Determination of mifepristone levels in wild canid serum using liquid chromatography

Simultaneous determination of rivanol and mifepristone in human plasma by a HPLC-UV method with solid-phase extraction

“…However, to our best knowledge, no analytical method has been described in the literature which simultaneously determines these two analytes, even though several methods exist, which separately determine either rivanol [5][6][7][8][9][10][11] or mifepristone [12][13][14][15][16][17][18][19]. Obviously, it is discommodious to determine rivanol and mifepristone separately for each sample under two different HPLC conditions.…”

An HPLC method for the determination of ng mifepristone in human plasma

“…Various determining methods based on radioimmunoassay (RIA) [6,7], radioreceptorassay (RRA) [8,9] and high performance liquid chromatography (HPLC) [10][11][12] have been used to measure serum mifepristone levels. Due to the cross-reacting metabolites, the direct RIA and RRA methods were not specific for the parent mifepristone and its metabolites.…”

“…Another one reported by Chang-hai et al [11] was a liquid-liquid extraction with UV detection, with LOD 36 ng/ml and LOQ 240 ng/ml. Recent one described by Stith and Hussian [12] was a solid-phase extraction with UV detection, with the assay linear in the range of 10-1000 ng/ml. No LOD and LOQ were reported, and the internal standard RTI-3021-003 was difficult to acquire.…”

Simultaneous determination of mifepristone and monodemethyl‐mifepristone in human plasma by liquid chromatography–tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study

“…The retention times for mifepristone, monodemethyl-mifepristone and the IS were 2.20, 1.82 and 3.37 min, respectively. The method had a very short total run time (4.5 min) for simultaneous determination of RU 486 and RU 42633 compared with the reported HPLC methods (Heikinheimo et al, 1986;Heikinheimo, 1989;He et al, 1989;Shi et al, 1993;Stith and Hussain, 2003;Guo et al, 2006Guo et al, , 2007a.…”

“…Similar solid phase extraction procedures have been reported to extract the analytes from bio-matrices (Stith and Hussain, 2003;Guo et al, 2006Guo et al, , 2007a. The SPE procedure described by Guo et al was tried during our method development.…”