Determination of lithium at ultratrace levels in biological fluids by flame atomic emission spectrometry. Use of first-derivative spectrometry

Dol, Isabel; Knochen, Moisés; Vieras, Estela

doi:10.1039/an9921701373

Cited by 22 publications

(12 citation statements)

References 7 publications

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“…Concentrations were adjusted according to a specific gravity of 1.024. boron, lithium and strontium using GM and CI and compared these to reported values. The reported urinary boron (10, 77-79), lithium (11, 78,80) and strontium (12, 81-83) concentrations are summarized in Table 1. These results suggest that urinary boron concentration is on the order of several hundred μg/l with a mean value of approximately 1000 μg/l, that urinary lithium concentration is on the order of μg/l with a mean value of approximately 20 μg/l, and that urinary strontium concentration is on the order of 10-100 μg/l with a mean value of approximately 150 μg/l.…”

Section: Urinary Concentrations Of Boron Lithium and Strontiummentioning

confidence: 99%

An overview of boron, lithium, and strontium in human health and profiles of these elements in urine of Japanese

Usuda

Kono

Dote

et al. 2007

Environ Health Prev Med

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The biological, medical and environmental roles of trace elements have attracted considerable attention over the years. In spite of their relevance in nutritional, occupational and toxicological aspects, there is still a lack of consistent and reliable measurement techniques and reliable information on reference values. In this review our understandings of the urinary profilings of boron, lithium and strontium are summarized and fundamental results obtained in our laboratory are discussed.Over the past decade we have successfully used inductively coupled plasma emission spectrometry for the determination of reference values for urinary concentrations of boron, lithium and strontium. Taking into account the short biological half-life of these elements and the fact that their major excretion route is via the kidney, urine was considered to be a suitable material for monitoring of exposure to these elements. We confirmed that urinary concentrations of boron, lithium and strontium follow a lognormal distribution. The geometric mean reference values and 95% confidence intervals were 798 μg/l (398-1599 μg/l) for boron, 23.5 μg/l (11.0-50.5 μg/l) for lithium and 143.9 μg/l (40.9-505.8 μg/l) for strontium. There were no discrepancies between our values and those previously reported. Our reference values and confidential intervals can be used as guidelines for the health screening of Japanese individuals to evaluate environmental or occupational exposure to these elements.

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Section: Urinary Concentrations Of Boron Lithium and Strontiummentioning

confidence: 99%

An overview of boron, lithium, and strontium in human health and profiles of these elements in urine of Japanese

Usuda

Kono

Dote

et al. 2007

Environ Health Prev Med

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“…Currently, there are various analytical techniques for lithium analysis including flame-AES [10,11], flame-AAS [12], ICP-AES [3,13], ICP-MS [14,15], spectrofluometry [16,17], flow through optode [18] and potentiometry with ion selective electrodes [19]. ICP spectroscopy is widely used for elemental analysis.…”

Section: Introductionmentioning

confidence: 99%

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Dai¹,

Wigman²,

Zhang³

2015

Journal of Chromatography A

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A sensitive analytical method using mixed mode HPLC separation coupled with charged aerosol detection (CAD) was developed for quantitative analysis of lithium. The method is capable of separating lithium ion from different drug matrices and other ions in a single run thus eliminating the organic matrix and ionic analyte interferences without extensive sample preparation such as derivatization and extraction. The separation space and chromatographic conditions are defined by systematic studies of the retention behaviors of lithium and potential interfering ions and different type of pharmaceutical APIs (active pharmaceutical ingredients) under reversed-phase, HILIC and cation/anion exchange mechanisms. Compared to other current analytical techniques for lithium analysis, the presented method provides a new approach and demonstrates high sensitivity (0.02ng for LOD and 0.08ng for LOQ in both standard and sample solution). The method has been validated for pharmaceutical samples and can be potentially applied to biological, food and environmental samples.

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“…Therefore, it is very important to determine Li accurately in biological samples for clinical and medical research investigations. Several analytical methods have been developed for the determination of Li in biological samples, such as flame atomic emission spectrometry (FAES) [7][8][9] , flame atomic absorption spectrometry (FAAS) 8,10 , graphite furnace atomic absorption spectrometry (GFAAS) 1,[11][12][13][14][15][16][17][18] , inductively coupled plasma atomic emission spectrometry (ICP-AES) [19][20][21] , inductively coupled plasma mass spectrometry (ICP-MS) 13,22 , isotope dilution mass spectrometry (IDMS) 23 , ionselective electrode (ISE) 8 etc.…”

Section: Introductionmentioning

confidence: 99%

Interference of Sodium Chloride in the Determination of Lithium by Atomic Spectrometry

Zhao¹

2014

Asian J. Chem.

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Atomic spectrometry has been shown to be very attractive in the determination of lithium in biological samples because of its accuracy and convenience. However, chlorine and sodium have been reported to have interference in either flame or graphite furnace atomic spectrometry. We have investigated the interferences of sodium chloride in atomic spectrometric determination of lithium for biological samples, by nature, contain rather large amount of sodium chloride. The suppressive effect of chlorine has been found in all three kinds of detection modes (graphite furnace atomic absorption, flame atomic emission and flame atomic absorption). The possible mechanism was due to the formation of thermostable lithium chloride, which reduced the number of free lithium atoms in atomization stage. In flame atomic emission spectrometry, sodium caused a spectral interference and produced an emission signal at wavelength 670.8 nm.

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Determination of lithium at ultratrace levels in biological fluids by flame atomic emission spectrometry. Use of first-derivative spectrometry

Cited by 22 publications

References 7 publications

An overview of boron, lithium, and strontium in human health and profiles of these elements in urine of Japanese

An overview of boron, lithium, and strontium in human health and profiles of these elements in urine of Japanese

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Interference of Sodium Chloride in the Determination of Lithium by Atomic Spectrometry

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