Multielement Determination of Macro and Micro Contents in Medicinal Plants and Phytomedicines from Brazil by ICP OES

Abstract

In this study, the elemental composition of nine medicinal plants and phytomedicines was evaluated by using axial view inductively coupled plasma optical emission spectrometry (ICP OES) after three digestion procedures: dry ashing (DA) and two wet digestions with a mineral acid (HNO 3 /H 2 O 2 ) mixture on a conventional hot plate (CD), besides microwave digestion (MW). Accuracy was assessed from spinach leaves (CRM 1570a) and recovery values were in the range of 82 to 113.8%. Precisions, such as relative standard deviation (RSD), below 10% were reached. The MW procedure was preferred for its accuracy (recovery values of 94 to 102%), reduced contamination, increase in the efficiency of the decomposition process, lower residual acidity and reduced time required for digestion. The concentrations of analytes in the samples (minimummaximum in μg g ). The levels of Al, Ba, Cd, Cr, Mo, Pb, Se and V in all investigated samples were found to be below the limit of detection of ICP OES. The multielement analysis by ICP OES showed that the method is simple, fast and reliable for the multielement determination in medicinal plants and phytomedicines.

Trace Elements in Leaf Extracts of Eucalyptus grandis Traditionally Used to Treat Common Cold and Flu

“…For the determination of total PTE concentrations (mg/kg), sub-samples (9.56 g) were oven dried (90°C; 12 hours). A dried sample (0.500 g) was digested in 65% nitric acid and 30% hydrogen peroxide (5:1; vol/vol) at 150°C over a hot plate in a fume hood 15. Deionized water (10 ml) was added to the cooled digests which were filtered (Whatman No.…”

The Health Risk Assessment of Essential Elemental Impurities (Cu, Mn and Zn) Through the Dermal Exposure of Herbal Ointment Extracted from Marjoram Herb (Majoranae herbae extractum)

“…The advantages of our research are the (1) practical methodology and (2) relevance of the (1) CPDE = Parenteral PDE × CMF obtained results from regulatory toxicology point of view (ICH Q3D elemental impurities guideline for pharmaceutical industry). The disadvantage is the applied technique (FAAS) which is slower and more demanding in comparison to ICP-MS. Based on the review of scientific literature, it would be important to carry out a broader toxicological risk assessment including other important metallic impurities and different herbal medicinal products [6,[15][16][17][18][19][20].…”

Pollutants harmful to health in herbal products detected by X-ray fluorescence spectroscopy

“…The use of medicinal plants for treatment, cure, and prevention of diseases is one of the oldest forms of human practice (SANTOS et al, 2017). The common misconception that botanical products are harmless and devoid of adverse effects often lead to misuse and unrestricted ingestion, resulting in an increased incidence of side effects and drug interactions (ABDEL-TAWAB, 2018).…”

“…Phytomedications are classified as nutritional supplements based on medicinal herbs and are an important source of nutrients (vitamins, minerals and amino acids) (SANTOS et al, 2017), therefore, scientific studies involving medicinal plants are justified in order to verify their chemical composition and to evaluate their medicinal properties (EKINCI et al, 2004).…”

“…Therefore, the concentration of some chemical elements is one of the criteria that make natural plants admissible for human consumption (MARGUÍ;QUERALT;HIDALGO, 2009). The metals levels are important in herbal medicines due to their toxicological properties as well as from a nutritional point of view (SANTOS et al, 2017). This scenario has contributed to the search for analytical tools to determine the chemical elemental composition of herbal products.…”