Determination of isoflavone (genistein and daidzein) concentration of soybean seed as affected by environment and management inputs

Laurenz, Randy; Tumbalam, Pavani; Naeve, Seth L.; Thelen, Kurt D.

doi:10.1002/jsfa.8184

Cited by 13 publications

(6 citation statements)

References 21 publications

(26 reference statements)

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“…Daidzein belongs to the family of isoflavones, and is abundant in soybeans and soy-based products; and therefore, may be easily obtained from daily dietary intake (32)(33)(34). Known as a type of phytoestrogen, daidzein has been reported to serve an estrogen-like function in hormone-dependent cells, including prostate cells, breast cells, and Sertoli and Leydig cells of the testes (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Zheng

Sun

et al. 2018

Mol Med Report

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Choriocarcinoma is a malignant gestational trophoblastic disease and relapse or drug resistance occurs in ~25% of gestational trophoblastic tumors. Cell apoptosis serves a role in the progression from hydatidiform mole to persistent gestational trophoblastic disease. It has been demonstrated that daidzein [7‑hydroxy‑3‑(4‑hydroxyphenyl)‑4H‑chromen‑4‑one] may induce apoptosis in a number of cancer types via the mitochondrial apoptotic pathway by altering the B‑cell lymphoma (Bcl)‑2/Bcl‑2 associated X, apoptosis regulator (Bax) ratio, and activating the caspase cascade. Daidzein also serves a role in regulation of production of human chorionic gonadotropin in trophoblast cells and inhibition of cell proliferation. However, few reports have been published regarding the effect of daidzein on apoptosis in choriocarcinoma. Therefore, in the present study, JAR and JEG‑3 human gestational choriocarcinoma cells were used to investigate the effect of daidzein on apoptosis of choriocarcinoma cells. Treatment with daidzein for 48 h reduced cell viability in a dose‑dependent manner. The percentages of early and late apoptotic cells also increased following treatment with daidzein in a dose‑dependent manner, with the number of late apoptotic cells increasing more prominently. Furthermore, treatment with daidzein led to apoptosis‑associated alterations in nuclear morphology of JAR and JEG-3 cells. Expression levels of cleaved poly(ADP‑ribose) polymerase, cleaved caspase‑3 and cleaved caspase‑9 increased following treatment with daidzein, whereas the Bcl‑2/Bax ratio decreased in a dose‑dependent manner. In conclusion, the results of the present study demonstrate that daidzein may induce apoptosis of choriocarcinoma cells in a dose‑dependent manner via the mitochondrial apoptotic pathway.

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Section: Discussionmentioning

confidence: 99%

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Zheng

Sun

et al. 2018

Mol Med Report

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“…Daidzein (Daid) is a soy isoflavone compound that has been found in soybeans, grape skins, and grape seeds. 15 Various effects of Daid have been reported in pathophysiological studies, such as enhancing the antioxidant enzyme system and regulating cellular inflammation and apoptosis. [16][17][18] It has been reported that Daid could reduce myocardial injury in diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats

Liu

et al. 2023

Food Funct.

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“…Due to the ability to widen the coronary vessels, lower blood pressure, inhibit α-glucosidase activity and prevent arrhythmia, DA is used for the treatment of cardiovascular diseases, diabetes and menopause symptom amelioration [4][5][6][7][8][9]. DA occurs in varieties of leguminous plants (e. g., soybeans), which are members of the bean family, and is therefore present in all soy products such as milk or tofu, which makes DA an ingredient widely used in diets [10][11][12][13][14]. Due to its important role in human life and extensive range of properties, it is understandable and necessary to discover novel methods of DA detection and determination as well as to develop and improve the currently used methods.…”

Section: Introductionmentioning

confidence: 99%

A Nanocomposite Containing Carbon Nano‐onions and Polyaniline Nanotubes as a Novel Electrode Material for Electrochemical Sensing of Daidzein

et al. 2021

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Glassy carbon electrode (GCE) were modified with nanocomposites containing conductive polyaniline nanotubes (PANInt) and carbon nano‐onions (CNOs). Herein we report a simple and sensitive way for daidzein (DA) determination at concentrations between 1 and 10 μM by linear sweep voltammetry using GCE/PANInt/CNOs system. The DA electrochemical behavior was examined in two buffer environments (pH 7.5 and 4.5) using electrodes modified with the oxidized CNOs or their derivatives containing carboxyl and benzylamino functional groups. The direct electrooxidation of DA was observed at +0.65 V and +0.8 V at pH 7.5 and at +0.7 V and +1.1 V vs. Ag/AgCl at pH 4.5.

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Determination of isoflavone (genistein and daidzein) concentration of soybean seed as affected by environment and management inputs

Abstract: The research supports findings that soybean seed isoflavone levels exhibit a location specific response, and the temporal variability experienced between years appears to influence changes in soybean isoflavone levels more than location. © 2016 Society of Chemical Industry.

Cited by 13 publications

References 21 publications

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats

A Nanocomposite Containing Carbon Nano‐onions and Polyaniline Nanotubes as a Novel Electrode Material for Electrochemical Sensing of Daidzein

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