Determination of ginsenosides by Bacillus polymyxa conversion and evaluation on pharmacological activities of the conversion products

Ji, Qing; Gao, Yugang; Zhao, Yan; He, Zhongmei; Zhang, Pu; He, Yang; Xue, Li; Zhang, Lianxue

doi:10.1016/j.procbio.2015.03.013

Cited by 11 publications

(7 citation statements)

References 26 publications

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“…It is hypothesised that Pp-7250 co-bacterial agent application to increase the abundance of Bacillus, which is responsible for the growth promotion, biological control and pesticides residue degradation effects of ginseng. Paenibacillus not only has good applications in biological control [36,78], but also has good effects on the promotion of ginseng growth and the conversion of ginsenosides and ve pesticides, uazinam, BHC, PBNB, chlorpyrifos and chlorpyrifos, and DDT [34,[94][95][96]]. In the present study, the effects of Paenibacillus on ginseng yield, relative defence e cacy, and the content of the nine ginsenosides and pesticides residue degradation were signi cantly positively correlated.…”

Section: Discussionmentioning

confidence: 82%

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Paenibacillus polymyxa and Bacillus cereus co-bacterial agent promotes ginseng resistance to diseases and improves yield, quality and pesticide degradation through regulating rhizosphere microbial community structure and potential function

Li,

Liu,

Gao

et al. 2024

Preprint

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Background: The ginseng endophyte Paenibacillus polymyxa Pp-7250 (Pp-7250) have multifaceted roles such as preventing ginseng diseases, promoting growth, increasing ginsenoside accumulation and degrading pesticide residues, these effects still room for improvements. Composite fungicide is an effective means to improve the biocontrol effect of fungicide, but the effect of Pp-7250 in combination with its symbiotic bacteria on ginseng needs to be further researched, and its mechanism of action still remains to be elucidated. In order to elucidate the effect of Paenibacillus polymyxa and Bacillus cereus co-bacterial agent on the yield and quality of understory ginseng, as well as to investigate its mechanism of action. Firstly, the effects of Bacillus cereus (BS), Paenibacillus polymyxa Pp-7250(PS) and Paenibacillus polymyxa and Bacillus cereus co-bacterial agent (PB) treatments on ginseng yield, ginsenoside content, disease prevention and pesticide degradation rate were evaluated by field experiments. Secondly, differences in microbial communities in ginseng rhizosphere soils with different treatments were analyzed using high‐throughput amplicon sequencing. Finally, correlation analysis was performed to elucidate the mechanism of action of PB co-bacterial agent in improving the yield and quality of ginseng. Results: The results indicate that PB treatment improved ginseng yield, ginsenoside accumulation, disease prevention and pesticide degradation. The mechanism is that PB treatment increased the abundance of beneficial microorganisms Rhodanobacter, Pseudolabrys, Gemmatimonas, Bacillus, Paenibacillus, Cortinarius, Russula, Paecilomyces, Trechisporaincreased and decreased the abundance of pathogenic microorganisms Ellin6067, Acidibacter, Fusarium, Tetracladium, Alternaria, and Ilyonectria in ginseng rhizosphere soil. PB co-bacterial agent enhanced the function of microbial metabolic pathways, biosynthesis of secondary metabolites, biosynthesis of antibiotics, biosynthesis of amino acids, carbon fixation pathways in prokaryotes, DNA replication, terpenoid backbone biosynthesis, and decreased the function of microbial plant pathogen and animal pathogen. This study provided a theoretical reference for indepth research on improving the yield and quality of ginseng. Conclusion: The combined agent of Paenibacillus polymyxa and Bacillus cereus may be a potential biocontrol agent to promote the resistance of ginseng to disease, improve the yield, quality and pesticide degradation.

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Section: Discussionmentioning

confidence: 82%

“…Bene cial microorganisms have important roles such as biological control, promote plant growth, effective composition accumulation and degrade pesticides residue [9][10][11][12]. The use of Bioinoculants for ecological cultivation of ginseng is of great relevance in providing high-quality and safe ginseng herbs [13,14].…”

Section: Introductionmentioning

confidence: 99%

Paenibacillus polymyxa and Bacillus cereus co-bacterial agent promotes ginseng resistance to diseases and improves yield, quality and pesticide degradation through regulating rhizosphere microbial community structure and potential function

Li,

Liu,

Gao

et al. 2024

Preprint

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“…In addition, the total levels of nine monomeric saponins in 1- to 4-year-old ginseng treated with Bacillus polymyxis spraying and root irrigation were 36.83%, 44.52%, 67.96%, and 79.44% higher than those in the control from the same year. At the same time, coculture of B. polymyxis and ginseng significantly increased the levels of 12 kinds of ginsenoside monomers, especially the levels of the rare ginsenosides CK and protopanaxadiol, which increased by 1.38- and 7.78-fold, respectively [ 80 , 81 ].…”

Section: Molecular Mechanisms Affecting the Secondary Metabolites Of ...mentioning

confidence: 99%

Functional Endophytes Regulating Plant Secondary Metabolism: Current Status, Prospects and Applications

Xiong

Wen

et al. 2023

IJMS

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Endophytes, which are widely found in host plants and have no harmful effects, are a vital biological resource. Plant endophytes promote plant growth and enhance plants’ resistance to diseases, pests, and environmental stresses. In addition, they enhance the synthesis of important secondary metabolites in plants and improve the potential applicability of plants in agriculture, medicine, food, and horticulture. In this review, we summarize the recent progress in understanding the interaction between endophytes and plants and summarize the construction of synthetic microbial communities (SynComs) and metaomics analysis of the interaction between endophytes and plants. The application and development prospects of endophytes in agriculture, medicine, and other industries are also discussed to provide a reference for further study of the interaction between endophytes and plants and further development and utilization of endophytes.

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“…The approaches by way of biotransformation to generate rare ginsenosides are outlined in Table 2. 119–139 The extraction residues 119–121 or ginsenosides mixture 122 are used as the substrates for cultivating different bacteria or fungi to produce the rare ginsenosides. With ginsenoside Rb1 as the substrate, Rd and Rh2 could be produced under the action of Trichoderma longibrachiatum 123 or bacteria.…”

Section: Phytochemistrymentioning

confidence: 99%

Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis

Liu

Zuo

et al. 2022

Nat. Prod. Rep.

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Determination of ginsenosides by Bacillus polymyxa conversion and evaluation on pharmacological activities of the conversion products

Cited by 11 publications

References 26 publications

Paenibacillus polymyxa and Bacillus cereus co-bacterial agent promotes ginseng resistance to diseases and improves yield, quality and pesticide degradation through regulating rhizosphere microbial community structure and potential function

Paenibacillus polymyxa and Bacillus cereus co-bacterial agent promotes ginseng resistance to diseases and improves yield, quality and pesticide degradation through regulating rhizosphere microbial community structure and potential function

Functional Endophytes Regulating Plant Secondary Metabolism: Current Status, Prospects and Applications

Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis

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