Tailor-welded blanks of interstitial free steel are commonly used in complex automotive skin panels. The presence of weld zone, difference in thickness and high anisotropic behaviour affect forming behaviour of tailor-welded blanks significantly. Therefore, incorporation of anisotropy of the sheets and properties of the weld zone in finite element simulations is very important for accurate prediction of springback in bending of tailor-welded blanks. In this study, experimental and finite element simulations of V-bending were carried out on tailor-welded blanks of three thickness combinations, prepared by Nd-YAG laser welding of interstitial free steel sheets of thicknesses 0.8, 1.2 and 1.5 mm. The orientation of the weld line in longitudinally welded blanks was kept at 0°, 45°and 90°with respect to the rolling direction to study the effects of anisotropy on springback in V-bending. The tensile properties of the weld zone in different thickness combinations were determined and incorporated in finite element simulations for prediction of springback. It was observed that springback results were mainly governed by the springback behaviour of the thicker sheet in a particular thickness combination. Weld zone properties affect the springback of tailor-welded blanks more significantly than the anisotropy of the sheets. Accuracy of predicted values of springback in simulations increased when the properties of the weld zone were incorporated in the material model.