Determination of language dominance with synthetic aperture magnetometry: comparison with the Wada test

Hirata, Masayuki; Kato, Aitaro; Taniguchi, Masaaki; Saitoh, Youichi; Ninomiya, Hirotomo; Ihara, Atsushi; Kishima, Haruhiko; Oshino, Satoru; Baba, Takahito; Yorifuji, Shiro; Yoshimine, Toshiki

doi:10.1016/j.neuroimage.2004.05.009

Cited by 124 publications

(119 citation statements)

References 41 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Pseudo-t images were computed for three different frequency bands (5-15 Hz, 15-25 Hz, and 25-50 Hz). These ranges were selected on the basis of previous observations of spectral power changes during language related tasks [17,27]. The SAM results for each subject were transferred into AFNI (http:// afni.nimh.nih.gov/) and normalized onto a Talaraich template brain [28].…”

Section: Megmentioning

confidence: 99%

“…The development of MEG protocols to study expressive language has been more challenging for a number of reasons, the primary one being the computational limitations of the traditional dipole source localization method [14]. Advances in source localization methods have addressed this issue, and several groups have reported identifying Broca's area in adults [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

Pang

Wang

Malone

et al. 2011

Neuroscience Letters

View full text Add to dashboard Cite

Functional MRI (fMRI) is routinely used to non-invasively localize language areas. Magnetoencephalography (MEG) is being explored as an alternative technique. MEG tasks to localize receptive language are well established although there are no standardized tasks to localize expressive language areas. We developed two expressive language tasks for MEG and validated their localizations against fMRI data. Ten right-handed adolescents (μ=17.5 years) were tested with fMRI and MEG on two tasks: verb generation to pictures and verb generation to words. MEG and fMRI data were normalized and overlaid. The number of overlapping voxels activated in fMRI and MEG were counted for each subject, for each task, at different thresholding levels. For picture verb generation, there was 100% concordance between MEG and fMRI lateralization, and for word verb generation, there was 75% concordance. A count showed 79.6% overlap of voxels activated by both MEG and fMRI for picture verb generation and 50.2% overlap for word verb generation. The percentage overlap decreased with increasingly stringent activation thresholds. Our novel MEG expressive language tasks successfully identified neural regions involved in language production and showed high concordance with fMRI laterality. Percentage overlap of activated voxels was also high when validated against fMRI, but showed task-specific and threshold-related effects. The high concordance and high percentage overlap between fMRI and MEG activations confirm the validity of our new MEG task. Furthermore, the higher concordance from the picture verb generation task suggests that this is a promising task for use in the young clinical population.

show abstract

Section: Megmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

Pang

Wang

Malone

et al. 2011

Neuroscience Letters

View full text Add to dashboard Cite

show abstract

“…These studies have demonstrated a high concordance (approximately 90%) between MEG language lateralization and the IAP (69,(91)(92)(93)(94). Other investigators have used silent verb generation and picture naming tasks with comparable results (95,96). Most studies have used equivalent current dipoles (ECD) to determine language lateralization by modeling the distribution of activity every several milliseconds separately in each hemisphere.…”

Section: Megmentioning

confidence: 99%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

View full text Add to dashboard Cite

Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

show abstract

“…This ERS was more pronounced in the right hemisphere only for L1 (Ihara and Kakigi, 2006). Although it has been found that event-related synchrony is most closely related to the hemodynamic response (Singh, et al, 2002), event-related desynchrony is more often seen in cognitive tasks (Niedermeyer and Lopes da Silva, 2005) and with language tasks (Fried, et al, 1981;Hirata, et al, 2004;Ihara, et al, 2003;Yamamoto, et al, 2006).…”

Section: Introductionmentioning

confidence: 89%

An MEG study of the spatiotemporal dynamics of bilingual verb generation

Pang

MacDonald

2012

Brain Research

View full text Add to dashboard Cite

Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences between L1 and L2 use. We tested bilingual adults in the MEG as they completed a picture verb generation task in L1 and L2. We found the expected progression of activation from occipital to temporal to inferior frontal areas. We also observed the following differences. A sustained insula and early cingulate event-related desynchrony was observed only with L2; the fMRI literature suggests that the former reflects an activation, and the latter an inhibition, sub-process for language selection. L2 processes exhibited a lag and were bilateral compared to L1 processes. Finally, L1 and L2 activated adjacent language control in dorsolateral pre-frontal cortex.

show abstract

Determination of language dominance with synthetic aperture magnetometry: comparison with the Wada test

Cited by 124 publications

References 41 publications

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

The use of neuroimaging to study behavior in patients with epilepsy

An MEG study of the spatiotemporal dynamics of bilingual verb generation

Contact Info

Product

Resources

About