Determination of isoniazid among pharmaceutical samples and the patients’ saliva samples by using potassium ferricyanide as spectroscopic probe reagent

A novel molecularly imprinted electrochemiluminescence sensor for isoniazid detection

“…[29][30][31][32][33] Poisoning incidents, even death, have occurred occasionally due to overdose of isoniazid (isonicotinic acid hydrazide, INH), which is a wonder drug for tuberculosis and is one of the top pharmaceuticals that has changed the world. [34][35][36][37][38] Therefore, controlling the dose of INH is very important to sufferers in clinical chemistry, which has prompted study of analytical methods for INH, including titrimetric, 39,40 colorimetric, [41][42][43] spectrophotometric, [44][45][46][47][48][49][50] atomic absorption spectrometric, 51 fluorimetric, [52][53][54] high performance liquid chromatographic, [55][56][57][58][59][60][61][62] capillary electrophoresis, 63,64 chromatographic, 65,66 mass spectrometric, 67 chemiluminescence, [68][69][70][71][72][73][74][75][76][77]…”

The formation of an antitubercular complex [Fe(CN)5(INH)]3− through mercury(II)‐catalyzed ligand substitution reaction: A kinetic and mechanistic study

“…The kinetic, thermodynamic, and volume of activation data from numerous mechanistic studies are consistent with a dissociative mechanism for ligand substitution reactions in these complexes [7,8]. Because of their high stabilities in dark [9], the hexacyanoferrate(II/III) is considered nontoxic [10], but undergo photolysis in acidic medium [11] when exposed to ultraviolet (UV) radiation, producing [Fe(CN) 5 The INH, an antitubercular drug, was first reported to be effective in the treatment of tuberculosis [12,13] but strains of Mycobacterium tuberculosis, a causative agent of disease resistant to INH, were also reported shortly after its introduction [14]. The mutations in drug target genes were held responsible for INH resistance [15][16][17].…”

“…Because of their high stabilities in dark 9, the hexacyanoferrate(II/III) is considered nontoxic 10, but undergo photolysis in acidic medium 11 when exposed to ultraviolet (UV) radiation, producing [Fe(CN) 5 H 2 O] 3− and CN − or HCN. The primary slow reversible thermal aquation of [Fe(CN) 6 ] 4− produces [Fe(CN) 5 H 2 O] 3− , which reacts with pyridine‐4‐carboxylic acid hydrazide or isonicotinic acid, commercially known as isoniazid (INH), yielding substituted antitubercular complex [Fe(CN) 5 (INH)] 3− through the following reactions: The INH, an antitubercular drug, was first reported to be effective in the treatment of tuberculosis 12,13 but strains of Mycobacterium tuberculosis , a causative agent of disease resistant to INH, were also reported shortly after its introduction 14. The mutations in drug target genes were held responsible for INH resistance 15–17.…”

Simultaneous analysis of isoniazid and rifampicin by high-performance liquid chromatography with gradient elution and wall-jet/thin-layer electrochemical detection

“…2 Obviously, the simultaneous determination of INH and RIF is of realistic meaning. The analytical methods reported for the individual determination of INH or RIF in pharmaceutical formulations and biological samples include high-performance liquid chromatography (HPLC), 3,4 ultraviolet-visible (UV-Vis) spectrophotometry, 5,6 chemiluminescence, 7,8 electrochemiluminescence, 9,10 and electrochemical methods. [11][12][13] The simultaneous determination of INH and RIF in pharmaceutical mixtures and biological uids has also been reported, and the analytical methods include HPLC with chemiluminescence detection, 14 diode array detection, 15 UV-Vis detection, 16,17 or mass spectrometry (MS) detection, 18 as well as electrochemical methods such as square-wave voltammetry at a carbon paste electrode 19 and differential pulse voltammetry.…”