Determination of mycotoxins by HPLC, LC-MS/MS and health risk assessment of the mycotoxins in bee products of Turkey

Keskin, Eda; Eyüpoğlu, Ozan Emre

doi:10.1016/j.foodchem.2022.134086

Cited by 35 publications

(15 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These methods are instrumental in identifying and quantifying toxins, heavy metals, antibiotic residues, and various other chemicals present in food, water, soil, and air. This approach provides a more comprehensive understanding of the chemical landscape, thereby aiding in early detection, precise assessment, and effective management of environmental and public health risks. − The proposed enhancements extend the surveillance systems beyond traditional biological markers, enabling a more detailed understanding of the environmental factors that contribute to disease emergence and spread.…”

Section: Factors Contributing To the Risk Of Infectious Diseasesmentioning

confidence: 99%

Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management

Singh,

Sharma,

Pal

et al. 2024

ACS Infect. Dis.

View full text Add to dashboard Cite

Recent pandemics, including the COVID-19 outbreak, have brought up growing concerns about transmission of zoonotic diseases from animals to humans. This highlights the requirement for a novel approach to discern and address the escalating health threats. The One Health paradigm has been developed as a responsive strategy to confront forthcoming outbreaks through early warning, highlighting the interconnectedness of humans, animals, and their environment. The system employs several innovative methods such as the use of advanced technology, global collaboration, and data-driven decision-making to come up with an extraordinary solution for improving worldwide disease responses. This Review deliberates environmental, animal, and human factors that influence disease risk, analyzes the challenges and advantages inherent in using the One Health surveillance system, and demonstrates how these can be empowered by Big Data and Artificial Intelligence. The Holistic One Health Surveillance Framework presented herein holds the potential to revolutionize our capacity to monitor, understand, and mitigate the impact of infectious diseases on global populations.

show abstract

Section: Factors Contributing To the Risk Of Infectious Diseasesmentioning

confidence: 99%

Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management

Singh,

Sharma,

Pal

et al. 2024

ACS Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Extensive literature supports the efficacy of MRM-LC-MS/MS techniques in detecting various mycotoxins in cereals with heightened sensitivity, particularly in positive ion mode, such as AFB 1 , AFB 2 , AFG 1 , AFG 2 , OTA, T-2, HT-2, and FB 1 . 4,11,12 Conversely, ZEN and DON typically yield optimal mass spectrometry signal intensity in negative ion mode. 37,38 To address this, the data in positive and negative mode were simultaneously captured to establish MRM parameters for ten mycotoxins.…”

Section: Optimization Of Mirm Parameters and Preparation Of Calibrati...mentioning

confidence: 99%

“…2,4,10 These techniques have emerged as the "gold standard" for multimycotoxin quantitative analysis. 11,12 Since mass spectrometry lacks inherent calibration, diverse calibration strategies have been developed to enhance accuracy and precision. 13 Consequently, in the pursuit of a dependable analytical approach, the creation of calibration curves stands out as a pivotal phase.…”

Section: Introductionmentioning

confidence: 99%

Integrating a Multiple Isotopologue Reaction-Monitoring Technique and LC-MS/MS for Quantitation of Small Molecules: Ten Mycotoxins in Cereals as an Example

Sun,

Li,

Tan

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Accurate quantification of mycotoxin in cereals is crucial for ensuring food safety and human health. However, the preparation of traditional multisample external calibration curves (MSCCs) is labor-intensive and error-prone. Here, a multiple isotopologue reaction-monitoring (MIRM)-LC-MS/MS method for accurate quantitation of ten major mycotoxins in cereals was successfully developed and validated, where a novel one-sample multipoint calibration curve (OSCC) strategy is used instead of MSCCs. The OSCC can be established by examining the correlation between the calculated theoretical isotopic abundances and the measured abundance across various MIRM channels. In comparison to the MSCC, the OSCC strategy exhibits outstanding performance including superior selectivity, accuracy (78.4−108.6%), and precision (<12.5%). Furthermore, the proposed OSCC-MIRM-LC-MS/MS method was successfully applied to investigate mycotoxin contamination in cereal samples in China. Considering the advantages of simplified workflows and improved throughput, the OSCC-MIRM-LC-MS/MS methodology holds great promise for accurately quantifying chemical contaminants in foods.

show abstract

“…However, to effectively enforce these measures, it is essential to develop reliable, accurate, sensitive, and cost‐effective analytical methods. Large‐scale instrumental assays used for the detection of mycotoxins, such as high‐performance liquid chromatography (HPLC) (Keskin & Eyupoglu, 2023), LC–tandem mass spectrometry (LC–MS/MS) (Guan et al., 2022), ultra‐HPLC (Zhu et al., 2015), and LC time‐of‐flight mass spectrometry (Wang et al., 2017) are commonly used as official standard methods for detection. They exhibit the advantages of providing accurate and reliable results, wide detection range, high sensitivity, and simultaneous detection of multiple mycotoxins, including modified mycotoxins (Birr et al., 2021; Yang et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

Improvement of the sensitivity of lateral flow systems for detecting mycotoxins: Up‐to‐date strategies and future perspectives

Li,

Jallow,

Nidiaye

et al. 2023

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Mycotoxins are dangerous human and animal health‐threatening secondary fungal metabolites that can be found in various food and agricultural products. Several countries have established regulations to restrict their presence in food and agricultural products destined for human and animal consumption. Consequently, the need to develop highly sensitive and smart detection systems was recognized worldwide. Lateral flow assay possesses the advantages of easy operation, rapidity, stability, accuracy, and specificity, and it plays an important role in the detection of mycotoxins. Nevertheless, strategies to comprehensively improve the sensitivity of lateral flow assay to mycotoxins in food have rarely been highlighted and discussed. In this article, a comprehensive overview was presented on the application of lateral flow assay in mycotoxin detection in food samples by highlighting the principle of lateral flow assay, presenting a detailed discussion on various analytical performance‐improvement strategies, such as the development of high‐affinity recognition reagents, immunogen immobilization methods, and signal amplification. Additionally, a detailed discussion on the various signal analyzers and interpretation approaches was provided. Finally, current hurdles and future perspectives on the application of lateral flow assay in the detection of mycotoxins were discussed.

show abstract

Determination of mycotoxins by HPLC, LC-MS/MS and health risk assessment of the mycotoxins in bee products of Turkey

Cited by 35 publications

References 26 publications

Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management

Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management

Integrating a Multiple Isotopologue Reaction-Monitoring Technique and LC-MS/MS for Quantitation of Small Molecules: Ten Mycotoxins in Cereals as an Example

Improvement of the sensitivity of lateral flow systems for detecting mycotoxins: Up‐to‐date strategies and future perspectives

Contact Info

Product

Resources

About