Determination of histamine in plasma by high-speed liquid chromatography

Tsuruta, Yasuto; Kohashi, Kenichi; Ohkura, Yosuke

doi:10.1016/s0378-4347(00)81209-8

Cited by 75 publications

(22 citation statements)

References 6 publications

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“…In addition, the HPLC system used in the present method could clearly separate spermidine from histamine. Thus, the procedure descrided in this paper has a number of advantages such as simplicity, specificity, and reproducibility , as well as sensitivity over many other methods previously reported (Beaven et al 1972;Siraganian 1974;Tsuruta et al 1978;Endo 1981). …”

Section: Discussionmentioning

confidence: 91%

“…This method needs to use a radioisotope and to purify a histamine-N-methyltransferase enzyme, since it is based upon the conversion of histamine to 14-C methylhistamine by incubation with histamine-N-methyltransferase and S-adenosylmethionine-14C-methyl. Previously, Tsuruta et al (1978) applied HPLC for the measurement of plasma histamine levels after extraction of histamine with butanol and chroloform. When we measured histamine concentration using this method , we found that the extraction procedure gave variable and low recovery of histamine .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The determination of blood histamine in asthmatic patients with a simple and sensitive method.

Izumi

Hoshi

Mue

et al. 1984

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The determination of blood histamine in asthmatic patients with a simple and sensitive method.

Izumi

Hoshi

Mue

et al. 1984

Tohoku J. Exp. Med.

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“…Sample Processing. Histamine was extracted with n-butanol as previously described [11,12], Bulbar con junctival tissue was excised, washed with PBS (pH 7.4) and homogenized in 2 ml ice-cold 0.4 M perchloric acid. After centrifugation (3,000 rpm, 10 min) to 1.5 ml of the supernatant, 1.0 ml 5 A' NaOH and 1.0 ml n-butanol were added.…”

Section: Methodsmentioning

confidence: 99%

Pharmacodynamics of Amlexanox (AA-673) in Normal and Anaphylactic Rat Conjunctiva and Its Effect on Histamine Concentration

Rankov

Sasaki²,

Fukuda³

1990

Ophthalmic Res

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The pharmacodynamics of Amlexanox (AA-673), an azoxanthone derivative recently developed as an ocular anti-allergic drug, were studied in normal and anaphylactic rat conjunctiva. Ocular anaphylaxis was induced by topical application of dithiothreitol and antigen challenge (egg albumin). The drug concentration was measured at 5, 30, 60 and 120 min after instillation of AA-673 0.25% ophthalmic solution. Histamine concentrations in the pretreated and untreated anaphylactic conjunctiva were compared. In both groups the drug concentration decreased exponentially with time, showing a marked delay in the anaphylactic group. There was a significant difference in histamine values between the pretreated and untreated groups.

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“…Histamine was determined fluorimetrically after derivation with ortho-phthalaldehyde (OPA) [15] and separation of the fluo rescent products by high-performance liquid chromatography (HPLC) [16]. Detection limit was 1 ng histamine/ml.…”

Section: Histamine Determinationmentioning

confidence: 99%

Decreased Releasability of Basophils from Patients with Cold Urticaria after Cold Exposure

Hessler¹,

Pufahl²,

Christophers³

1989

Int Arch Allergy Immunol

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Histamine release from peripheral blood basophils challenged with C5a, f-met-peptides and calcium ionophore was studied in patients with cold urticaria before and after exposure to low environmental temperatures. Compared to healthy controls, stimulated mediator release before cold exposure was increased in 7 of 11 patients. When challenged by cold exposure mediator release from in vitro-stimulated basophils was decreased. This decrease was more pronounced after stimulation with receptor-mediated stimuli (e.g. C5a) as compared to receptor-unrelated stimuli, e.g. calcium inophore. In 4 of 11 patients stimulated mediator release before cold exposure was moderately increased. Also after cold exposure only a weak decrease of stimulated histamine release was seen. Levels of activated complement components (C3a) before and after cold exposure failed to provide evidence for complement activation in vivo. Also the number of circulating basophils as well as their cellular histamine content remained normal after cold exposure. The results show that in these patients release of histamine is altered before and after cold exposure. These changes in basophil responsiveness are not due to complement activation in vivo.

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Determination of histamine in plasma by high-speed liquid chromatography

Cited by 75 publications

References 6 publications

The determination of blood histamine in asthmatic patients with a simple and sensitive method.

The determination of blood histamine in asthmatic patients with a simple and sensitive method.

Pharmacodynamics of Amlexanox (AA-673) in Normal and Anaphylactic Rat Conjunctiva and Its Effect on Histamine Concentration

Decreased Releasability of Basophils from Patients with Cold Urticaria after Cold Exposure

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