Comparison of Methods for the Determination of Aalicylic Acid in Buffered Aspirin Tablets

Determination of Drug Stability in Aspirin Tablet Formulations by High-Pressure Liquid Chromatography

“…Keyphrases Hypoglycemics-improved absorption through increased hydrophilicity 0 Tolbutamide-improved absorption through increased hydrophilicity 0 Acetohexamide-improved absorption through increased hydrophilicity Absorption-tolbutamide and acetohexamide, improved absorption through increased hydrophilicity Certain oral hypoglycemics, e.g., acetohexamide and tolbutamide, are poorly water soluble and have irregular dissolution rates (1)(2)(3). Coprecipitation with povidone and solid dispersion of tolbutamide in polyethylene glycols have been utilized to increase the dissolution rate (4,5) and bioavailability (5,6).…”

“…Free salicylic acid has been determined by column chromatography (1)(2)(3) and direct UV spectrophotometry (4,5). Free salicylic acid has been determined by column chromatography (1)(2)(3) and direct UV spectrophotometry (4,5).…”

Determination of salicylic acid in acetylsalicylic acid by second derivative u. v.-spectrophotometry

“…These methods have employed partition chromatographic (Levine & Weber 1968;Guttman & Salomon 1969), gas liquid chromatography (Galante et al 1981), liquid chromatography (Baum & Cantwell 1978 This paper reports a simple, rapid and accurate method for the direct determination of salicylic acid in ASA by second derivative u.v.-spectrophotometry. The effect of drum rotational speed on material carryover and process efficiency (solids application rate 7.30 g min-1, charge 10 kg).…”

Simultaneous GLC Estimation of Salicylic Acid and Aspirin in Plasma

“…Salicylic acid has been estimated, either in combination with aspirin (17) or individually following a physical separation step (18)(19)(20)(21). By these techniques, either salicylic acid alone or salicylic acid plus aspirin may be determined.…”