A worldwide survey of neonicotinoids in honey

Liquid Chromatographic MS/MS Analysis of a Large Group of Insecticides in Honey by Modified QuEChERS

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