Determination of macro and trace element in multivitamins preparations by inductively coupled plasma optical emission spectrometry with slurry sample introduction

Krejčová, Anna; Kahoun, David; Černohorský, Tomáš; Pouzar, Miloslav

doi:10.1016/j.foodchem.2005.06.022

Cited by 34 publications

(19 citation statements)

References 16 publications

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“…Jarvis recommended a total suspended and dissolved solid content of < 2000 μg mL −1 [15]. Krejcowa et al estimated that at above 1.5% sample inhomogeneity becomes detrimental to precision and accuracy [16]. The slurry particles must be < 20 μm to guarantee efficient nebulization and atomization-excitation in the plasma [17].…”

Section: Introductionmentioning

confidence: 99%

“…Slurry stability is crucial for efficient and reproducible nebulization [18], so stabilizers (e.g. Triton X-100, glycerol) are sometimes added [4,16,19]. Precision is highly dependent on sample homogeneity and analyte partitioning between the solid and liquid phases [6].…”

Section: Introductionmentioning

confidence: 99%

“…Precision is highly dependent on sample homogeneity and analyte partitioning between the solid and liquid phases [6]. Hydrochloric acid [4,14,16,19] and various nitric acid concentrations [16,20] have been used. Good extraction of the analyte is achieved with ultrasonic agitation in nitric acid, ensuring better representativeness of the slurry [21].…”

Section: Introductionmentioning

confidence: 99%

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ICP slurry introduction for simple and rapid determination of Pb, Mg and Ca in plant roots

2007

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Pb, Mg and Ca were simultaneously determined in plant roots by slurry introduction into inductively coupled plasma optical emission spectrometry (SS-ICP-OES). Slurries were prepared in 0.5% or 5% (v/v) HNO 3 with 0.5, or 5% (v/v) Triton X-100. Omission of the Triton X-100 improved results. Compared with wet ashing of the root sample followed by ICP-OES, ICP-MS and FAAS, the method offers: comparable results, simplification of sample preparation, less sample contamination, and reduction in the use of dangerous and corrosive reagents. The precisions varied: 1.7% for Mg, 2.8% for Ca and 4.3% for Pb, and were not significantly different (95% confidence level) from those of conventional analysis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ICP slurry introduction for simple and rapid determination of Pb, Mg and Ca in plant roots

2007

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“…14,15 In the literature, there is a crescent number of studies describing the drug determination and pharmaceutical formulations by several analytical methods, however mineral determination in multivitamins preparations is scarce. [16][17][18][19][20][21] This study aims to propose a method for determination of macro and trace elements in multimineral and multivitamin preparations across dissolution profiles using ICP OES. …”

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confidence: 99%

In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES)

Júnior¹,

Sá²,

Silva³

et al. 2017

J. Braz. Chem. Soc.

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In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis in five multimineral preparations from a dissolution test, in accordance with the United States Pharmacopeia (USP 34 method): apparatus 1, 75 rpm and 900 mL of 0.1 mol L -1 HCl. Element releases in all samples (minimum-maximum in %) were: Ca (14.5-28.2), Cr (54.5-68.0), Cu (2.9-10.0), Fe (4.0-34.3), Mg (6.0-25.2), Mn (2.6-51.2), V (0.0-51.4) and Zn (1.5-107.3). The concentrations of Al, Ba, Cd, Co, Mo, Pb and Se were below the limit of detection of ICP OES. Accuracy was assessed by microwave digestion and recovery values of 94-102%. USP 34 method indicates that not less than 75% of the elements described on the product label must be dissolved in 1 h. Only the release of Zn met the recommendations. The results indicated the need for greater quality control in multivitamin preparations. The dissolution test was validated in order to contribute to Brazilian and other pharmacopoeias. Keywords: multimineral, multivitamin preparations, dissolution profiles, ICP OES IntroductionThe concern about medicine quality has been growing and led the pharmaceutical industry to research, develop and control medicine production, across reliable and effective analytical methods in order to guarantee the quality control of these products. Dissolution tests evaluate the quality of a drug product; obtain the dissolution profile of a drug from a dosage form; identify formulations that present a potential hazard to drug bioavailability and serve as a useful tool in the development of formulations.1,2 Dissolution tests predict in vitro bioequivalence (BE) of a drug. The obtention and comparison of dissolution profiles are important tools for establishing the similarity of pharmaceutical forms containing the active principle of interest. [3][4][5][6] Mineral absorption by living organisms is a dynamic and complex process, dependent on several factors, including levels of ingested element, age, gastrointestinal pH, environmental conditions, nutritional status, element disabled or not, the presence of antagonistic minerals or other nutrients. 7 The consumption of food supplements containing vitamins and minerals has increased considerably in recent decades. Dietary supplements or nutritional products contain vitamins, minerals, herbal products, tissue extracts, proteins and amino acids and other products, and are consumed with the goal of improving health, physical performance and prevent diseases. 8,9 Multivitamin and multimineral preparations in solid pharmaceutical forms (tablets, caplets and capsules) contain the following nutrients: vitamin A, complex-B, C, D, E, K and minerals such as magnesium, zinc, calcium, iodine, selenium, copper, manganese, chromium, molybdenum and others. 10,11 Depending on the chemical form and production conditions, different products may release these substances erratically, affecting absorption. Therefore, in vitro monitoring of the release of these minerals into In vitro Monitoring of Macro...

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“…26 Due to its advantages, ICP OES has become one of the most used techniques for elemental determination, and many studies have been conducted to validate this method for metal analysis in biological samples. 13,[27][28][29][30] Thus, the aim of this study was to compare three different digestion procedures of medicinal plants prior to their multielement analysis by ICP OES. Dry ashing (DA) and two wet digestion procedures, conventional (CD) and assisted by microwave radiation (MW), were evaluated for macro (Ca and Mg) and microelements (Al, Ba, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Se, V and Zn), besides the determination by axial view ICP OES, in medicinal plants and phytomedicines: Maytenus ilicifolia Mart.…”

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confidence: 99%

Multielement Determination of Macro and Micro Contents in Medicinal Plants and Phytomedicines from Brazil by ICP OES

Júnior¹,

Matos²,

Andrade³

et al. 2016

Journal of the Brazilian Chemical Society

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In this study, the elemental composition of nine medicinal plants and phytomedicines was evaluated by using axial view inductively coupled plasma optical emission spectrometry (ICP OES) after three digestion procedures: dry ashing (DA) and two wet digestions with a mineral acid (HNO 3 /H 2 O 2 ) mixture on a conventional hot plate (CD), besides microwave digestion (MW). Accuracy was assessed from spinach leaves (CRM 1570a) and recovery values were in the range of 82 to 113.8%. Precisions, such as relative standard deviation (RSD), below 10% were reached. The MW procedure was preferred for its accuracy (recovery values of 94 to 102%), reduced contamination, increase in the efficiency of the decomposition process, lower residual acidity and reduced time required for digestion. The concentrations of analytes in the samples (minimummaximum in μg g ). The levels of Al, Ba, Cd, Cr, Mo, Pb, Se and V in all investigated samples were found to be below the limit of detection of ICP OES. The multielement analysis by ICP OES showed that the method is simple, fast and reliable for the multielement determination in medicinal plants and phytomedicines.

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Determination of macro and trace element in multivitamins preparations by inductively coupled plasma optical emission spectrometry with slurry sample introduction

Cited by 34 publications

References 16 publications

ICP slurry introduction for simple and rapid determination of Pb, Mg and Ca in plant roots

ICP slurry introduction for simple and rapid determination of Pb, Mg and Ca in plant roots

In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES)

Multielement Determination of Macro and Micro Contents in Medicinal Plants and Phytomedicines from Brazil by ICP OES

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