Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats

Wu, Jinxia; Li, Ke‐Xue; Liu, Yan; Feng, Ailu; Liu, Chunyang; Adu-Amankwaah, Joseph; Ji, Miao‐Jin; Ma, Yue; Hao, Yue; Bu, Huimin; Sun, Hong

doi:10.1039/d2fo03416f

Cited by 14 publications

(11 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Doxorubicin (Dox) is commonly employed in the treatment of malignant tumors; however, its clinical use is significantly limited due to the occurrence of acute, sub-acute, or chronic side effects (Rivankar, 2014). Notably, Dox exhibits a high affinity for cardiomyocytes, thereby leading to cardiotoxicity (Wu et al, 2023). The availability of medications for the treatment or prevention of cardiotoxicity is limited.…”

Section: Discussionmentioning

confidence: 99%

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota

Zhao,

Jiang,

Fan

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Apocynum venetum leaf is commonly utilized for its beneficial effects in reducing blood pressure, inducing sedation, promoting diuresis, anti-aging, and cardioprotection, which also exhibit positive effects on the gut microbiota. The gut microbiota plays a role as an endocrine organ by producing bioactive metabolites that can directly or indirectly impact host physiology, specifically cardiovascular diseases. In this study, main chemical components of A. venetum leaf extract (AVLE) were identified by LC-MS, and an orally administered AVLE was employed to treat mice with doxorubicin (Dox)-induced cardiotoxicity. The results showed that AVLE contained hyperoside and oganic acids. The pharmacological findings revealed that AVLE regulated the gut microbiota, resulting in a significant increase in the levels of two organic acids, indole-3-propionic acid (IPA) and acetic acid (AA). Both IPA and AA exhibited the ability to reduce BNP, CK, and LDH levels in mice with Dox-induced cardiotoxicity. Moreover, IPA demonstrated an improvement in Dox-induced cardiac injury by inhibiting apoptosis, while AA promoted increased secretion of ghrelin through the parasympathetic nervous system, subsequently reducing cardiac fibrosis by decreasing collagen I, collagen III, and activin A. Hence, our study demonstrates that AVLE exerts a beneficial cardioprotective effect by modulating the gut microbiota, providing a potential novel target for the treatment and prevention of Dox-induced cardiotoxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota

Zhao,

Jiang,

Fan

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…However, excessive autophagy could lead to non-apoptotic cell death. 63 Previous studies have demonstrated that autophagy is highly associated with MPTP-induced parkinsonism in zebrafish models. 28,29 On the one hand, autophagy activation can reduce oxidative stress and prevent neuronal degeneration, and on the other hand, excessive autophagy can promote apoptosis and lead to the occurrence of PD.…”

Section: Papermentioning

confidence: 99%

The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish

Xu,

Qiu,

Zhang

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Daidzein is a soy isoflavone that has shown protective effects against doxorubicin-induced cardiac injury in rats, as pretreatment with a low quantity significantly improved cardiac function and relieved histopathological deterioration of cardiomyocytes alleviated by doxorubicin. It decreased the protein expression of LC3 II, Bax, p-Akt, and cleaved caspase3, while enhancing cyclin D1 and Bcl-2, decreased apoptosis and autophagy by downregulating the PI3K/Akt pathway, thus defending the hearts from doxorubicin-induced cardiac damage [ 111 ].…”

Section: Autophagymentioning

confidence: 99%

Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review of in-vivo and in-vitro studies

Khater,

Shalabi,

Alammash

et al. 2023

J Adv Vet Anim Res

View full text Add to dashboard Cite

Phytoestrogens are non-steroid polyphenolic materials present in 300 plants. Regarding their structural similarities to estradiol, phytoestrogens attach to estrogen receptors and display anti-or pro-estrogenic activities. This review explored phytoestrogens’ potential advantages and autophagy properties in light of their future application for disease management, highlighting how phytoestrogens could modulate autophagy. Research has examined the prospective benefits of phytoestrogens for the anticipation and management of various conditions, including signs of menopause, tumors, skin deterioration, osteoporosis, heart disease, neurodegenerative conditions, disorders of the immune system, and metabolic syndrome, owing to their therapeutic effects. As phytoestrogens can activate or inhibit autophagy, which has antioxidant, apoptotic, anti-mutagenic, anticancer, transcriptional, and genomic impacts on cancer and aging illnesses, phytoestrogens could influence diseases through the modulation of autophagy. The collaborative research on animal models, utilization of genetic techniques, and administration of pharmacolog¬ically active substances has indicated the possible therapeutic benefits of autophagy modulation in various illnesses. Further research is required to illustrate the pathways by which phytoestro¬gens modulate autophagy and the possible therapeutic effects on these diseases.

show abstract

Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats

Abstract: Backgrounds: Doxorubicin (Dox) is a classical antitumor antibiotic widely restricted for use due to its cardiotoxicity. Daidzein (Daid) is a soy isoflavone that enhances antioxidant enzyme systems and inhibits apoptosis...

Cited by 14 publications

References 46 publications

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota

The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish

Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review of in-vivo and in-vitro studies

Contact Info

Product

Resources

About