Determination of Maduramicin in Feedingstuffs and Premixtures by Liquid Chromatography: Development, Validation, and Interlaboratory Study

Jong, J. de; Stoisser, B.; Wagner, Karl W.; Tomassen, M.J.H.; Driessen, J.J.M.; Hofman, P. J.; Putzka, H.A.

doi:10.1093/jaoac/87.5.1033

Cited by 19 publications

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“…A complete necropsy was performed, and samples were taken for routine histology and bacteriology. Pellets were examined for the presence of organochlorine and organophosphate pesticides, pyrethroids, mycotoxins and ionophores (maduramicin, narasin, lasalocid, monensin and salinomycin) as described by Hamilton et al, 1981 andDe Jong et al, 2004. Chromatographic analysis for ionophores was carried out on a LC-10AVP Shimadzu High Performance Liquid Chromatograph.…”

Section: Methodsmentioning

confidence: 99%

Short communication: massive mortality in rabbits by maduramicin poisoning

et al. 2010

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A spontaneous outbreak of maduramicin intoxication in domestic rabbits (Oryctolagus cuniculus) is reported. It is believed that maduramicin incorporated as a coccidiostat into poultry pellet fed to rabbits was the cause, as up to 2.01 ppm was found in the samples and cardiopulmonary clinical signs in most of the rabbits was the common pattern. Findings here were consistent with the classic indications observed in ionophore toxicosis in different species, but little is known about the toxicity of maduramicin in rabbits.

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Section: Methodsmentioning

confidence: 99%

Short communication: massive mortality in rabbits by maduramicin poisoning

et al. 2010

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“…Both methods have the advantages of high analytic sensitiveness and accurate detection results. However, MD has no fluorophore or UV absorption, so it requires derivatization before detection in the high-performance liquid chromatography assays (Jong et al, 2004). The process of sample preparation is also complicated, and requires purification with solid-phase extraction (SPE).…”

Section: Introductionmentioning

confidence: 99%

Development of an immunochromatographic strip for the rapid detection of maduramicin in chicken and egg samples

Guo

Song

et al. 2017

Food and Agricultural Immunology

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Following the steps of antigen synthesis, immunization, cell fusion, ascites preparation and purification, a maduramicin (MD) monoclonal antibody (mAb) was produced. This MD-mAb demonstrated a 50% inhibition concentration value of 3.75 ng/ml, an affinity constant of 3.70 × 10 10 l/mol, and the isotype was IgG3. The MD-mAb has no cross-reactivity with other polyether antibiotics. Using this MD-mAb, a gold immunochromatographic assay was developed to detect MD residues in chicken breast and egg samples. For semi-quantitative detection by the naked eye, the visual limit of detection was 5 ng/g in chicken breast, 10 ng/g in egg. Quantitative results can be obtained by a hand-held strip scan reader, with the detection range of 5.11-19.34 ng/g in chicken breast and 6.46-27.87 ng/g in egg. The strip test took 10 min to run in total. This strip assay is suitable for on-site detection of MD residues in chicken breast and egg samples. ARTICLE HISTORY

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“…Kostadinović, Univerzitet u Novom Sadu, Institut za prehrambene tehnologije, Bulevar cara Lazara 1, 21000 Novi Sad, Novi Sad, Srbija. E-pošta: ljiljana.kostadinovic@fins.uns.ac.rs Rad primljen: 13. maj, 2013 Rad prihvaćen: 5. septembar, 2013 njuje tečna hromatografija sa fluorescentnom [3,4] ili UV detekcijom [5][6][7][8][9]. Ove metode uključuju predkolonsku ili postkolonsku derivatizaciju ili ekstrakciju kolonskom hromatografijom, a obezbeđuju donju granicu detekcije od oko 1mg/kg, osim u slučaju lasalocida i narasina (0,5 mg/kg).…”

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Determination of ionophore coccidiostat salinomycine in premixes and poultry feeding stuffs by liquid chromatography after post-column derivatisation

Kostadinović¹,

Kormanjos²,

Ruzicic

et al. 2014

Hem Ind

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Izvod U radu je razvijen i validiran postupak tečno-hromatografskog određivanja jonofornog kokcidiostatika salinomicina uz UV spektrofotometrijsku detekciju i post-kolonsku derivatizaciju dimetilaminobenzaldehidom (DMAB). Metoda je zasnovana na ekstrakciji salinomicina iz uzoraka hrane za životinje smešom acetonitril-voda (80:20, V/V) i prečišćavanju dobijenih ekstrakata na filteru 0.2µm Acrodisc® PSF. Relativna standardna devijacija za preciznost i obnovljivost je bila u opsegu od 2.4 do 8.8%, odnosno od 2.6 do 8.8%, a obnovljivost je bila u opsegu od 89 do 98%. Donja granica detekcije je iznosila 47 µg/kg, a donja granica kvantifikacije 71 µg/kg. Na osnovu dobijenih rezultata, zaključuje se da je opisana metoda tačna, precizna, selektivna i reproduktivna i da se može primeniti za određivanje salinomicina u premiksima i hrani za živinu.

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Determination of Maduramicin in Feedingstuffs and Premixtures by Liquid Chromatography: Development, Validation, and Interlaboratory Study

Abstract: A reversed-phase liquid chromatography method for determination of maduramicin in feedingstuffs and premixtures was developed, validated, and interlaboratory studied. The extraction solvent was methanol. Maduramicin was detected at 520 nm after postcolumn derivatization with vanillin.

Cited by 19 publications

References 0 publications

Short communication: massive mortality in rabbits by maduramicin poisoning

Short communication: massive mortality in rabbits by maduramicin poisoning

Development of an immunochromatographic strip for the rapid detection of maduramicin in chicken and egg samples

Determination of ionophore coccidiostat salinomycine in premixes and poultry feeding stuffs by liquid chromatography after post-column derivatisation

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