Simultaneous GLC Estimation of Salicylic Acid and Aspirin in Plasma

Determination of acetylsalicylic acid and its major metabolite, salicylic acid, in human plasma using liquid chromatography–tandem mass spectrometry: application to pharmacokinetic study of Astrix® in Korean healthy volunteers

“…SA is further metabolized to gentisic acid, salicyluric acid and other conjugates (Mays et al, 1984). A number of methods have been reported for the analysis of ASA and its metabolites in plasma samples, including HPLC (Peng et al, 1978;Buskin et al, 1982;Bakar and Niazi, 1983;Mays et al, 1984;O'Kruk et al, 1984;Shen et al, 1990;Kees et al, 1996;McMahon and Kelly, 1998;Pirola et al, 1998 and references therein), GC (Walter et al, 1974;Rance et al, 1975) and capillary electrophoresis (Hansen et al, 1998). The method using on-line solid-phase extraction (SPE) by a methylcellulose-immobilized-strong anion-exchanger (MC-SAX) in a column-switching HPLC system achieved the highest sensitivity among the assay methods previously reported.…”

Sensitive determination of aspirin and its metabolites in plasma by LC–UV using on-line solid-phase extraction with methylcellulose-immobilized anion-exchange restricted access media

“…SA is further metabolized to gentisic acid (GA), salicyluric acid (SUA), and other conjugates [22]. A number of methods have been reported for the analysis of ASA and its metabolites in plasma samples, including LC [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], GC [39][40][41][42], and capillary electrophoresis [43]. Most of these methods utilized an off-line sample procedure involving solvent extraction and therefore required evaporation and reconstitution steps.…”

Direct Analysis of Salicylic Acid in Keratolytic Plaster by Gas–Solid Chromatography

“…The proposed method is superior to the methyl ester-methyl ether and trimethylsilyl GLC methods because multiple derivatives of I may be formed upon derivatization (11)(12)(13)(14), which may lead to errors. The proposed method is superior to the methyl ester-methyl ether and trimethylsilyl GLC methods because multiple derivatives of I may be formed upon derivatization (11)(12)(13)(14), which may lead to errors.…”