Determination of Free Salicylic Acid in Buffered Aspirin Tablets

Determination of Drug Stability in Aspirin Tablet Formulations by High-Pressure Liquid Chromatography

“…Quantitative extraction of aspirin and salicylic acid was not obtained with combinations of methanol and chloroform, probably because of adsorption on tablet excipients (36,37). Successful drug release was achieved by initially wetting the pulverized sample with 98% formic acid, followed by dilution with chloroform (37).…”

“…Keyphrases Hypoglycemics-improved absorption through increased hydrophilicity 0 Tolbutamide-improved absorption through increased hydrophilicity 0 Acetohexamide-improved absorption through increased hydrophilicity Absorption-tolbutamide and acetohexamide, improved absorption through increased hydrophilicity Certain oral hypoglycemics, e.g., acetohexamide and tolbutamide, are poorly water soluble and have irregular dissolution rates (1)(2)(3). Coprecipitation with povidone and solid dispersion of tolbutamide in polyethylene glycols have been utilized to increase the dissolution rate (4,5) and bioavailability (5,6).…”

“…Free salicylic acid has been determined by column chromatography (1)(2)(3) and direct UV spectrophotometry (4,5). Free salicylic acid has been determined by column chromatography (1)(2)(3) and direct UV spectrophotometry (4,5).…”

Quick Specific Assay for Aspirin

“…However, these methods require involved sample preparation as well as sophisticated instrumentation (3,4). However, these methods require involved sample preparation as well as sophisticated instrumentation (3,4).…”

“…Preliminary screening of a large number of potential formulations can be arduous, since most current methods of analysis generally consist of several steps: extractions or column separations followed by UV, colorimetric, or GLC assay (1)(2)(3)(4). Therefore, its stability is often the initial concern in any formulation screening program.…”