Determination of malondialdehyde, Uric Acid, Bilirubin And Total Antioxidant Status, in Children Under 5 Years Suffering From Malaria in Osogbo, Nigeria

Olisekodiaka, Japhet M.; Onuegbu, Anaelechi J.; Igbeneghu, C.; Nwagbo, N.; Amah, Ubuo K.; Okwara, John E.

doi:10.9790/0853-1604086569

Cited by 4 publications

(6 citation statements)

References 23 publications

(21 reference statements)

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“…Furthermore, several studies emphasized an intensified theme revolving around even higher UA levels in severe malaria cases compared to non-severe ones 17 , 19 , 30 , 33 , 34 , 41 . An interesting narrative thread found in the four studies posits a direct relationship between the intensity of malaria parasitemia and rising UA levels 17 , 31 , 34 , 39 . However, contrasting themes were evident in studies by Aqeel et al 29 and Idonije et al 4 , where narratives did not underscore a significant difference in UA levels between the two groups (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the initial databases, we also reviewed Google Scholar and reference lists to broaden eligibility criteria. Four studies were identified from Google Scholar 36 – 39 , and three were identified in reference lists 40 – 42 , resulting in a final total of 19 studies being included in the review 4 , 6 , 17 , 19 , 20 , 29 – 42 (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“… 4 , and Thurnham et al 35 had an unclear status regarding the inclusion criteria and addressing confounding factors. Among the case–control studies, Ebrahim et al 37 , Hatim et al 40 , and Olisekodiaka et al 39 lacked identification of confounding factors and strategies to address them. In the cohort studies, Chandrashekhar et al 33 and Lopera-Mesa et al 17 lacked identification of confounding factors, strategies to address them, and details on follow-up time.…”

Section: Resultsmentioning

confidence: 99%

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Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis

Kuraeiad,

Kotepui,

Masangkay

et al. 2023

Sci Rep

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Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria. A comprehensive literature search was carried out across databases such as Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify relevant studies for inclusion. The methodological quality of the included studies was evaluated independently by two reviewers using the JBI critical appraisal tool for observational studies. A meta-analysis was performed to calculate the pooled effect sizes, expressed as Hedges' g, with 95% confidence intervals (CIs). The Hedges' g was pooled using the random-effects model. An initial search yielding a total of 1122 articles, and a final total of 19 studies being included in the review. Elevated UA levels were observed more prominently in malaria patients, especially those with severe manifestations, when compared to uninfected controls. The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from malaria as compared to uninfected controls (P < 0.01, Hedges’s g = 1.40, 95% CI 0.84–1.95, I2 = 95.81, 16 studies). The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from severe malaria as compared to non-severe malaria (P < 0.01, Hedges’s g = 3.45, 95% CI 1.06–5.83, I2 = 98.73, 6 studies). In summary, these findings provide valuable insights into the potential use of UA as a biomarker for malaria infection and determination of its severity. Further research is needed to validate these findings and to explore the underlying mechanisms that contribute to the elevation of UA levels during malaria infection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis

Kuraeiad,

Kotepui,

Masangkay

et al. 2023

Sci Rep

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“…All 11 case–control studies met most quality assessment criteria, including comparable groups, appropriate matching, consistent criteria for case identification, reliable exposure measurement, and valid outcome assessment [ 15 , 26 – 29 , 32 , 33 , 37 , 38 , 40 , 41 ] (Table S3). Some studies addressed confounding factors and provided strategies to deal with them [ 27 – 29 , 40 , 41 ], while others did not. A few studies had exposure periods long enough to be meaningful [ 15 , 37 , 38 ], but not all.…”

Section: Resultsmentioning

confidence: 99%

“…This trend was observed in several studies [ 15 , 17 , 26 , 27 , 29 , 32 , 33 , 35 , 37 – 42 ]. Furthermore, some studies also identified a negative association between TAS levels and parasite density [ 17 , 33 , 40 ]. Moreover, Aqeel et al .…”

Section: Resultsmentioning

confidence: 99%

Total antioxidant status levels in malaria: a systematic review and meta-analysis

Kotepui,

Mahittikorn,

Mala

et al. 2024

Malar J

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Background Malaria, a severe health threat, significantly affects total antioxidant status (TAS) levels, leading to considerable oxidative stress. This systematic review and meta-analysis aimed to delineate differences in TAS levels between malaria patients and healthy controls, and assess correlations between disease severity and parasite density. Methods The systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42023448761. A comprehensive literature search was conducted in databases such as Embase, MEDLINE, Journals@Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify studies reporting data on TAS levels in malaria patients. Data from the included studies were analysed both qualitatively and quantitatively. Differences in TAS levels between malaria patients and controls were pooled using a random effects model, with Hedges' g as the effect size measure. Results Of 1796 identified records, 20 studies met the inclusion criteria. The qualitative synthesis of these studies revealed a marked decrease in TAS levels in patients with malaria compared to non-malaria cases. The meta-analysis results showed a significant decrease in TAS levels in patients with malaria compared to non-malaria cases (P < 0.01, Hedges’ g: − 2.75, 95% CI − 3.72 to −1.78, I2: 98.16%, 13 studies), suggesting elevated oxidative stress in these patients. Subgroup analyses revealed that TAS level variations were significantly influenced by geographical region, age group, Plasmodium species, and method for measuring TAS. Notably, TAS levels were significantly lower in severe malaria cases and those with high parasite density, indicating a potential relationship between oxidative stress and disease severity. Conclusion This study highlights the potential utility of TAS as a biomarker for disease risk and severity in malaria. The significant decrease in TAS levels in malaria patients compared to controls implies increased oxidative stress. Further well-designed, large-scale studies are warranted to validate these findings and elucidate the intricate mechanisms linking TAS and malaria.

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Biomarkers of disease severity in vivax malaria

et al. 2021

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Determination of malondialdehyde, Uric Acid, Bilirubin And Total Antioxidant Status, in Children Under 5 Years Suffering From Malaria in Osogbo, Nigeria

Cited by 4 publications

References 23 publications

Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis

Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis

Total antioxidant status levels in malaria: a systematic review and meta-analysis

Biomarkers of disease severity in vivax malaria

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